An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Mitochondrial control of cell death

2000 • 3,098 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Apoptosis in the nervous system

2000 • 1,850 citations

Apoptosis in neurodegenerative disorders

2000 • 1,542 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1994 • 1,032 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

From bench to clinic with apoptosis-based therapeutic agents

2000 • 703 citations

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease

2000 • 682 citations

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1999 • 641 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Energetics in the pathogenesis of neurodegenerative diseases

2000 • 479 citations

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1997 • 460 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease

1998 • 426 citations

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1999 • 415 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism

1999 • 304 citations

Neuroprotection by the Inhibition of Apoptosis

2000 • 222 citations

A fluorescent double‐labeling method to detect and confirm apoptotic nuclei in parkinson's disease

1998 • 198 citations

Role of mitochondria in the etiology and pathogenesis of Parkinson's disease

1995 • 172 citations

Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA

1980 • 155 citations

On the question of apoptosis in the parkinsonian substantia nigra

1997 • 145 citations

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat

1994 • 137 citations

A New Strategy for Large-Scale Preparation of High-Titer Recombinant Adeno-Associated Virus Vectors by Using Packaging Cell Lines and Sulfonated Cellulose Column Chromatography

1996 • 133 citations

Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease

1999 • 114 citations

Transgenic mice expressing a dominant negative mutant interleukin-1β converting enzyme show resistance to MPTP neurotoxicity

1999 • 82 citations

Parkinson disease gene therapy moves toward the clinic

2000 • 48 citations