Developmentally regulated and strain-specific expression of murine VH gene families.

Somatic generation of antibody diversity

1983 • 3,275 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines

1982 • 228 citations

VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

1986 • 186 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

Frequencies of mitogen-reactive B cells in the mouse. I. Distribution in different lymphoid organs from different inbred strains of mice at different ages

1977 • 158 citations

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

1985 • 147 citations

Amino acid sequence of a mouse immunoglobulin mu chain.

1979 • 134 citations

One heavy chain variable region gene segment subfamily in the BALBc mouse contains 500–1000 or more members

1986 • 132 citations

Antibody Repertoires of Normal BALB/c Mice: B Lymphocyte Populations Defined by State of Activation

1986 • 129 citations

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

1986 • 127 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.

1975 • 117 citations

Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

1983 • 113 citations

Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

1987 • 100 citations

Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.

1984 • 84 citations

Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.

1987 • 72 citations

Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.

1985 • 72 citations

Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

1981 • 69 citations

Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.

1979 • 64 citations

Characterization of Productive and Sterile Transcripts from the Immunoglobulin Heavy-Chain Locus: Processing of μ_m and μ_s mRNA

1983 • 63 citations

Immunological unresponsiveness to native dextran B512 in young animals of dextran high responder strains is due to lack of Ig receptors expression. Evidence for a nonrandom expression of V-genes.

1978 • 62 citations

Organization of the murine immunoglobulin VH complex in the inbred strains.

1987 • 59 citations

Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies.

1986 • 53 citations

Immunoglobulin V_H region genes of the mouse are organized in overlapping clusters

1987 • 51 citations

Multiple VH gene segments encode murine antistreptococcal antibodies.

1984 • 50 citations

Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes.

1986 • 47 citations

Organization of genes and spacers within the mouse immunoglobulin VH locus.

1981 • 46 citations

Ontogeny of B cell precursors responding to alpha 1- greater than 3 dextran in BALB/c mice.

1984 • 44 citations

Evolution of pseudogenes in the immunoglobulin V H-gene family of the mouse

1987 • 42 citations

High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains.

1987 • 41 citations

Genetic and temporal control of neonatal antibody expression.

1983 • 36 citations

The Ontogeny and Organization of the Lymphoid System

1985 • 36 citations

Late clonal selection and expansion of the TEPC-15 germ-line specificity.

1980 • 34 citations

Selective use of the VHQ52 family in functional VH to DJH rearrangements in a B precursor cell line.

1987 • 23 citations