Diacylglycerol kinase and phosphatidic acid phosphatase—enzymes metabolizing lipid second messengers

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules.

1990 • 509 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.

1992 • 278 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.

1985 • 270 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets

1991 • 193 citations

Diacylglycerol kinase: a key modulator of signal transduction?

1990 • 189 citations

Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly

1990 • 186 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus

1987 • 145 citations

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies.

1983 • 135 citations

A membrane-bound diacylglycerol kinase that selectively phosphorylates arachidonoyl-diacylglycerol. Distinction from cytosolic diacylglycerol kinase and comparison with the membrane-bound enzyme from Escherichia coli.

1988 • 134 citations

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

1991 • 131 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1989 • 123 citations

Mechanism of activation of the vav protooncogene.

1991 • 122 citations

Gene cloning, sequence, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain

1992 • 120 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.

1990 • 110 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

Regulation of diacylglycerol kinase reaction in Swiss 3T3 cells. Increased phosphorylation of endogenous diacylglycerol and decreased phosphorylation of didecanoylglycerol in response to platelet-derived growth factor.

1988 • 89 citations

Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells.

1991 • 85 citations

Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C

1988 • 85 citations

Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes.

1992 • 82 citations

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ε

1993 • 70 citations

Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatization and h.p.l.c. separation

1993 • 58 citations

[55] Characterization and assay of phosphatidate phosphatase

1991 • 57 citations

Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain.

1990 • 57 citations

Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes

1992 • 54 citations

Phosphorylation of diacylglycerol kinase in vitro by protein kinase C

1989 • 53 citations

Distribution of distinct arachidonoyl-specific and non-specific isoenzymes of diacylglycerol kinase in baboon (Papio cynocephalus) tissues

1990 • 51 citations

The regulatory role of EF-hand motifs of pig 80K diacylglycerol kinase as assessed using truncation and deletion mutants

1991 • 51 citations

Phorbol ester-stimulated hydrolysis of phosphatidylcholine and phosphatidylethanolamine by phospholipase D in HeLa cells. Evidence that the basal turnover of phosphoglycerides does not involve phospholipase D.

1991 • 47 citations

Purification and characterization of cytosolic diacylglycerol kinases of human platelets.

1990 • 43 citations

Agonist-induced production of 1,2-diacylglycerol and phosphatidic acid in intact resistance arteries. Evidence that accumulation of diacylglycerol is not a prerequisite for contraction.

1990 • 40 citations

Physical evidence for the presence of two forms of phosphatidate phosphohydrolase in rat liver

1992 • 39 citations

New patterns of diacylglycerol metabolism in intact cells

1993 • 36 citations

[62] 1,2-diacylglycerol : CDPcholine cholinephosphotransferase

1981 • 25 citations

Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH-3T3 and ras-transformed fibroblasts

1990 • 19 citations

Rapid hydrolysis of diacylglycerol formed during phosphatidate phosphatase assay by lipase activities in rat liver cytosol and microsomes

1989 • 14 citations

[18] Diacylglycerol kinase isozymes from brain and lymphoid tissues

1992 • 12 citations

Isolation and characterization of the human diacylglycerol kinase gene

1993 • 12 citations

Abolishment of bradykinin‐induced calcium oscillations in ras‐transformed fibroblasts by the expression of 80 kDa diacylglycerol kinase

1992 • 7 citations

Effect of perturbing diacylglycerol metabolism on cytosolic free Ca²⁺ oscillations induced in single hepatocytes

1992 • 5 citations