Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

1999 • 1,290 citations

Alzheimer's Disease and Parkinson's Disease

2003 • 1,277 citations

Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein

2002 • 1,193 citations

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

2002 • 1,152 citations

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

2001 • 1,116 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

2001 • 1,036 citations

Current Protocols in Human Genetics

2001 • 1,023 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

2001 • 738 citations

Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

2002 • 722 citations

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors

1998 • 691 citations

Understanding cell death in parkinson's disease

1998 • 678 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

2001 • 675 citations

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

2002 • 642 citations

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

2002 • 577 citations

Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

2001 • 570 citations

Altered Proteasomal Function in Sporadic Parkinson's Disease

2002 • 565 citations

A Wide Variety of Mutations in the Parkin Gene Are Responsible for Autosomal Recessive Parkinsonism in Europe

1999 • 526 citations

The septins: roles in cytokinesis and other processes

1996 • 502 citations

Neuropathology in mice expressing human alpha-synuclein.

2000 • 499 citations

Mutations in NR4A2 associated with familial Parkinson disease

2002 • 478 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein Is Sensitive to Parkinson's Disease-Linked Mutations and Occurs by a Pore-like Mechanism

2002 • 470 citations

Neuropathology in Mice Expressing Human α-Synuclein

2000 • 456 citations

The septin CDCrel-1 binds syntaxin and inhibits exocytosis

1999 • 371 citations

Subunit Composition, Protein Interactions, and Structures of the Mammalian Brain sec6/8 Complex and Septin Filaments

1998 • 356 citations

Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.

2003 • 282 citations

Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

2001 • 279 citations

Septins: cytoskeletal polymers or signalling GTPases?

1999 • 272 citations

Parkin Binds to α/β Tubulin and Increases their Ubiquitination and Degradation

2003 • 247 citations

Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

2001 • 238 citations

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

2001 • 221 citations

Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases

2001 • 213 citations

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

2003 • 212 citations

Synaptic Vesicle Transporter Expression Regulates Vesicle Phenotype and Quantal Size

2000 • 210 citations

Borg proteins control septin organization and are negatively regulated by Cdc42

2001 • 208 citations

Novel roles for mammalian septins: from vesicle trafficking to oncogenesis

2001 • 208 citations

Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease

2003 • 204 citations

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

2003 • 183 citations

Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain

2000 • 180 citations

Parkin and the Molecular Pathways of Parkinson's Disease

2001 • 160 citations

A prototypic platelet septin and its participation in secretion

2002 • 129 citations

Differential localization of septins in the mouse brain

2000 • 112 citations

Parkin

2003 • 112 citations

Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond

1999 • 110 citations

Recombinant AAV vectors containing the foot and mouth disease virus 2A sequence confer efficient bicistronic gene expression in cultured cells and rat substantia nigra neurons

2001 • 99 citations

Pathways to Parkinsonism

2003 • 98 citations

Munc-18 Associates with Syntaxin and Serves as a Negative Regulator of Exocytosis in the Pancreatic β-Cell

2000 • 89 citations

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

2001 • 85 citations

Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex

1993 • 72 citations

Association of IgM type anti‐GM1 antibodies and muscle strength in chronic acquired demylelinating polyneuropathy

1998 • 65 citations

Localization of a novel septin protein, hCDCrel-1, in neurons of human brain

1998 • 49 citations

Overexpression of Parkinson's disease‐associated α‐Synuclein^A53T by recombinant adeno‐associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP

2002 • 45 citations

Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/Calmodulin kinase II inhibitor KN-62

1995 • 38 citations

[52] Expression and analysis of properties of septin CDCrel-1 in exocytosis

2001 • 30 citations