Antigenic variation in trypansosomes: Secrets surface slowly

Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma brucei

1975 • 917 citations

Glycosyl-Phosphatidylinositol Moiety That Anchors Trypanosoma brucei Variant Surface Glycoprotein to the Membrane

1988 • 701 citations

Glycolipid Anchoring of Plasma Membrane Proteins

1990 • 539 citations

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

1993 • 463 citations

Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene

1987 • 307 citations

Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

1994 • 267 citations

Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism.

1993 • 237 citations

α-Amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes

1984 • 228 citations

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.

1990 • 214 citations

A structural motif in the variant surface glycoproteins of Trypanosoma brucei

1993 • 211 citations

β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei

1993 • 200 citations

Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei

1985 • 171 citations

On the DNA content and ploidy of trypanosomes

1982 • 169 citations

Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei.

1995 • 163 citations

A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei.

1992 • 153 citations

Stimulating effect of citrate and cis-aconitate on the transformation ofTrypanosoma brucei bloodstream forms to procyclic forms in vitro

1981 • 149 citations

A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei

1995 • 145 citations

Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.

1990 • 140 citations

A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei

1995 • 139 citations

High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections

1989 • 136 citations

Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues

1991 • 132 citations

A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei.

1994 • 123 citations

cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite

1995 • 121 citations

YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-kappa B during acute-phase response.

1994 • 116 citations

Chromosome organization of the protozoan Trypanosoma brucei.

1990 • 114 citations

Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes

1991 • 112 citations

Transient activity assays of the Trypanosoma brucei variant surface glycoprotein gene promoter: control of gene expression at the posttranscriptional level.

1991 • 109 citations

The 3′-terminal region of the mRNAs for VSG and procyclin can confer stage specificity to gene expression in Trypanosoma brucei.

1995 • 105 citations

Trypanosoma brucei: cis-Aconitate and temperature reduction as triggers of synchronous transformation of bloodstream to procyclic trypomastigotes in vitro

1986 • 102 citations

Selective cleavage of variant surface glycoproteins from Trypanosoma brucei

1979 • 101 citations

mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.

1995 • 101 citations

Release of the variant surface glycoprotein during differentiation of bloodstream to procyclic forms of Trypanosoma brucei

1989 • 99 citations

RNA polymerase I can mediate expression of CAT and neo protein-coding genes in Trypanosoma brucei.

1991 • 99 citations

Modification of telomeric DNA inTrypanosoma brucei;a role in antigenic variation?

1984 • 97 citations

VSG gene expression site control in insect form Trypanosoma brucei.

1994 • 96 citations

Efficient production of functional mRNA mediated by RNA polymerase I in Trypanosoma brucei

1991 • 91 citations

RNA turnover in Trypanosoma brucei.

1987 • 89 citations

VSG gene 118 is transcribed from a cotransposed pol I-like promoter

1987 • 82 citations

Analysis of antigen switching rates inTrypanosoma brucei

1986 • 80 citations

Ordered appearance of antigenic variants of African trypanosomes explained in a mathematical model based on a stochastic switch process and immune-selection against putative switch intermediates.

1989 • 79 citations

Improved separation of chromosome-sized DNA fromTrypanosoma brucei, stock 427-60

1989 • 79 citations

Possible DNA modification in GC dinucleotides ofTrypanosoma bruceitelomeric sequences; relationship with antigen gene transcriptiond

1984 • 78 citations

A monocistronic transcript for a trypanosome variant surface glycoprotein.

1994 • 76 citations

Trypanosoma brucei: Posttranscriptional Control of the Variable Surface Glycoprotein Gene Expression Site

1989 • 76 citations

The PARP and VSG genes ofTrypanosoma bruceido not resemble RNA polymerase II transcription units in sensitivity to Sarkosyl in nuclear run-on assays

1992 • 75 citations

Expression of Two Variant Surface Glycoproteins on Individual African Trypanosomes During Antigen Switching

1985 • 73 citations

Abrupt RNA changes precede the first cell division during the differentiation of Trypanosoma brucei bloodstream forms into procyclic forms in vitro

1993 • 72 citations

Trypanosome variable surface glycoproteins: composite genes and order of expression.

1990 • 65 citations

The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.

1991 • 63 citations

Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum

1986 • 62 citations

Characterization of VSG gene expression site promoters and promoter-associated DNA rearrangement events.

1991 • 62 citations

Stimuli of differentiation regulate RNA elongation in the transcription units for the major stage-specific antigens ofTrypanosoma brucei

1995 • 60 citations

A gene from the VSG expression site ofTrypanosoma bruceiencodes a protein with both leucine-rich repeats and a putative zinc finger

1990 • 59 citations

Reverse transcriptase encoded by a retrotransposon from the trypanosomatid Crithidia fasciculata.

1991 • 58 citations

Antigenic variation inTrypanosoma brucei: a telomeric expression site for variant-specific surface glycoprotein genes with novel features

1991 • 55 citations

The procyclin coat of African trypanosomes (or the not-so-naked trypanosome)

1990 • 48 citations

The importance of mosaic genes to trypanosome survival

1993 • 47 citations

Gap junction structures

1985 • 46 citations

Trypanosoma brucei: posttranscriptional control of the variable surface glycoprotein gene expression site.

1989 • 45 citations

Two simultaneously active VSG gene transcription units in a single trypanosoma brucei variant

1985 • 45 citations

Identification of a new expression site-associated gene in the complete 30.5 kb sequence from the AnTat 1.3A variant surface protein gene expression site of Trypanosoma brucei

1993 • 41 citations

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes

1990 • 40 citations

Identification of proteins encoded by variant surface glycoprotein expression site-associated genes in Trypanosoma brucei

1986 • 40 citations

Antigenic variation in clones of Trypanosoma brucei grown in immune-deficient mice

1985 • 40 citations

A Proposed Mechanism for Promoter-Associated DNA Rearrangement Events at a Variant Surface Glycoprotein Gene Expression Site

1992 • 39 citations

A Similar Gene Is Shared by Both the Variant Surface Glycoprotein and Procyclin Gene Transcription Units of Trypanosoma brucei

1991 • 37 citations

Changes in telomere length associated with antigenic variation in Trypanosoma brucei

1988 • 36 citations

Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei

1987 • 35 citations

Locations of the six disulphide bonds in a variant surface glycoprotein (VSG 117) from Trypanosoma brucei

1983 • 34 citations

Duplicative activation mechanisms of two trypanosome telomeric VSG genes with structurally simple 5′ flanks

1990 • 33 citations

A Strand Bias Occurs in Point Mutations Associated with Variant Surface Glycoprotein Gene Conversion in Trypanosoma rhodesiense

1994 • 30 citations

A new VSG expression site-associated gene (ESAG) in the promoter region of Trypanosoma brucei encodes a protein with 10 potential transmembrane domains

1994 • 28 citations

PARP promoter-mediated activation of a VSG expression site promoter in insect formTrypanosoma brucei

1995 • 27 citations

A similar gene is shared by both the variant surface glycoprotein and procyclin gene transcription units of Trypanosoma brucei.

1991 • 24 citations

Expression site-associated genes transcribed independently of variant surface glycoprotein genes in Trypanosoma brucei

1991 • 24 citations

A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site.

1992 • 21 citations

Expression of a Retroposon-Like Sequence Upstream of the Putative Trypanosoma brucei Variant Surface Glycoprotein Gene Expression Site Promoter

1993 • 18 citations

Genomic organization and context of a trypanosome variant surface glycoprotein gene family

1992 • 18 citations

Trypanosoma brucei: Unusual Expression-Site-Associated Gene Homologies in a Metacyclic VSG Gene-Expression Site

1993 • 15 citations

A strand bias occurs in point mutations associated with variant surface glycoprotein gene conversion in Trypanosoma rhodesiense.

1994 • 14 citations

Expression of a retroposon-like sequence upstream of the putative Trypanosoma brucei variant surface glycoprotein gene expression site promoter.

1993 • 11 citations

Sequence divergence among members of a trypanosome variant surface glycoprotein gene family

1992 • 10 citations

A retroposon in the 5′ flank of a Trypanosoma brucei VSG gene lacks insertional terminal repeats

1990 • 10 citations