Variant specific transcripts from the co-transposed segments of variant surface glycoprotein genes in Trypanosoma brucei

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Splicing of Messenger RNA Precursors

1984 • 874 citations

TRANSCRIPTION TERMINATION AND THE REGULATION OF GENE EXPRESSION

1986 • 811 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Evidence for Trans splicing in trypanosomes

1986 • 486 citations

DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMES

1986 • 418 citations

Molecular basis for trypanosome antigenic variation

1982 • 369 citations

Antigenic variation in trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules

1984 • 368 citations

Identification of a novel Y branch structure as an intermediate in trypanosome mRNA processing: Evidence for Trans splicing

1986 • 354 citations

Alternative splicing caused by RNA secondary structure

1985 • 274 citations

An analysis of cosmid clones of nuclear DNA fromTrypanosoma bruceishows that the genes for variant surface glycoproteins are clustered in the genome

1982 • 246 citations

Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5′ end

1982 • 243 citations

Novel expression-linked copies of the genes for variant surface antigens in trypanosomes

1980 • 240 citations

Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes

1984 • 193 citations

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome

1982 • 183 citations

RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes

1982 • 183 citations

Identification of a small rna containing the trypanosome spliced leader: A donor of shared 5′ sequences of trypanosomatid mRNAs?

1984 • 176 citations

Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei

1985 • 171 citations

Trypanosome mRNAs share a common 5′ spliced leader sequence

1984 • 163 citations

Calmodulin genes in trypanosomes are tandemly repeated and produce multiple mRNAs with a common 5' leader sequence.

1985 • 162 citations

Characterization of the DNA duplication-transposition that controls the expression of two genes for variant surface glycoproteins in Trypanosoma brucei

1982 • 154 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

Discontinuous synthesis of mRNA in trypanosomes.

1984 • 145 citations

Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in Trypanosoma brucei

1983 • 143 citations

Genomic environment of T. brucei VSG genes: presence of a minichromosome

1982 • 143 citations

Characterization of the gene for the microbody (glycosomal) triosephosphate isomerase of Trypanosoma brucei.

1986 • 135 citations

Evidence against a scanning model of RNA splicing.

1983 • 122 citations

Molecular biology of trypanosome antigenic variation

1985 • 114 citations

Activation of the genes for variant surface glycoproteins 117 and 118 in Trypanosoma brucei

1983 • 113 citations

Two modes of activation of a single surface antigen gene of trypanosoma brucei

1984 • 110 citations

Apparent generation of a segmented mRNA from two separate tandem gene families inTrypanosoma cruzi

1985 • 106 citations

The 5′-limit of transposition and upstream barren region of a trypanosome VSG gene: tandem 76 base-pair repeats flanking (TAA)₉₀

1984 • 104 citations

The Istar 1 Serodeme of Trypanosoma brucei: Development of a New Serodeme

1984 • 96 citations

Complete nucleotide sequence of an unusual mobile element from trypanosoma brucei

1984 • 92 citations

Telomeric reciprocal recombination as a possible mechanism for antigenic variation in trypanosomes

1985 • 88 citations

A 5' spliced leader is added in trans to both alpha- and beta-tubulin transcripts in Trypanosoma brucei.

1985 • 88 citations

Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei.

1985 • 83 citations

VSG gene 118 is transcribed from a cotransposed pol I-like promoter

1987 • 82 citations

Antigenic variation in African trypanosomes by gene replacement or activation of alternate telomeres

1984 • 81 citations

Two mechanisms of expression of a predominant variant antigen gene of Trypanosoma brucei

1984 • 77 citations

Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum

1986 • 62 citations

(TAA)_nwithin sequences flanking several intrachromosomal variant surface glycoprotein genes inTrypanosoma brucei

1985 • 58 citations

Trypanosoma brucei: a surface antigen mRNA is discontinuously transcribed from two distinct chromosomes.

1985 • 58 citations

Diverse Patterns of Expression of the Cytochrome c Oxidase Subunit I Gene and Unassigned Reading Frames 4 and 5 During the Life Cycle of Trypanosoma brucei

1985 • 56 citations

Structure and Transcription of a Telomeric Surface Antigen Gene of Trypanosoma brucei

1985 • 48 citations

Structure and expression of aTrypanosoma brucei gambiensevariant specific antigen gene

1982 • 47 citations

Metacyclic Variant Surface Glycoprotein Genes of Trypanosoma brucei Subsp. rhodesiense Are Activated In Situ, and Their Expression Is Transcriptionally Regulated

1986 • 43 citations

Genomic organization of Trypanosoma brucei variant antigen gene families in sequential parasitemias

1983 • 35 citations

DNA Rearrangements of the Variable Surface Antigen Genes of the Trypanosomes1

1984 • 28 citations

Transcription of a transposed trypanosome surface antigen gene starts upstream of the transposed segment.

1985 • 28 citations

Expression of a minichromosomal variant surface glycoprotein gene in Trypanosoma brucei

1985 • 26 citations

The two mechanisms for antigenic variation in Trypanosoma brucei are independent processes

1985 • 10 citations