MAP kinases and cell migration

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

The MAPK signaling cascade

1995 • 3,300 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Cells lying on a bed of microneedles: An approach to isolate mechanical force

2003 • 1,919 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

2004 • 1,330 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein

1998 • 1,019 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

Paxillin and focal adhesion signalling

2000 • 765 citations

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

2001 • 724 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

LIM domains: multiple roles as adapters and functional modifiers in protein interactions

1998 • 592 citations

Biochemical signals and biological responses elicited by the focal adhesion kinase

2001 • 568 citations

p38 MAPK signalling cascades in inflammatory disease

1999 • 552 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Paxillin: a focal adhesion-associated adaptor protein

2001 • 520 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity.

1994 • 493 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

JNK phosphorylates paxillin and regulates cell migration

2003 • 461 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.

1991 • 445 citations

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

2003 • 435 citations

p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration

2002 • 431 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1999 • 401 citations

Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

1998 • 397 citations

Role of microtubule-associated proteins in the control of microtubule assembly

1995 • 396 citations

Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts

2004 • 395 citations

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

1997 • 386 citations

Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells

2001 • 381 citations

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

2003 • 368 citations

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.

1996 • 365 citations

Matrix Survival Signaling

2000 • 360 citations

Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 • 353 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

p38 and ERK1/2 Coordinate Cellular Migration and Proliferation in Epithelial Wound Healing

2003 • 333 citations

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1998 • 327 citations

Binding of paxillin to α4 integrins modifies integrin-dependent biological responses

1999 • 326 citations

The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling

2002 • 320 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

1996 • 310 citations

Myosin Light Chain Kinase Functions Downstream of Ras/ERK to Promote Migration of Urokinase-Type Plasminogen Activator-Stimulated Cells in an Integrin-Selective Manner

1999 • 306 citations

The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration

2003 • 292 citations

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

2000 • 279 citations

Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.

1995 • 279 citations

Extracellular-Regulated Kinase Activation and Cas/Crk Coupling Regulate Cell Migration and Suppress Apoptosis during Invasion of the Extracellular Matrix

2000 • 275 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle

1999 • 275 citations

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)

2001 • 267 citations

Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation

2004 • 265 citations

Doublecortin, a Stabilizer of Microtubules

1999 • 263 citations

Regulation of Cell Contraction and Membrane Ruffling by Distinct Signals in Migratory Cells

1999 • 260 citations

Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility

2004 • 256 citations

Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

2001 • 250 citations

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells.

2001 • 249 citations

The control of cell motility and epithelial morphogenesis by Jun kinases

2004 • 243 citations

MEK kinase 1 gene disruption alters cell migration and c-Jun NH ₂ -terminal kinase regulation but does not cause a measurable defect in NF-κB activation

2000 • 240 citations

EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathway

1998 • 231 citations

Distinct Cellular Functions of MK2

2002 • 229 citations

5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

2000 • 216 citations

DCX, a new mediator of the JNK pathway

2004 • 215 citations

Phosphorylation-Dependent Paxillin-ERK Association Mediates Hepatocyte Growth Factor-Stimulated Epithelial Morphogenesis

2003 • 214 citations

A Novel Role for FAK as a Protease-Targeting Adaptor Protein

2003 • 194 citations

Dual Roles for c-Jun N-Terminal Kinase in Developmental and Stress Responses in Cerebellar Granule Neurons

2000 • 192 citations

Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues

2001 • 180 citations

A role for MEK kinase 1 in TGF- /activin-induced epithelium movement and embryonic eyelid closure

2003 • 176 citations

Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

1997 • 173 citations

Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration

1999 • 171 citations

Trophic Factor Withdrawal: p38 Mitogen-Activated Protein Kinase Activates NHE1, Which Induces Intracellular Alkalinization

2001 • 165 citations

Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and Matrigel invasion

2000 • 164 citations

Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion

2001 • 158 citations

Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis.

2002 • 151 citations

Distinct Roles of Frontal and Rear Cell-Substrate Adhesions in Fibroblast Migration

2001 • 143 citations

Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association

2002 • 143 citations

Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway

2003 • 140 citations

JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila

2000 • 131 citations

Novel Mechanism for Gonadotropin-Releasing Hormone Neuronal Migration Involving Gas6/Ark Signaling to p38 Mitogen-Activated Protein Kinase

2002 • 126 citations

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts

2003 • 125 citations

Disruption of Basal JNK Activity Differentially Affects Key Fibroblast Functions Important for Wound Healing

2003 • 119 citations

Planar polarity and actin dynamics in the epidermis of Drosophila

2002 • 118 citations

The Genomic Response of the Drosophila Embryo to JNK Signaling

2001 • 114 citations

Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin

1997 • 112 citations

The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

1984 • 112 citations

ERK, JNK, and p38 MAP kinases differentially regulate proliferation and migration of phenotypically distinct smooth muscle cell subtypes

2003 • 105 citations

The Intermediate Filament Protein Keratin 8 Is a Novel Cytoplasmic Substrate for c-Jun N-terminal Kinase

2002 • 105 citations

The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization

2000 • 101 citations

Bombesin, Lysophosphatidic Acid, and Epidermal Growth Factor Rapidly Stimulate Focal Adhesion Kinase Phosphorylation at Ser-910

2003 • 99 citations

Urokinase/urokinase receptor and vitronectin/αvβ3 integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways

2001 • 97 citations

Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell Migration

2002 • 97 citations

c-Jun N-terminal Kinase Specifically Phosphorylates p66ShcA at Serine 36 in Response to Ultraviolet Irradiation

2001 • 96 citations

MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions

1999 • 93 citations

Natriuretic Peptides Suppress Vascular Endothelial Cell Growth Factor Signaling to Angiogenesis*

2001 • 91 citations

Activated Ras induces a proangiogenic phenotype in primary endothelial cells

2004 • 89 citations

Serine Phosphorylation of Focal Adhesion Kinase in Interphase and Mitosis: A Possible Role in Modulating Binding to p130^Cas

2001 • 88 citations

α2 Integrin Subunit Cytoplasmic Domain-dependent Cellular Migration Requires p38 MAPK

2001 • 88 citations

C-reactive Protein Inhibits Chemotactic Peptide-induced p38 Mitogen-activated Protein Kinase Activity and Human Neutrophil Movement

1999 • 88 citations

UVA Induces Ser381 Phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK Pathways

2001 • 84 citations

A Role for JNK-Paxillin Signaling in Cell Migration

2004 • 82 citations

Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells

2004 • 79 citations

Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling

2002 • 75 citations

Microscope-based techniques to study cell adhesion and migration

2002 • 74 citations

Abnormal Migration Phenotype of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2−/− Neutrophils in Zigmond Chambers Containing Formyl-Methionyl-Leucyl-Phenylalanine Gradients

2001 • 74 citations

Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G Protein

1999 • 68 citations

Sensitized Mast Cells Migrate Toward the Agen: A Response Regulated by p38 Mitogen-Activated Protein Kinase and Rho-Associated Coiled-Coil-Forming Protein Kinase

2001 • 67 citations

Identification of the p16-Arc Subunit of the Arp 2/3 Complex as a Substrate of MAPK-activated Protein Kinase 2 by Proteomic Analysis

2003 • 66 citations

Serine phosphorylation of paxillin by heregulin-β1: role of p38 mitogen activated protein kinase

1999 • 66 citations

The Role of Mitogen-Activated Protein Kinase Activation within Focal Adhesions in Chemotaxis toward FGF-2 by Murine Brain Capillary Endothelial Cells

2001 • 66 citations

Activation of p38 MAP-Kinase and Caldesmon Phosphorylation Are Essential for Urokinase-Induced Human Smooth Muscle Cell Migration

2002 • 63 citations

PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation

2003 • 59 citations

c-Jun N-terminal kinase is involved in motility of endothelial cell

2001 • 56 citations

blisteryencodesDrosophilatensin protein and interacts with integrin and the JNK signaling pathway during wing development

2003 • 49 citations

Stem Cell Factor-Induced Migration of Mast Cells Requires p38 Mitogen-Activated Protein Kinase Activity

2001 • 45 citations

Constitutive JNK Activation in NIH 3T3 Fibroblasts Induces a Partially Transformed Phenotype

2002 • 43 citations

A Microtubule-associated Protein (MAP2) Kinase Restores Microtubule Motility in Embryonic Brain

1995 • 39 citations

MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression

2003 • 38 citations

c‐Jun N‐terminal kinase‐3 (JNK3)/stress‐activated protein kinase‐β (SAPKβ) binds and phosphorylates the neuronal microtubule regulator SCG10

2001 • 34 citations

Tensin Can Induce JNK and p38 Activation

2000 • 25 citations

Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice

2001 • 20 citations