A Nuclear 3′-5′ Exonuclease Involved in mRNA Degradation Interacts with Poly(A) Polymerase and the hnRNA Protein Npl3p

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

A new efficient gene disruption cassette for repeated use in budding yeast

1996 • 1,609 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases

1997 • 939 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex

1998 • 632 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

The yeast exosome and human PM-Scl are related complexes of 3' right-arrow 5' exonucleases

1999 • 433 citations

Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

1990 • 409 citations

RNA surveillance: unforeseen consequences for gene expression, inherited genetic disorders and cancer

1999 • 400 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Translational regulation in development

1995 • 394 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast

1996 • 377 citations

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

1995 • 374 citations

[16] Analyzing protein-protein interactions using two-hybrid system

1995 • 364 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Life and death in the cytoplasm: messages from the 3′ end

1997 • 335 citations

An essential component of the decapping enzyme required for normal rates of mRNA turnover

1996 • 328 citations

A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export.

1996 • 298 citations

Rrp6p, the Yeast Homologue of the Human PM-Scl 100-kDa Autoantigen, Is Essential for Efficient 5.8 S rRNA 3′ End Formation

1998 • 294 citations

Vectors for the inducible overexpression of glutathione S‐transferase fusion proteins in yeast

1993 • 284 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

Double-stranded RNA viruses of Saccharomyces cerevisiae

1996 • 252 citations

The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes

1998 • 241 citations

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1997 • 234 citations

Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast

1997 • 225 citations

Rat1p and Xrn1p Are Functionally Interchangeable Exoribonucleases That Are Restricted to and Required in the Nucleus and Cytoplasm, Respectively

1997 • 196 citations

[27] Gene identification using the yeast two-hybrid system

1996 • 195 citations

Comparative sequence analysis of ribonucleases HII, III, II PH and D

1997 • 183 citations

The Yeast Pan2 Protein Is Required for Poly(A)-binding Protein-stimulated Poly(A)-nuclease Activity

1996 • 182 citations

A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm.

1994 • 164 citations

Disruption of the gene XRN1, coding for a 5′→3′ exoribonuclease, restricts yeast cell growth

1990 • 152 citations

Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN.

1984 • 145 citations

Structure and function of the nontranscribed spacer regions of yeast rDNA

1984 • 139 citations

The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase

1995 • 136 citations

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

1994 • 133 citations

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

1995 • 132 citations

Decoying the Cap² mRNA Degradation System by a Double-Stranded RNA Virus and Poly(A)² mRNA Surveillance by a Yeast Antiviral System

1995 • 131 citations

RNA Processing Generates the Mature 3′ End of Yeast CYC1 Messenger RNA in Vitro

1988 • 129 citations

Cytoplasmic 3′ poly(A) addition induces 5′ cap ribose methylation: implications for translational control of maternal mRNA.

1995 • 107 citations

Yeast Virus Propagation Depends Critically on Free 60S Ribosomal Subunit Concentration

1995 • 107 citations

Nip7p Interacts with Nop8p, an Essential Nucleolar Protein Required for 60S Ribosome Biogenesis, and the Exosome Subunit Rrp43p

1999 • 99 citations

Synthetic Lethality of sep1 (xrn1) ski2 and sep1 (xrn1) ski3 Mutants of Saccharomyces cerevisiae Is Independent of Killer Virus and Suggests a General Role for These Genes in Translation Control

1995 • 97 citations

Potential RNA Binding Proteins in Saccharomyces cerevisiae Identified as Suppressors of Temperature-Sensitive Mutations in NPL3

1996 • 91 citations

Regulation and Intracellular Localization of Saccharomyces cerevisiae Strand Exchange Protein 1 (Sep1/Xrn1/Kem1), a Multifunctional Exonuclease

1995 • 88 citations

RNA Processing In Vitro Produces Mature 3′ Ends of a Variety of Saccharomyces cerevisiae mRNAs

1990 • 84 citations

Gene identification using the yeast two-hybrid system

1997 • 79 citations

A yeast protein that bidirectionally affects nucleocytoplasmic transport

1995 • 75 citations

Modifications of the 5′ Cap of mRNAs during Xenopus Oocyte Maturation: Independence from Changes in Poly(A) Length and Impact on Translation

1998 • 73 citations

Conditional Defect in mRNA 3′ End Processing Caused by a Mutation in the Gene for Poly(A) Polymerase

1992 • 70 citations

mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans

1998 • 66 citations

Ski6p Is a Homolog of RNA-Processing Enzymes That Affects Translation of Non-Poly(A) mRNAs and 60S Ribosomal Subunit Biogenesis

1998 • 63 citations

mRNA Formation and Function

1997 • 60 citations

Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae.

1994 • 49 citations

Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation

1998 • 47 citations

Mak21p of Saccharomyces cerevisiae, a Homolog of Human CAATT-binding Protein, Is Essential for 60 S Ribosomal Subunit Biogenesis

1998 • 39 citations

Escherichia coli RNase D. Catalytic properties and substrate specificity.

1981 • 38 citations

Ribosome Concentration Contributes to Discrimination against Poly(A)− mRNA during Translation Initiation in Saccharomyces cerevisiae

1997 • 37 citations

Ribosomal Association of Poly(A)-binding Protein in Poly(A)-deficient Saccharomyces cerevisiae

1996 • 34 citations

Escherichia coliRNase D: sequencing of therndstructural gene and purification of the overexpressed protein

1988 • 33 citations

The Uba2 and Ufd1 proteins of Saccharomyces cerevisiae interact with poly(A) polymerase and affect the polyadenylation activity of cell extracts

1997 • 33 citations

The exosome: A versatile RNA processing machine

1998 • 32 citations

RNA Polymerase III Defects Suppress a Conditional-Lethal Poly(A) Polymerase Mutation in Saccharomyces cerevisiae

1996 • 13 citations

Analysis of Polyadenylation Phenotypes in Saccharomyces cerevisiae

1997 • 4 citations