Aging and cancer: are telomeres and telomerase the connection?

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

1978 • 1,003 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Correlating telomerase activity levels with human neuroblastoma outcomes

1995 • 631 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

1989 • 481 citations

Telomerase Activity in Small-Cell and Non-Small-Cell Lung Cancers

1995 • 447 citations

Telomerase activity in gastric cancer.

1995 • 433 citations

The remaking of chromosomes

1938 • 416 citations

Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)

1995 • 395 citations

Functional Characterization and Developmental Regulation of Mouse Telomerase RNA

1995 • 366 citations

Telomerase activity associated with acquisition of malignancy in human colorectal cancer.

1995 • 361 citations

Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas.

1995 • 313 citations

Telomeres, telomerase and senescence

1990 • 260 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

Telomere positional effects and the regulation of cellular senescence

1992 • 246 citations

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

1986 • 229 citations

E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts.

1993 • 202 citations

Telomeric repeat from T. thermophila cross hybridizes with human telomeres

1988 • 190 citations

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

1995 • 121 citations