Dual Role for Nitric Oxide in Dynorphin Spinal Neurotoxicity

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Nitric Oxide Signaling in the Central Nervous System

1995 • 1,628 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.

1992 • 798 citations

Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation

1994 • 669 citations

Nitric oxide and the cerebral circulation.

1994 • 540 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Nitric Oxide in the Nervous System

1995 • 503 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Potential genotoxicity of chronically elevated nitric oxide: A review

1995 • 385 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Nitric Oxide in the Regulation of Blood Flow and Arterial Pressure

1995 • 287 citations

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

1995 • 283 citations

Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia

1995 • 220 citations

Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after local cerebral ischemia in rat

1994 • 200 citations

Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells

1993 • 192 citations

Local nitric oxide production in viral and autoimmune diseases of the central nervous system.

1995 • 185 citations

Aminoguanidine Ameliorates and <scp>l</scp> -Arginine Worsens Brain Damage From Intraluminal Middle Cerebral Artery Occlusion

1996 • 184 citations

Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury

1994 • 184 citations

The Complex Role of Nitric Oxide in the Pathophysiology of Focal Cerebral Ischemia

1994 • 176 citations

Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy

1993 • 171 citations

Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons

1992 • 152 citations

Nitric Oxide Synthase Activity Endogenously Modulates NMDA Receptors

1993 • 151 citations

Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion

1995 • 126 citations

Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury

1990 • 126 citations

Molecular Mechanisms of Nitric Oxide Actions in the Brain^a

1994 • 115 citations

Axotomy-Induced Apoptotic Cell Death of Neonatal Rat Facial Motoneurons: Time Course Analysis and Relation to NADPH-Diaphorase Activity

1996 • 108 citations

Reduction of Focal Cerebral Ischemic Damage by Delayed Treatment with Nitric Oxide Donors

1994 • 106 citations

Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors

1996 • 100 citations

Non-opioid effects of dynorphins: possible role of the NMDA receptor

1994 • 99 citations

7-Nitroindazole Inhibits Brain Nitric Oxide Synthase and Cerebral Vasodilatation in Response to N -Methyl- <scp>d</scp> -aspartate

1995 • 92 citations

Electron paramagnetic resonance study on nitric oxide production during brain focal ischemia and reperfusion in the rat

1994 • 86 citations

A direct non-opiate interaction of dynorphin-(1–13) with the N-methyl-D-aspartate (NMDA) receptor

1989 • 83 citations

Competitive and non-competitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis

1990 • 80 citations

Three-Dimensional Imaging of Nitric Oxide Production in the Rat Brain Subjected to Ischemia—Hypoxia

1995 • 79 citations

Time Dependence of Effect of Nitric Oxide Synthase Inhibition on Cerebral Ischemic Damage

1995 • 79 citations

Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-d-aspartate neurotoxicity

1993 • 73 citations

Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats.

1994 • 63 citations

Dynorphin A-induced rat spinal cord injury: evidence for excitatory amino acid involvement in a pharmacological model of ischemic spinal cord injury.

1994 • 54 citations

A Comparison of YM-14673, U-50488H, and Nalmefene after Spinal Cord Injury in the Rat

1993 • 49 citations

Antagonism by Ng-nitro-l-arginine ofl-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy

1993 • 49 citations

κ-Selective Opiate Antagonist Nor-Binaltorphimine Improves Outcome After Traumatic Spinal Cord Injury in Rats

1987 • 45 citations

Evidence for bidirectional changes in nitric oxide synthase activity in the rat striatum after excitotoxically (quinolinic acid) induced degeneration

1995 • 45 citations

Delayed production of nitric oxide contributes to NMDA-mediated neuronal damage

1993 • 42 citations

Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors

1996 • 37 citations

Selective involvement of kappa opioid and phencyclidine receptors in the analgesic and motor effects of dynorphin-A-(1–13)-Tyr-Leu-Phe-Asn-Gly-Pro

1992 • 36 citations

A Dual Role for Nitric Oxide in NMDA-Mediated Toxicity in vivo

1995 • 33 citations

1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury

1994 • 32 citations

Dynorphin potentiation of [3H]CGP-39653 binding to rat brain membranes

1994 • 31 citations

The effect of nitric oxide synthase inhibition on quinolinic acid toxicity in the rat striatum

1995 • 26 citations

Mechanism of the dynorphin-induced dualistic effect on free intracellular Ca2+ concentration in cultured rat spinal neurons

1998 • 15 citations

Profiles of the Antinociceptive Effect of R-84760, a Selective κ-Opioid Receptor Agonist, in the Formalin Test in Mice

1995 • 6 citations