Programmed Development of the Antibody Repertoire

The structure and evolution of the human β-globin gene family

1980 • 1,398 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Immunoglobulin Genes

1983 • 341 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

The Structure and Evolution of the Human /?-Globin Gene Family

1980 • 301 citations

FETAL RESPONSE TO ANTIGENIC STIMULUS

1963 • 261 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

1985 • 244 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

Immunologic responses to bacteriophage ϕX 174 in immunodeficiency diseases

1971 • 222 citations

Evidence that murine pre-B cells synthesise μ heavy chains but no light chains

1979 • 208 citations

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice

1984 • 184 citations

Regulated progression of a cultured pre-B-cell line to the B-cell stage

1985 • 174 citations

Immunoglobulin Gene Rearrangement in Immature B Cells

1980 • 172 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes

1985 • 152 citations

The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse

1983 • 151 citations

Molecular basis of a mouse strain-specific anti-hapten response

1983 • 150 citations

Nucleotide sequence of the S-1 mitochondrial DNA from the S cytoplasm of maize

1985 • 144 citations

THE DEVELOPMENT OF THE IMMUNE RESPONSE

1964 • 140 citations

Molecular Genetics of the T Cell-Receptor Beta Chain

1985 • 140 citations

Expression of genes of the T-cell antigen receptor complex in precursor thymocytes

1985 • 135 citations

Formation of B Lymphocytes in Fetal and Adult Life

1981 • 135 citations

Murine B cell differentiation lineages.

1984 • 124 citations

Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.

1976 • 123 citations

CBA/N Immune Defective Mice; Evidence for the Failure of a B Cell Subpopulation to be Expressed

1982 • 121 citations

Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region Genes

1984 • 120 citations

The B Cell Specificity Repertoire: Its Relationship to Definable Subpopulations

1975 • 120 citations

ONTOGENY OF B-LYMPHOCYTE FUNCTION

1974 • 100 citations

The genetic control of antibody variable regions in the mouse

1978 • 95 citations

Primary immunodeficiency diseases

1986 • 91 citations

Chance, necessity and antibody gene dynamics

1983 • 87 citations

Expression of phosphorylcholine-specific B cells during murine development

1977 • 85 citations

In Vitro Analysis of Murine B-Cell Development

1985 • 80 citations

Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis.

1985 • 79 citations

Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes.

1981 • 79 citations

The elements of the bithorax complex

1983 • 78 citations

Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

1984 • 77 citations

Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies.

1983 • 74 citations

THE DEVELOPMENT OF THE IMMUNE RESPONSE

1963 • 72 citations

Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.

1985 • 72 citations

Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.

1979 • 64 citations

Early pre-B cells from normal and X-linked agammaglobulinaemia produce Cμ without an attached VH region

1983 • 63 citations

Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family.

1985 • 62 citations

Immunological unresponsiveness to native dextran B512 in young animals of dextran high responder strains is due to lack of Ig receptors expression. Evidence for a nonrandom expression of V-genes.

1978 • 62 citations

The Biology of Idiotypes

1984 • 58 citations

Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism.

1985 • 58 citations

Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny.

1979 • 55 citations

Analysis of the diversity of murine antibodies to dextran B1355. II. Demonstration of multiple idiotypes with variable expression in several strains.

1977 • 53 citations

Multiple VH gene segments encode murine antistreptococcal antibodies.

1984 • 50 citations

Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes.

1986 • 47 citations

The emigration of lymphocytes from Peyer's patches in sheep

1984 • 45 citations

Ontogeny of B cell precursors responding to alpha 1- greater than 3 dextran in BALB/c mice.

1984 • 44 citations

Precocious and enhanced functional maturation of B lineage cells in New Zealand Black mice during embryonic development.

1984 • 41 citations

Lack of neonatal susceptibility to induction of tolerance by polysaccharide antigens

1976 • 41 citations

Epstein-Barr virus-induced lymphoblastoid cell lines derived from the peripheral blood of patients with X-linked agammaglobulinemia can secrete IgM

1984 • 40 citations

Immune response to levan. II. T independence of suppression of cross-reactive idiotypes by anti-idiotype antibodies.

1979 • 39 citations

Restriction in IgM expression—1

1980 • 37 citations

Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice

1977 • 36 citations

Late clonal selection and expansion of the TEPC-15 germ-line specificity.

1980 • 34 citations

Network Regulation of the Immune Response to Bacterial Polysaccharide Antigens

1985 • 28 citations

B cell immune repertoire diversifies in a predictable temporal order in vitro.

1985 • 26 citations

Analysis of the diversity of murine antibodies to dextran B1355. III. Idiotypic and spectrotypic correlations

1978 • 26 citations

Immune Response to Levan

1979 • 24 citations

Development of Humoral Immunity in Lethally Irradiated Mice Reconstituted with Fetal Liver

1974 • 24 citations

Direct evidence for interaction between human erythroid progenitor cells and a hemoglobin switching activity present in fetal sheep serum.

1983 • 22 citations

The Genes Encoding Anti-NP Antibodies in Inbred Strains of Mice

1984 • 21 citations

Epidemiology and treatment of hypogammaglobulinemia.

1983 • 21 citations

Clonotypic analysis of the fetal B cell repertoire: evidence for an early and predominant expression of idiotypes associated with the VH 36-60 family.

1986 • 12 citations

Termites and methane (reply)

1983 • 6 citations