Antigenic variation inTrypanosoma brucei: a telomeric expression site for variant-specific surface glycoprotein genes with novel features

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication.

1979 • 1,136 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma brucei

1975 • 917 citations

On the surface coat and flagellar adhesion in trypanosomes

1969 • 443 citations

Antigenic variation in trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules

1984 • 368 citations

Programmed Gene Rearrangements Altering Gene Expression

1987 • 312 citations

Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene

1987 • 307 citations

Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3′ end

1981 • 258 citations

The genes and transcripts of an antigen gene expression site from T. brucei

1989 • 257 citations

An analysis of cosmid clones of nuclear DNA fromTrypanosoma bruceishows that the genes for variant surface glycoproteins are clustered in the genome

1982 • 246 citations

Novel expression-linked copies of the genes for variant surface antigens in trypanosomes

1980 • 240 citations

α-Amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes

1984 • 228 citations

Structure of the growing telomeres of trypanosomes

1984 • 227 citations

The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. brucei

1987 • 218 citations

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.

1990 • 214 citations

Trypanosoma equiperdum: Etude des variations antigéniques au cours de la trypanosomose experimentale du lapin

1977 • 199 citations

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome

1982 • 183 citations

GENE AND TRANSCRIPTION UNIT MAPPING BY RADIATION EFFECTS

1978 • 172 citations

Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei

1985 • 171 citations

Comparison of the genes coding for the common 5′ terminal sequence of messenger RNAs in three trypanosome species

1984 • 150 citations

Expression of a Bacterial Gene in a Trypanosomatid Protozoan

1989 • 149 citations

Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.

1990 • 140 citations

Transcription of the procyclic acidic repetitive protein genes of Trypanosoma brucei.

1990 • 137 citations

Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei.

1978 • 134 citations

Genomic rearrangements correlated with antigenic variation inTrypanosoma brucei

1979 • 130 citations

Molecular strategies of parasitic invasion

1986 • 122 citations

Chromosome organization of the protozoan Trypanosoma brucei.

1990 • 114 citations

Activation of the genes for variant surface glycoproteins 117 and 118 in Trypanosoma brucei

1983 • 113 citations

An improved technique for the efficient construction of gene libraries by partial filling-in of cohesive ends

1986 • 112 citations

Procyclic acidic repetitive protein (PARP) genes located in an unusually small alpha-amanitin-resistant transcription unit: PARP promoter activity assayed by transient DNA transfection of Trypanosoma brucei.

1990 • 112 citations

Two modes of activation of a single surface antigen gene of trypanosoma brucei

1984 • 110 citations

Transient activity assays of the Trypanosoma brucei variant surface glycoprotein gene promoter: control of gene expression at the posttranscriptional level.

1991 • 109 citations

Modification of telomeric DNA inTrypanosoma brucei;a role in antigenic variation?

1984 • 97 citations

Telomeric reciprocal recombination as a possible mechanism for antigenic variation in trypanosomes

1985 • 88 citations

Putative Genes of a Variant-Specific Antigen Gene Transcription Unit in Trypanosoma brucei

1988 • 87 citations

VSG gene 118 is transcribed from a cotransposed pol I-like promoter

1987 • 82 citations

The inactivation and reactivation of an expression-linked gene copy for a variant surface glycoprotein in Trypanosoma brucei.

1984 • 80 citations

Possible DNA modification in GC dinucleotides ofTrypanosoma bruceitelomeric sequences; relationship with antigen gene transcriptiond

1984 • 78 citations

Characterization of the RNA polymerases of Trypanosoma brucei: trypanosomal mRNAs are composed of transcripts derived from both RNA polymerase II and III.

1989 • 71 citations

Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum

1986 • 62 citations

Mapping of VSG genes on large expression-site chromosomes of Trypanosoma brucei separated by pulsed-field gradient electrophoresis

1986 • 47 citations

Procyclic Acidic Repetitive Protein (PARP) Genes Located in an Unusually Small α-Amanitin-Resistant Transcription Unit: PARP Promoter Activity Assayed by Transient DNA Transfection of Trypanosoma brucei

1990 • 46 citations

The 5′ flanking sequence of a Trypanosoma brucei variable surface glycoprotein gene

1987 • 45 citations

Two simultaneously active VSG gene transcription units in a single trypanosoma brucei variant

1985 • 45 citations

Identification of proteins encoded by variant surface glycoprotein expression site-associated genes in Trypanosoma brucei

1986 • 40 citations

A flagellar pocket membrane fraction from Trypanosoma brucei rhodesiense: immunogold localization and nonvariant immunoprotection

1988 • 39 citations

Parasites: molecular biology, drug and vaccine design

1989 • 38 citations

An expression-site-associated gene family of trypanosomes is expressed in vivo and shows homology to a variant surface glycoprotein gene

1990 • 36 citations

Changes in telomere length associated with antigenic variation in Trypanosoma brucei

1988 • 36 citations

Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei

1987 • 35 citations

Transcription of the Procyclic Acidic Repetitive Protein Genes of Trypanosoma brucei

1990 • 35 citations

Structure of a telomeric expression site for variant specific surface antigens in Trypanosoma brucei

1990 • 28 citations

Transient Activity Assays of the Trypanosoma brucei Variant Surface Glycoprotein Gene Promoter: Control of Gene Expression at the Posttranscriptional Level

1991 • 27 citations

Chromosome Organization of the Protozoan Trypanosoma brucei

1990 • 24 citations

On the role of repeated sequences 5′ to variant surface glycoprotein genes in African trypanosomes

1987 • 21 citations

Stable variant-specific transcripts of the variant cell surface glycoprotein gene 1.8 expression site in Trypanosoma brucei.

1988 • 15 citations

Re-expression of an inactivated variable surface glycoprotein gene in Trypanosoma equiperdum

1984 • 12 citations

Stable Variant-Specific Transcripts of the Variant Cell Surface Glycoprotein Gene 1.8 Expression Site in Trypanosoma brucei

1988 • 6 citations