TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

G-protein-coupled receptors and signaling networks: emerging paradigms

2001 • 1,005 citations

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

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Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

Ras and Rho GTPases

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Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

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MEMBRANE-ANCHORED GROWTH FACTORS

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Signal characteristics of G protein-transactivated EGF receptor

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

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TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

1998 • 569 citations

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

1999 • 551 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

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Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

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cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

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Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

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Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

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The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

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The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3

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Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

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Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

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The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors

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Extracellular Signal-regulated Kinase Phosphorylates Tumor Necrosis Factor α-converting Enzyme at Threonine 735: A Potential Role in Regulated Shedding

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Activation of MAPKs by Angiotensin II in Vascular Smooth Muscle Cells

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Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways

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A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin.

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Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.

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Mice Lacking the Metalloprotease-Disintegrin MDC9 (ADAM9) Have No Evident Major Abnormalities during Development or Adult Life

2002 • 209 citations

Angiotensin AT ₁ and AT ₂ Receptors Differentially Regulate Angiopoietin-2 and Vascular Endothelial Growth Factor Expression and Angiogenesis by Modulating Heparin Binding–Epidermal Growth Factor (EGF)–Mediated EGF Receptor Transactivation

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Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling

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cag+ Helicobacter pylori Induce Transactivation of the Epidermal Growth Factor Receptor in AGS Gastric Epithelial Cells

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Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activity

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Metalloprotease-dependent Protransforming Growth Factor-α Ectodomain Shedding in the Absence of Tumor Necrosis Factor-α-converting Enzyme

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Transactivation of the Epidermal Growth Factor Receptor in Colonic Epithelial Cells by Carbachol Requires Extracellular Release of Transforming Growth Factor-α

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A Dual Signaling Cascade That Regulates the Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor

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Inhibition of Apoptosis by Amphiregulin via an Insulin-like Growth Factor-1 Receptor-dependent Pathway in Non-small Cell Lung Cancer Cell Lines

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Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion.

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Role of EGF Receptor and Pyk2 in Endothelin-1-induced ERK Activation in Rat Cardiomyocytes

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EGF Receptor Transactivation Mediated by the Proteolytic Production of EGF-like Agonists

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A Heparin Sulfate-Regulated Human Keratinocyte Autocrine Factor Is Similar or Identical to Amphiregulin

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Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line

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Expression and regulation of c-erbB ligands in human head and neck squamous carcinoma cells

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A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops

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Multiple Calcium Stores: Separate but Interacting

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TGF-α antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo

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The Proamphiregulin Cytoplasmic Domain Is Required for Basolateral Sorting, but Is Not Essential for Constitutive or Stimulus-induced Processing in Polarized Madin-Darby Canine Kidney Cells

2001 • 40 citations

Inhibition of transforming growth factor alpha stimulation of human squamous cell carcinoma of the head and neck with anti-TGF-α antibodies and tyrphostin

1997 • 7 citations