The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

Basic local alignment search tool

1990 • 87,358 citations

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1991 • 2,629 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

Hidden Markov models

1996 • 1,313 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

ALSCRIPT: a tool to format multiple sequence alignments

1993 • 1,125 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

An attempt to unify the structure of polymerases

1990 • 640 citations

Amino acid substitution matrices from an information theoretic perspective

1991 • 637 citations

FUNCTION AND STRUCTURE RELATIONSHIPS IN DNA POLYMERASES

1994 • 611 citations

Compilation, alignment, and phylogenetic relationships of DNA polymerases

1993 • 590 citations

Implications for bcd mRNA localization from spatial distribution of exu protein in Drosophila oogenesis

1994 • 482 citations

Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

1993 • 473 citations

Hidden Markov models of biological primary sequence information.

1994 • 465 citations

Hidden Markov models for sequence analysis: extension and analysis of the basic method

1996 • 448 citations

A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

1989 • 433 citations

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

1988 • 405 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Compilation and alignment of DNA polymerase sequences

1991 • 339 citations

Dirichlet mixtures: a method for improved detection of weak but significant protein sequence homology

1996 • 338 citations

A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase

1997 • 335 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Identification of protein sequence homology by consensus template alignment

1986 • 283 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs

1997 • 237 citations

The (QxW)₃ domain: A flexible lectin scaffold

1996 • 199 citations

An Egalitarian-BicaudalD complex is essential for oocyte specification and axis determination in Drosophila.

1997 • 198 citations

Statistical modeling and analysis of the LAGLIDADG family of site- specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family

1997 • 190 citations

Comparative sequence analysis of ribonucleases HII, III, II PH and D

1997 • 183 citations

The Yeast Pan2 Protein Is Required for Poly(A)-binding Protein-stimulated Poly(A)-nuclease Activity

1996 • 182 citations

Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development.

1993 • 172 citations

Using Dirichlet mixture priors to derive hidden Markov models for protein families.

1993 • 170 citations

PAN3 Encodes a Subunit of the Pab1p-Dependent Poly(A) Nuclease in Saccharomyces cerevisiae

1996 • 160 citations

Amino acid sequence motif of group I intron endonucleases is conserved in open reading frames of group II introns

1994 • 146 citations

3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.

1992 • 140 citations

Flexible protein sequence patterns

1990 • 120 citations

Exonucleolytic Proofreading during Replication of Repetitive DNA

1996 • 111 citations

Identification of a Mouse Protein Whose Homolog in Saccharomyces cerevisiae Is a Component of the CCR4 Transcriptional Regulatory Complex

1995 • 109 citations

The tRNA processing enzyme RNase T is essential for maturation of 5S RNA.

1995 • 105 citations

Crystal Structures of an NH₂-Terminal Fragment of T4 DNA Polymerase and Its Complexes with Single-Stranded DNA and with Divalent Metal Ions

1996 • 102 citations

Scoring hidden Markov models

1997 • 89 citations

The role of individual exoribonucleases in processing at the 3' end of Escherichia coli tRNA precursors.

1994 • 85 citations

Statistical Modeling, Phylogenetic Analysis and Structure Prediction of a Protein Splicing Domain Common to Inteins and Hedgehog Proteins

1997 • 74 citations

Multiple exoribonucleases are required for the 3' processing of Escherichia coli tRNA precursors in vivo.

1993 • 72 citations

mRNA Localisation during Development

1995 • 72 citations

Herpes Simplex Virus Type 1 DNA Polymerase

1996 • 68 citations

Members of the immunoglobulin superfamily in bacteria

1996 • 67 citations

Protein encoded by the exuperantia gene is concentrated at sites of bicoid mRNA accumulation in Drosophila nurse cells but not in oocytes or embryos.

1991 • 58 citations

Role of proofreading and mismatch repair in maintaining the stability of nucleotide repeats in DNA

1997 • 56 citations

Evidence that SbcB and RecF pathway functions contribute to RecBCD-dependent transductional recombination

1996 • 49 citations

The 3′–5′ exonuclease site of DNA polymerase III from Gram-positive bacteria: definition of a novel motif structure

1995 • 42 citations

Escherichia colidinG gene encodes a putative DNA helicase related to a group of eukaryotic helicases including Rad3 protein

1993 • 39 citations

Hidden Markov Model Analysis of Motifs in Steroid Dehydrogenases and Their Homologs

1997 • 38 citations

The bacteriophage T4 dexA gene: Sequence and analysis of a gene conditionally required for DNA replication

1987 • 35 citations

Transfer RNA is a substrate for RNase D in vivo.

1988 • 34 citations

RNase T shares conserved sequence motifs with DNA proofreading exonucleases

1993 • 34 citations

Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability

1996 • 34 citations

Structural and functional analysis of temperature-sensitive mutants of the phage phi 29 DNA polymerase.

1990 • 33 citations

Stochastic motif extraction using hidden Markov model.

1994 • 33 citations

The REC1 Gene of Ustilago maydis, Which Encodes a 3′ → 5′ Exonuclease, Couples DNA Repair and Completion of DNA Synthesis to a Mitotic Checkpoint

1996 • 29 citations

A putative new peptide synthase operon in Bacillus subtilis: partial characterization

1995 • 28 citations

Cloning and expression of a Xenopus gene that prevents mitotic catastrophe in fission yeast

1995 • 23 citations

Determination of the nucleotide sequence for the exonuclease I structural gene (sbcB) of Escherichia coli K12.

1987 • 20 citations

Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae

1995 • 20 citations

Components acting in localization of bicoid mRNA are conserved among Drosophila species.

1994 • 19 citations

The Role of Individual Cysteine Residues in the Activity of Escherichia coli RNase T

1996 • 14 citations

Effect of DNA sequence and structure on nuclease activity of the DexA protein of bacteriophage T4

1988 • 7 citations

Deleted Work

1955 • 0 citations