Structure and Transcription of a Telomeric Surface Antigen Gene of Trypanosoma brucei

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma brucei

1975 • 917 citations

Transcriptional regulation of hemoglobin switching in chicken embryos.

1981 • 800 citations

Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver

1983 • 469 citations

On the surface coat and flagellar adhesion in trypanosomes

1969 • 443 citations

Separation of Trypanosomes from the Blood of Infected Rats and Mice by Anion-exchangers

1968 • 433 citations

The Immunology of Parasitic Infections

1982 • 401 citations

Antigenic variation in trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules

1984 • 368 citations

Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3′ end

1981 • 258 citations

An analysis of cosmid clones of nuclear DNA fromTrypanosoma bruceishows that the genes for variant surface glycoproteins are clustered in the genome

1982 • 246 citations

Growth of chromosome ends in multiplying trypanosomes

1983 • 244 citations

Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5′ end

1982 • 243 citations

Novel expression-linked copies of the genes for variant surface antigens in trypanosomes

1980 • 240 citations

Structure of the growing telomeres of trypanosomes

1984 • 227 citations

Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes

1984 • 193 citations

Identification of a telomeric DNA sequence in Trypanosoma brucei

1984 • 190 citations

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome

1982 • 183 citations

RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes

1982 • 183 citations

Gene conversion as a mechanism for antigenic variation in Trypanosomes

1983 • 167 citations

Chromosome rearrangements in trypanosoma brucei

1984 • 161 citations

Tandem repetition of the 5′ mini-exon of variant surface glycoprotein genes: A multiple promoter for VSG gene transcription?

1983 • 152 citations

Comparison of the genes coding for the common 5′ terminal sequence of messenger RNAs in three trypanosome species

1984 • 150 citations

Discontinuous synthesis of mRNA in trypanosomes.

1984 • 145 citations

Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in Trypanosoma brucei

1983 • 143 citations

Genomic environment of T. brucei VSG genes: presence of a minichromosome

1982 • 143 citations

The transposition unit of variant surface glycoprotein gene 118 of Trypanosoma brucei

1983 • 138 citations

Genomic rearrangements correlated with antigenic variation inTrypanosoma brucei

1979 • 130 citations

Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.

1981 • 127 citations

Sequence homologies near the C-termini of the variable surface glycoproteins of Trypanosoma brucei

1981 • 123 citations

Many trypanosome messenger RNAs share a common 5′ terminal sequence

1984 • 120 citations

Activation of the genes for variant surface glycoproteins 117 and 118 in Trypanosoma brucei

1983 • 113 citations

Repression of glycoprotein synthesis and release of surface coat during transformation of Trypanosoma brucei.

1983 • 113 citations

Two modes of activation of a single surface antigen gene of trypanosoma brucei

1984 • 110 citations

The 5′-limit of transposition and upstream barren region of a trypanosome VSG gene: tandem 76 base-pair repeats flanking (TAA)₉₀

1984 • 104 citations

Modification of telomeric DNA inTrypanosoma brucei;a role in antigenic variation?

1984 • 97 citations

Differential size variations between transcriptionally active and inactive telomeres ofTrypanosoma brucei

1983 • 84 citations

Modifications of a trypanosoma b. brucei antigen gene repertoire by different DNA recombinational mechanisms

1983 • 83 citations

Telomere conversion in trypanosomes

1983 • 81 citations

Possible DNA modification in GC dinucleotides ofTrypanosoma bruceitelomeric sequences; relationship with antigen gene transcriptiond

1984 • 78 citations

DNA rearrangements linked to expression of a predominant surface antigen gene of trypanosomes

1983 • 77 citations

Two variant surface glycoproteins of Trypanosoma brucei have a conserved C-terminus

1981 • 76 citations

Homologous 3′-terminal regions of mRNAs for surface antigens of different antigenic variants of Trypanosoma brucei

1981 • 73 citations

DNA rearrangements and antigenic variation in Trypanosoma equiperdum: multiple expression-linked sites in independent isolates of trypanosomes expressing the same antigen.

1983 • 67 citations

Sequences homologous to variant antigen mRNA spliced leader in Trypanosomatidae which do not undergo antigenic variation

1984 • 66 citations

Two distinct forms of surface antigen gene rearrangement in Trypanosoma brucei

1982 • 57 citations

Complete nucleotide sequence of complementary DNA coding for a variant surface glycoprotein from Trypanosoma brucei

1982 • 56 citations

Rapid evolution of genes coding for variant surface glycoproteins in trypanosomes

1982 • 51 citations

The control of variant surface antigen synthesis in trypanosomes

1983 • 51 citations

Relationship between multiple copies of a T. brucei variable surface glycoprotein gene whose expression is not controlled by duplication

1983 • 49 citations

Gene activation and re-expression of a Trypanosoma brucei variant surface glycoprotein.

1983 • 48 citations

Structure and expression of aTrypanosoma brucei gambiensevariant specific antigen gene

1982 • 47 citations

Use of a cell rupturing pump for the preparation of thymocyte subcellular fractions

1974 • 40 citations

Variant antigen genes of Trypanosoma brucei: genomic alteration of a spliced leader orphon and retention of expression-linked copies during differentiation.

1984 • 26 citations

Purification of nuclei from a flagellate protozoan, Trypanosoma brucei

1982 • 26 citations

An African trypanosome variant surface glycoprotein gene whose expression is not activated by duplication

1983 • 9 citations