Rat1p and Xrn1p Are Functionally Interchangeable Exoribonucleases That Are Restricted to and Required in the Nucleus and Cytoplasm, Respectively

Methods in yeast genetics

1979 • 7,824 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Control of Messenger RNA Stability

1993 • 394 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.

1992 • 370 citations

A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

1997 • 341 citations

The 5′ end of yeast 5.8S rRNA is generated by exonucleases from an upstream cleavage site.

1994 • 308 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

Isolation and characterization of the gene encoding yeast debranching enzyme

1991 • 238 citations

The Mechanisms of mRNA Degradation in Eukaryotes

1999 • 204 citations

Purification and characterization of a Saccharomyces cerevisiae exoribonuclease which yields 5'-mononucleotides by a 5' leads to 3' mode of hydrolysis.

1980 • 188 citations

Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms.

1990 • 149 citations

Characterization of the XRN1 gene encoding a 5'→3' exoribonuclease: sequence data and analysis of disparate protein and mRNA levels of gene-disrupted yeast cells

1992 • 142 citations

The yeast KEM1 gene encodes a nuclease specific for G4 tetraplex DNA: Implication of in vivo functions for this novel DNA structure

1994 • 140 citations

Purification and characterization of an activity from Saccharomyces cerevisiae that catalyzes homologous pairing and strand exchange.

1987 • 132 citations

Fragments of the internal transcribed spacer 1 of pre-rRNA accumulate in Saccharomyces cerevisiae lacking 5'----3' exoribonuclease 1

1991 • 128 citations

5′-Exonuclease-2 of Saccharomyces cerevisiae

1995 • 118 citations

kem mutations affect nuclear fusion in Saccharomyces cerevisiae.

1990 • 117 citations

Evidence that the SKI antiviral system of Saccharomyces cerevisiae acts by blocking expression of viral mRNA.

1993 • 116 citations

Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities

1991 • 112 citations

An essential yeast gene with homology to the exonuclease-encoding XRN1/KEM1 gene also encodes a protein with exoribonuclease activity.

1993 • 112 citations

Yeast Virus Propagation Depends Critically on Free 60S Ribosomal Subunit Concentration

1995 • 107 citations

mRNA Degradation in Prokaryotic Cells: An Overview

1993 • 105 citations

Molecular and genetic analysis of the gene encoding the Saccharomyces cerevisiae strand exchange protein Sep1.

1991 • 104 citations

Synthetic Lethality of sep1 (xrn1) ski2 and sep1 (xrn1) ski3 Mutants of Saccharomyces cerevisiae Is Independent of Killer Virus and Suggests a General Role for These Genes in Translation Control

1995 • 97 citations

Regulation and Intracellular Localization of Saccharomyces cerevisiae Strand Exchange Protein 1 (Sep1/Xrn1/Kem1), a Multifunctional Exonuclease

1995 • 88 citations

rarmutations which increase artificial chromosome stability inSaccharomyces cerevisiaeidentify transcription and recombination proteins

1991 • 76 citations

The base-alteration spectrum of spontaneous and ultraviolet radiation-induced forward mutations in the URA3 locus of Saccharomyces cerevisiae

1988 • 65 citations

DNA strand transfer protein beta from yeast mitotic cells differs from strand transfer protein alpha from meiotic cells.

1990 • 64 citations

A role of Sep1 (= Kem1, Xrn1) as a microtubule-associated protein in Saccharomyces cerevisiae.

1995 • 62 citations

Rme1, a negative regulator of meiosis, is also a positive activator of G1 cyclin gene expression.

1995 • 61 citations

The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.

1995 • 51 citations

TAP1, a yeast gene that activates the expression of a tRNA gene with a defective internal promoter.

1993 • 36 citations

Molecular analysis of the dhp1 + gene of Schizosaccharomyces pombe: an essential gene that has homology to the DST 2 and RAT 1 genes of Saccharomyces cerevisiae

1994 • 32 citations

Characterization of cDNA encoding mouse homolog of fission yeastdhp1⁺gene: structural and functional conservation

1995 • 32 citations

Comparison of features of the RNase activity of 5'-exonuclease-1 and 5'-exonuclease-2 of Saccharomyces cerevisiae.

1995 • 29 citations

Structure of the yeast TAP1 protein: dependence of transcription activation on the DNA context of the target gene.

1993 • 24 citations

A multifunctional exonuclease from vegetative Schizosaccharomyces pombe cells exhibiting in vitro strand exchange activity.

1994 • 22 citations

Genes controlling conjugation and mitotic cell division in yeast saccharomyces cerevisiae

1988 • 6 citations