Active RNA polymerases are localized within discrete transcription ‘factories’ in human nuclei

Histochemistry: Theoretical and Applied

1953 • 7,198 citations

Immunochemistry on ultrathin frozen sections

1980 • 755 citations

RNA POLYMERASE II

1991 • 729 citations

Fine Structure Immunocytochemistry

1993 • 707 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

Visualization of replication factories attached to a nucleoskeleton

1993 • 472 citations

On the preparation of cryosections for immunocytochemistry

1984 • 468 citations

Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus

1986 • 436 citations

Progression of the cell cycle through mitosis leads to abortion of nascent transcripts

1991 • 379 citations

Molecular biology of the cell (3rd edn)

1995 • 346 citations

The Ultrastructural Visualization of Nucleolar and Extranucleolar RNA Synthesis and Distribution

1980 • 344 citations

A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus

1993 • 335 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells

1995 • 315 citations

Transcription occurs at a nucleoskeleton.

1985 • 303 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

RNA is synthesized at the nuclear cage

1981 • 250 citations

Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery.

1991 • 243 citations

Units of transcription and translation: Sequence components of heterogeneous nuclear RNA and messenger RNA

1975 • 226 citations

Visualization of a filamentous nucleoskeleton with a 23 nm axial repeat.

1988 • 216 citations

Site of transcription of ribosomal RNA and intranucleolar structure in HeLa cells

1994 • 214 citations

Anionic regions in nuclear proteins.

1987 • 167 citations

A general method for preparing chromatin containing intact DNA.

1985 • 161 citations

The DNA‐Binding Efficiency of Sp1 is Affected by Redox Changes

1994 • 156 citations

A gentle method for preparing cyto- and nucleo-skeletons and associated chromatin

1988 • 155 citations

Quantitation of elongating form A and B RNA polymerases in chick oviduct nuclei and effects of estradiol

1976 • 140 citations

Footprinting analysis of mammalian RNA polymerase II along its transcript: an alternative view of transcription elongation.

1991 • 92 citations

Immunochemical analysis of mammalian RNA polymerase II subspecies. Stability and relative in vivo concentration.

1986 • 89 citations

Identification of Residues in the Human DNA Repair Enzyme HAP1 (Ref-1) That are Essential for Redox Regulation of Jun DNA Binding

1993 • 84 citations

Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus.

1986 • 72 citations

Dynamics of Transcription and Pre-mRNA Splicing within the Mammalian Cell Nucleus

1993 • 65 citations

Regulated secretion of mature cathepsin B from rat exocrine pancreatic cells.

1991 • 60 citations

Hypothesis: RNA polymerase: Structural determinat of the chromatin loop and the chromosome

1994 • 58 citations

Localization of Carbohydrate-Containing Molecules

1986 • 40 citations

In vitro splicing of pre-mRNA containing bromouridine

1994 • 38 citations

Confocal microscopy and image processing in the study of plant nuclear structure

1992 • 19 citations

Bismuth staining of a nucleolar protein

1984 • 16 citations

[50] Nucleolar-specific positive stains for optical and electron microscopy

1991 • 7 citations

Stereological Techniques

2013 • 4 citations

Transcription by RNA Polymerase II and Nuclear Architecture

1997 • 4 citations