A Dual Role for Nitric Oxide in NMDA-Mediated Toxicity in vivo

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Effect of Ischemia on the In Vivo Release of Striatal Dopamine, Glutamate, and γ‐Aminobutyric Acid Studied by Intracerebral Microdialysis

1988 • 704 citations

Insulin effects on monovalent cation transport and Na-K-ATPase activity

1978 • 692 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain.

1993 • 339 citations

NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathway

1991 • 301 citations

Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

1992 • 239 citations

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

1992 • 237 citations

Glutamate Receptor Agonists Stimulate Nitric Oxide Synthase in Primary Cultures of Cerebellar Granule Cells

1992 • 234 citations

Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

1993 • 223 citations

Nitric oxide inhibitors attenuate excitotoxicity in rat hippocampal slices

1992 • 174 citations

Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

1993 • 171 citations

Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat

1991 • 169 citations

Inhibition of Nitric Oxide Synthase Blocks N‐Methyl‐D‐Aspartate‐, Quisqualate‐, Kainate‐, Harmaline‐, and Pentylenetetrazole‐Dependent Increases in Cerebellar Cyclic GMP In Vivo

1990 • 148 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Effects of Endothelium-Derived Nitric Oxide on Cerebral Circulation during Normoxia and Hypoxia in the Rat

1992 • 140 citations

Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions

1992 • 129 citations

Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels

1990 • 121 citations

Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia

1992 • 119 citations

Registration and three-dimensional reconstruction of autoradiographic images by the disparity analysis method

1993 • 84 citations

Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus

1992 • 84 citations

Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia

1991 • 82 citations

Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-d-aspartate neurotoxicity

1993 • 73 citations

Absence of N-Methyl-D-Aspartate Receptors on Ovine Cerebral Microvessels

1988 • 72 citations

Reduction of striatal N-methyl-d-aspartate toxicity by inhibition of nitric oxide synthase

1993 • 59 citations

Cerebrovascular Diseases (Sixteenth Research [Princeton] Conference)

1990 • 27 citations