Manipulation of the vsg co-transposed region increases expression-site switching in Trypanosoma brucei

Continuous Cultivation of Trypanosoma brucei Blood Stream Forms in a Medium Containing a Low Concentration of Serum Protein without Feeder Cell Layers

1989 • 982 citations

Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma brucei

1975 • 917 citations

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

1993 • 463 citations

DNA LOOPING

1992 • 408 citations

Coupling of poly(A) site selection and trans-splicing in Leishmania.

1993 • 345 citations

Programmed Gene Rearrangements Altering Gene Expression

1987 • 312 citations

Control of gene expression in trypanosomes

1995 • 291 citations

Cellular and Genetic Aspects of Antigenic Variation in Trypanosomes

1990 • 276 citations

A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes.

1994 • 269 citations

An analysis of cosmid clones of nuclear DNA fromTrypanosoma bruceishows that the genes for variant surface glycoproteins are clustered in the genome

1982 • 246 citations

Antigenic variation in trypansosomes: Secrets surface slowly

1996 • 225 citations

The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. brucei

1987 • 218 citations

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.

1990 • 214 citations

β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei

1993 • 200 citations

Antigenic variation in syringe passaged populations of Trypanosoma (Trypanozoon) brucei. 1. Rationalization of the experimental approach.

1975 • 189 citations

Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei

1985 • 171 citations

A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei

1995 • 145 citations

Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.

1990 • 140 citations

A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei

1995 • 139 citations

The transposition unit of variant surface glycoprotein gene 118 of Trypanosoma brucei

1983 • 138 citations

High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections

1989 • 136 citations

GENETIC CONTROLS FOR THE EXPRESSION OF SURFACE ANTIGENS IN AFRICAN TRYPANOSOMES

1994 • 129 citations

High-efficiency clonal growth of bloodstream- and insect-form Trypanosoma brucei on agarose plates.

1992 • 129 citations

Anatomy of the parp gene promoter of Trypanosoma brucei.

1991 • 117 citations

Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes

1991 • 112 citations

The 5′-limit of transposition and upstream barren region of a trypanosome VSG gene: tandem 76 base-pair repeats flanking (TAA)₉₀

1984 • 104 citations

Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro

1980 • 102 citations

Selective cleavage of variant surface glycoproteins from Trypanosoma brucei

1979 • 101 citations

Modification of telomeric DNA inTrypanosoma brucei;a role in antigenic variation?

1984 • 97 citations

The telomeric GGGTTA repeats of Trypanosoma brucei contain the hypermodified base J in both strands

1996 • 86 citations

DNA Rearrangements Associated with Multiple Consecutive Directed Antigenic Switches in Trypanosoma brucei

1996 • 86 citations

Analysis of antigen switching rates inTrypanosoma brucei

1986 • 80 citations

The inactivation and reactivation of an expression-linked gene copy for a variant surface glycoprotein in Trypanosoma brucei.

1984 • 80 citations

Possible DNA modification in GC dinucleotides ofTrypanosoma bruceitelomeric sequences; relationship with antigen gene transcriptiond

1984 • 78 citations

A monocistronic transcript for a trypanosome variant surface glycoprotein.

1994 • 76 citations

Mechanisms of stage-regulated gene expression in kinetoplastida

1995 • 74 citations

Expression of Two Variant Surface Glycoproteins on Individual African Trypanosomes During Antigen Switching

1985 • 73 citations

Analysis of Trypanosoma brucei vsg expression site switching in vitro

1997 • 70 citations

Trypanosome variable surface glycoproteins: composite genes and order of expression.

1990 • 65 citations

Stable Expression of Mosaic Coats of Variant Surface Glycoproteins in Trypanosoma brucei

1996 • 64 citations

Characterization of VSG gene expression site promoters and promoter-associated DNA rearrangement events.

1991 • 62 citations

Trypanosome variant surface glycoprotein genes expressed early in infection

1985 • 62 citations

Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum

1986 • 62 citations

Stimuli of differentiation regulate RNA elongation in the transcription units for the major stage-specific antigens ofTrypanosoma brucei

1995 • 60 citations

DNA-mediated transformation of bloodstream-formTrypanosoma brucei

1993 • 60 citations

(TAA)_nwithin sequences flanking several intrachromosomal variant surface glycoprotein genes inTrypanosoma brucei

1985 • 58 citations

Antigenic variation inTrypanosoma brucei: a telomeric expression site for variant-specific surface glycoprotein genes with novel features

1991 • 55 citations

Structure and Transcription of a Telomeric Surface Antigen Gene of Trypanosoma brucei

1985 • 48 citations

Two simultaneously active VSG gene transcription units in a single trypanosoma brucei variant

1985 • 45 citations

Metacyclic Variant Surface Glycoprotein Genes of Trypanosoma brucei Subsp. rhodesiense Are Activated In Situ, and Their Expression Is Transcriptionally Regulated

1986 • 43 citations

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes

1990 • 40 citations

A Proposed Mechanism for Promoter-Associated DNA Rearrangement Events at a Variant Surface Glycoprotein Gene Expression Site

1992 • 39 citations

Essential components of the mini-exon gene promoter in the trypanosomatid Leptomonas seymouri

1995 • 35 citations

Control of Antigenic Variation in African Trypanosomas

1993 • 34 citations

Metacyclic variant surface glycoprotein genes of Trypanosoma brucei subsp. rhodesiense are activated in situ, and their expression is transcriptionally regulated.

1986 • 29 citations

Structure of a telomeric expression site for variant specific surface antigens in Trypanosoma brucei

1990 • 28 citations

Neutralization of individual variable antigen types in metacyclic populations of Trypanosoma brucei does not prevent their subsequent expression in mice

1985 • 26 citations

Structure and transcription of a telomeric surface antigen gene of Trypanosoma brucei.

1985 • 24 citations

Expression site-associated genes transcribed independently of variant surface glycoprotein genes in Trypanosoma brucei

1991 • 24 citations

On the role of repeated sequences 5′ to variant surface glycoprotein genes in African trypanosomes

1987 • 21 citations

A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site.

1992 • 21 citations

Mung bean nuclease cleaves preferentially at the boundaries of variant surface glycoprotein gene transpositions in trypanosome DNA.

1986 • 13 citations

Transcripts from the co-transposed segment of variant surface glycoprotein genes are in Trypanosoma brucei polyribosomes

1989 • 12 citations

Variant specific transcripts from the co-transposed segments of variant surface glycoprotein genes in Trypanosoma brucei

1988 • 10 citations

Cited By (0)

Loading...