Ultraviolet Light-induced Stimulation of the JNK Mitogen-activated Protein Kinase in the Absence of Src Family Tyrosine Kinase Activation

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

The SOS regulatory system of Escherichia coli

1982 • 1,491 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Characterization of EBV‐genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non‐Hodgkin lymphoma

1977 • 698 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

Ionizing radiation regulates expression of the c-jun protooncogene.

1990 • 297 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

UV-induced signal transduction

1997 • 277 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

Activation of mammalian gene expression by the UV component of sunlight – from models to reality

1996 • 243 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

p493F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system

1995 • 206 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1995 • 179 citations

Two E‐rosette‐forming lymphoid cell lines

1978 • 169 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells

1996 • 127 citations

Cooperation between Syk and Rac1 Leads to Synergistic JNK Activation in T Lymphocytes

1998 • 125 citations

Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells.

1984 • 121 citations

Antioxidants Inhibit Stimulation of HIV Transcription

1993 • 114 citations

Oxidative stress is involved in the UV activation of p53

1996 • 114 citations

Palmitoylation of Either Cys-3 or Cys-5 Is Required for the Biological Activity of the Lck Tyrosine Protein Kinase

1995 • 98 citations

TNF Receptor p55 Plays a Pivotal Role in Murine Keratinocyte Apoptosis Induced by Ultraviolet B Irradiation

1999 • 85 citations

Analysis of the activity and phosphorylation of the lck protein in lymphoid cells.

1989 • 68 citations

Two lck Transcripts Containing Different 5′ Untranslated Regions are Present in T Cells

1987 • 63 citations

The lck tyrosine protein kinase.

1991 • 62 citations

Oxidant, Antioxidant Status and Photocarcinogenesis: The Role of Gene Activation

1996 • 48 citations

Stimulation of Phosphorylation of Tyr394 by Hydrogen Peroxide Reactivates Biologically Inactive, Non-membrane-bound Forms of Lck

1996 • 30 citations

Cellular responses to DNA damage.

1985 • 14 citations