Splicing Speckles Are Not Reservoirs of RNA Polymerase II, but Contain an Inactive Form, Phosphorylated on Serine²Residues of the C-Terminal Domain

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

An extensive network of coupling among gene expression machines

2002 • 1,137 citations

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

2000 • 1,049 citations

Nuclear speckles: a model for nuclear organelles

2003 • 955 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

1996 • 559 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Paraspeckles

2002 • 500 citations

Active RNA polymerases are localized within discrete transcription ‘factories’ in human nuclei

1996 • 445 citations

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

2001 • 421 citations

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

1992 • 402 citations

Dynamic association of capping enzymes with transcribing RNA polymerase II

2000 • 384 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.

1996 • 324 citations

RNA Polymerase II Targets Pre-mRNA Splicing Factors to Transcription Sites In Vivo

1999 • 322 citations

Functional Interaction of Yeast Pre-mRNA 3′ End Processing Factors with RNA Polymerase II

2002 • 306 citations

Numbers and Organization of RNA Polymerases, Nascent Transcripts, and Transcription Units in HeLa Nuclei

1998 • 292 citations

Purification and biochemical characterization of interchromatin granule clusters

1999 • 285 citations

The transcription cycle of RNA polymerase II in living cells

2002 • 269 citations

Ultrastructural Analysis of Transcription and Splicing in the Cell Nucleus after Bromo-UTP Microinjection

1999 • 256 citations

Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III

1999 • 252 citations

In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin

1996 • 249 citations

Cajal Bodies, Nucleoli, and Speckles in the Xenopus Oocyte Nucleus Have a Low-Density, Sponge-like Structure

2004 • 242 citations

Phosphorylated RNA polymerase II stimulates pre-mRNA splicing

1999 • 239 citations

Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II

1998 • 225 citations

Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II

1997 • 217 citations

P54nrb Forms a Heterodimer with PSP1 That Localizes to Paraspeckles in an RNA-dependent Manner

2005 • 216 citations

Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity

1997 • 197 citations

Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains

2003 • 196 citations

Splicing and transcription-associated proteins PSF and p54nrb/NonO bind to the RNA polymerase II CTD

2002 • 191 citations

Regulation of transcription elongation by phosphorylation

2002 • 188 citations

p54nrb associates with the 5′ splice site within large transcription/splicing complexes

2004 • 176 citations

Reduced Mobility of the Alternate Splicing Factor (Asf) through the Nucleoplasm and Steady State Speckle Compartments

2000 • 175 citations

Tracking Col1a1 RNA in Osteogenesis Imperfecta

2000 • 164 citations

Three-Dimensional Visualization of Transcription Sites and Their Association with Splicing Factor–Rich Nuclear Speckles

1999 • 157 citations

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription.

1997 • 141 citations

The link between mRNA processing and transcription: communication works both ways

2004 • 139 citations

Ultrastructure of the Nucleus in Relation to Transcription and Splicing: Roles of Perichromatin Fibrils and Interchromatin Granules

1996 • 129 citations

C-terminal Repeat Domain Kinase I Phosphorylates Ser2 and Ser5 of RNA Polymerase II C-terminal Domain Repeats

2004 • 128 citations

RNA Polymerase II Carboxy-Terminal Domain Phosphorylation Is Required for Cotranscriptional Pre-mRNA Splicing and 3′-End Formation

2004 • 125 citations

Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells

2004 • 125 citations

The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions

2001 • 124 citations

Quantitative Digital Analysis of Diffuse and Concentrated Nuclear Distributions of Nascent Transcripts, SC35 and Poly(A)

1997 • 114 citations

Repositioning of Muscle-specific Genes Relative to the Periphery of SC-35 Domains during Skeletal Myogenesis

2003 • 95 citations

Coiled Bodies and U2 snRNA Genes Adjacent to Coiled Bodies Are Enriched in Factors Required for snRNA Transcription

1998 • 86 citations

Interaction between the Shuttling mRNA Export Factor Gle1 and the Nucleoporin hCG1: A Conserved Mechanism in the Export of Hsp70 mRNA

2005 • 80 citations

Compartmentalization of RNA Processing Factors within Nuclear Speckles

2000 • 78 citations

Participation of the C-Terminal Domain of RNA Polymerase II in Exon Definition during Pre-mRNA Splicing

2000 • 75 citations

Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains

2002 • 71 citations

Dynamics of Transcription and Pre-mRNA Splicing within the Mammalian Cell Nucleus

1993 • 65 citations

The path of transcripts from extra-nucleolar synthetic sites to nuclear pores: transcripts in transit are concentrated in discrete structures containing SR proteins

1998 • 65 citations

Fixation-induced redistribution of hyperphosphorylated RNA polymerase II in the nucleus of human cells

2004 • 61 citations

Cytostellin: A novel, highly conserved protein that undergoes continuous redistribution during the cell cycle

1992 • 57 citations

Mammalian cell lines expressing functional RNA polymerase II tagged with the green fluorescent protein

2000 • 56 citations

Bridging the Resolution Gap: Imaging the Same Transcription Factories in Cryosections by Light and Electron Microscopy

1999 • 55 citations

The distribution of RNA polymerase II largest subunit (RPB1) in the Xenopus germinal vesicle

2002 • 49 citations

Colocalization of a high molecular mass phosphoprotein of the nuclear matrix (p255) with spliceosomes

1995 • 40 citations

Expression and Functional Significance of Mouse Paraspeckle Protein 1 on Spermatogenesis1

2004 • 40 citations

Multifunctional compartments in the nucleus: Insights from DNA and RNA localization

1996 • 38 citations

Distribution of different phosphorylated forms of RNA polymerase II in relation to Cajal and PML bodies in human cells: an ultrastructural study

2005 • 36 citations

Cytostellin distributes to nuclear regions enriched with splicing factors

1994 • 34 citations

Isolation and Characterization of Monoclonal Antibodies Directed against Subunits of Human RNA Polymerases I, II, and III

2000 • 22 citations

Heat shock-induced alterations in phosphorylation of the largest subunit of RNA polymerase II as revealed by monoclonal antibodies CC-3 and MPM-2

1999 • 8 citations