Membrane Association and Targeting of Prenylated Ras-like GTPases

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Protein Prenyltransferases

1996 • 693 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane

1996 • 449 citations

Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.

1994 • 425 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Rab GTPases in vesicular transport

1993 • 379 citations

Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis

1997 • 351 citations

Myristoylation

1997 • 350 citations

Protein Prenylation: a Mediator of Protein-Protein Interactions

1993 • 346 citations

Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

1997 • 328 citations

Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase

1993 • 325 citations

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

1992 • 323 citations

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

1993 • 322 citations

Rab GTPases: master regulators of membrane trafficking

1994 • 315 citations

Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange

1994 • 313 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

Role of Protein Modification Reactions in Programming Interactions Between Ras-Related GTPases and Cell Membranes

1994 • 279 citations

The Ras superfamily of GTPases ¹

1996 • 269 citations

Fluorometric Evaluation of the Affinities of Isoprenylated Peptides for Lipid Bilayers

1994 • 253 citations

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.

1994 • 230 citations

Endosome dynamics regulated by a Rho protein

1996 • 225 citations

Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI

1997 • 218 citations

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

1996 • 217 citations

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

1991 • 169 citations

Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex

1994 • 167 citations

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

1995 • 144 citations

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

1994 • 139 citations

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

1991 • 128 citations

Mammalian Protein Geranylgeranyltransferase-I: Substrate Specificity, Kinetic Mechanism, Metal Requirements, and Affinity Labeling

1995 • 122 citations

Structural insights into the function of the Rab GDI superfamily

1996 • 111 citations

Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase

1997 • 97 citations

Mechanism of Digeranylgeranylation of Rab Proteins

1996 • 95 citations

Ultrastructural localization of ras-related proteins using epitope-tagged plasmids.

1995 • 70 citations

Association of Rab1B with GDP-dissociation Inhibitor (GDI) Is Required for Recycling but Not Initial Membrane Targeting of the Rab Protein

1996 • 70 citations

Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif.

1992 • 68 citations

New insights into the pathogenesis of choroideremia: a tale of two REPs

1996 • 60 citations

Nucleotide Dependence of Rab Geranylgeranylation

1996 • 60 citations

Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.

1994 • 59 citations

Geranylgeranylation of Rab proteins

1996 • 56 citations

Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane

1997 • 51 citations

Genes Encoding Farnesyl Cysteine Carboxyl Methyltransferase inSchizosaccharomyces pombeandXenopus laevis

1997 • 40 citations

A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide

1993 • 32 citations

GDP Dissociation Inhibitor Serves as a Cytosolic Acceptor for Newly Synthesized and Prenylated Rab5

1995 • 25 citations

Chemical biology of isoprenylation/methylation

1996 • 23 citations

Endoproteolysis of non‐CAAX‐containing isoprenylated peptides

1993 • 12 citations