Role of homology-directed recombination: Predominantly productive rearrangements of VH81X in newborns but not in adults

Sequences of proteins of immunological interest

1984 • 3,427 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

1988 • 432 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

1990 • 252 citations

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

1990 • 203 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding.

1992 • 178 citations

Structure and evolution of mammalian V_H families

1990 • 177 citations

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

1992 • 154 citations

B cell development in the bone marrow.

1990 • 148 citations

Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

1992 • 146 citations

Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse.

1979 • 137 citations

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

1986 • 127 citations

VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules.

1984 • 123 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression.

1988 • 104 citations

Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements.

1988 • 103 citations

Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

1987 • 100 citations

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells.

1991 • 95 citations

Conservation of an immunoglobulin variable-region gene family indicates a specific, noncoding function.

1989 • 87 citations

Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus

1992 • 83 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Selection of V_H gene repertoires: differentiating B cells of adult bone marrow mimic fetal development

1990 • 74 citations

Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.

1983 • 74 citations

Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains.

1991 • 71 citations

Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment

1989 • 70 citations

Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells.

1991 • 67 citations

Developmentally controlled selection of antibody genes: Characterization of individual V_H7183 genes and evidence for stage‐specific somatic diversification

1992 • 64 citations

Structural Analyses of Human Developmentally Regulated Vh3 Genes

1990 • 48 citations

Comparison of Junctional Diversity in the Neonatal and Adult Immunoglobulin Repertoires

1992 • 47 citations

Sequence and fine specificity analysis of primary 511 anti-phosphorylcholine antibodies.

1989 • 38 citations