Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase

1993 • 325 citations

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

1992 • 323 citations

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

1993 • 322 citations

Cloning of a gene that is rearranged in patients with choroideraemia

1990 • 318 citations

Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product

1992 • 296 citations

Role of Protein Modification Reactions in Programming Interactions Between Ras-Related GTPases and Cell Membranes

1994 • 279 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

G-protein-coupled receptor kinases

1991 • 219 citations

REP-2, a Rab escort protein encoded by the choroideremia-like gene.

1994 • 183 citations

Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

1991 • 177 citations

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

1991 • 169 citations

A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein.

1988 • 138 citations

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.

1992 • 136 citations

Dependence of Ypt1 and Sec4 membrane attachment on Bet2

1991 • 118 citations

rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif

1991 • 102 citations

Post-translational processing of Schizosaccharomyces pombe YPT proteins.

1992 • 68 citations

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.

1994 • 61 citations

p23rab2, a ras-like GTPase with a -GGGCC C-terminus, is isoprenylated but not detectably carboxymethylated in NIH3T3 cells.

1992 • 35 citations

Post-translational processing of Schizosaccharomyces pombe YPT5 protein. In vitro and in vivo analysis of processing mutants.

1993 • 22 citations