C-terminal Repeat Domain Kinase I Phosphorylates Ser2 and Ser5 of RNA Polymerase II C-terminal Domain Repeats

Integrating mRNA Processing with Transcription

2002 • 1,054 citations

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

2000 • 1,049 citations

P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II

2000 • 671 citations

5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II

1997 • 540 citations

Phosphorylation of Serine 2 within the RNA Polymerase II C-Terminal Domain Couples Transcription and 3′ End Processing

2004 • 506 citations

mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain

1997 • 467 citations

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

2001 • 421 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

1998 • 400 citations

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

2003 • 400 citations

Dynamic association of capping enzymes with transcribing RNA polymerase II

2000 • 384 citations

Distinct Roles for CTD Ser-2 and Ser-5 Phosphorylation in the Recruitment and Allosteric Activation of Mammalian mRNA Capping Enzyme

1999 • 329 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

Functional Interaction of Yeast Pre-mRNA 3′ End Processing Factors with RNA Polymerase II

2002 • 306 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription

2000 • 260 citations

Coordination of Transcription, RNA Processing, and Surveillance by P-TEFb Kinase on Heat Shock Genes

2004 • 241 citations

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

1995 • 239 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock

2003 • 214 citations

Kin28, the TFIIH-Associated Carboxy-Terminal Domain Kinase, Facilitates the Recruitment of mRNA Processing Machinery to RNA Polymerase II

2000 • 200 citations

The Splicing Factor, Prp40, Binds the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II

2000 • 197 citations

Phosphorylation of the RNA Polymerase II Carboxyl-Terminal Domain by CDK9 Is Directly Responsible for Human Immunodeficiency Virus Type 1 Tat-Activated Transcriptional Elongation

2002 • 175 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

A Complex of the Srb8, -9, -10, and -11 Transcriptional Regulatory Proteins from Yeast

2002 • 166 citations

Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. Elution of active enzyme with protein stabilizing agents from a polyol-responsive monoclonal antibody.

1990 • 163 citations

Bur1 Kinase Is Required for Efficient Transcription Elongation by RNA Polymerase II

2003 • 155 citations

The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex

1995 • 140 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

Purification and lipid-layer crystallization of yeast RNA polymerase II.

1990 • 113 citations

Evolution of Cyclin-Dependent Kinases (CDKs) and CDK-Activating Kinases (CAKs): Differential Conservation of CAKs in Yeast and Metazoa

2000 • 110 citations

Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain by the Bur1 Cyclin-Dependent Kinase

2001 • 98 citations

Modulation of RNA Polymerase II Elongation Efficiency by C-terminal Heptapeptide Repeat Domain Kinase I

1997 • 97 citations

Transcription-dependent Structural Changes in the C-terminal Domain of Mammalian RNA Polymerase Subunit IIa/o

1989 • 97 citations

Genetic Interactions of Spt4-Spt5 and TFIIS With the RNA Polymerase II CTD and CTD Modifying Enzymes in Saccharomyces cerevisiae

2001 • 91 citations

Conformation of the RNA polymerase II C-terminal domain: circular dichroism of long and short fragments

2000 • 82 citations

RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.

1993 • 81 citations

RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes

2003 • 81 citations

SGV1 encodes a CDC28/cdc2-related kinase required for a Gα subunit-mediated adaptive response to pheromone in S. cerevisiae

1991 • 79 citations

Yeast Carboxyl-terminal Domain Kinase I Positively and Negatively Regulates RNA Polymerase II Carboxyl-terminal Domain Phosphorylation

1999 • 68 citations

The RNA Polymerase II CTD Kinase CTDK-I Affects Pre-mRNA 3′ Cleavage/Polyadenylation through the Processing Component Pti1p

2002 • 50 citations

Budding Yeast CTDK-I Is Required for DNA Damage-Induced Transcription

2003 • 50 citations

Suppression Analysis Reveals a Functional Difference Between the Serines in Positions Two and Five in the Consensus Sequence of the C-Terminal Domain of Yeast RNA Polymerase II

1996 • 47 citations

A Strategy for the Rapid Identification of Phosphorylation Sites in the Phosphoproteome

2002 • 46 citations

Optimization of the resolution of phosphoamino acids by one-dimensional thin-layer electrophoresis.

1993 • 29 citations

Assaying CTD Kinasesin Vitroand Phosphorylation-Modulated Properties of RNA Polymerase IIin Vivo

1997 • 23 citations