Hydrogen Peroxide Signaling through Tumor Necrosis Factor Receptor 1 Leads to Selective Activation of c-Jun N-terminal Kinase

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

2002 • 1,141 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

2001 • 478 citations

Reactive oxygen generated by Nox1 triggers the angiogenic switch

2002 • 473 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90

2002 • 393 citations

Evidence that reactive oxygen species do not mediate NF- B activation

2003 • 385 citations

Oxidant-induced DNA damage of target cells.

1988 • 382 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation

2000 • 328 citations

Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase

2001 • 323 citations

Anatomy of TRAF2

1996 • 302 citations

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

2003 • 253 citations

Reactive oxygen intermediates in TNF signaling

2002 • 228 citations

Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

2003 • 209 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation

2001 • 199 citations

Cytokine-induced Activation of Nuclear Factor-κB Is Inhibited by Hydrogen Peroxide through Oxidative Inactivation of IκB Kinase

2001 • 189 citations

Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts

2002 • 161 citations

Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium.

1990 • 148 citations

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

2002 • 138 citations

Rac1 is required for cell proliferation and G2/M progression

1997 • 73 citations

Hydrogen Peroxide Enhances Shedding of Type I Soluble Tumor Necrosis Factor Receptor from Pulmonary Epithelial Cells

1999 • 33 citations

Ultraviolet Light-induced Stimulation of the JNK Mitogen-activated Protein Kinase in the Absence of Src Family Tyrosine Kinase Activation

2000 • 6 citations