Gene Networks Driving Bovine Mammary Protein Synthesis during the Lactation cycle

Growing roles for the mTOR pathway

2005 • 1,526 citations

The mTOR Pathway in the Control of Protein Synthesis

2006 • 722 citations

Gene networks driving bovine milk fat synthesis during the lactation cycle

2008 • 700 citations

Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?

2005 • 643 citations

Hormonal regulation of mammary differentiation and milk secretion.

2002 • 595 citations

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

2007 • 508 citations

Major Advances in Nutrition: Impact on Milk Composition

2006 • 432 citations

Major Advances Associated with the Biosynthesis of Milk

2006 • 397 citations

Transport of Milk Constituents by the Mammary Gland

2000 • 391 citations

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

2008 • 342 citations

The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

2010 • 300 citations

Identification of reference genes for quantitative real-time PCR in the bovine mammary gland during the lactation cycle

2007 • 300 citations

Cloned transgenic cattle produce milk with higher levels of β-casein and κ-casein

2003 • 265 citations

New functions for amino acids: effects on gene transcription and translation

2006 • 261 citations

Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine

2006 • 249 citations

Amino Acid Utilization by Lactating Mammary Gland

1982 • 235 citations

The role of GSK3 in glucose homeostasis and the development of insulin resistance

2007 • 229 citations

Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function

2005 • 224 citations

Growth and body composition of dairy calves fed milk replacers containing different amounts of protein at two feeding rates1

2006 • 222 citations

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

2008 • 215 citations

REGULATION OF CATIONIC AMINO ACID TRANSPORT: The Story of the CAT-1 Transporter

2004 • 208 citations

Expression and Regulation of Glucose Transporters in the Bovine Mammary Gland

2007 • 184 citations

H⁺‐coupled nutrient, micronutrient and drug transporters in the mammalian small intestine

2007 • 181 citations

Current Concepts of Amino Acid and Protein Metabolism in the Mammary Gland of the Lactating Ruminant

1998 • 176 citations

Regulation of protein synthesis in mammary glands of lactating dairy cows by starch and amino acids

2010 • 154 citations

Socs2 and Elf5 Mediate Prolactin-Induced Mammary Gland Development

2006 • 152 citations

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

2010 • 140 citations

Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: Failure of Stat5 activation and functional differentiation in the absence of Elf5

2009 • 138 citations

Gene regulatory networks in lactation: identification of global principles using bioinformatics

2007 • 131 citations

Absorption and Delivery of Nutrients for Milk Protein Synthesis by Portal-Drained Viscera

1994 • 131 citations

Effects of Photoperiod During the Dry Period on Prolactin, Prolactin Receptor, and Milk Production of Dairy Cows

2005 • 125 citations

Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway

2010 • 122 citations

Glucagon, Insulin, Growth Hormone, and Glucose Concentrations in Blood Plasma of Lactating Dairy Cows

1985 • 121 citations

Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland

2008 • 118 citations

DNA-remethylation around a STAT5-binding enhancer in the αS1-casein promoter is associated with abrupt shutdown of αS1-casein synthesis during acute mastitis

2006 • 118 citations

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation

2006 • 100 citations

Nutritional Stimulation of Milk Protein Yield of Cows Is Associated with Changes in Phosphorylation of Mammary Eukaryotic Initiation Factor 2 and Ribosomal S6 Kinase 11–3

2009 • 98 citations

Calcium Secretion into Milk

2005 • 98 citations

A Ca²⁺–calmodulin–eEF2K–eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions

2009 • 97 citations

Environmental Influences on Protein Content and Composition of Bovine Milk

1982 • 94 citations

Amino Acid Transport Systems in Bovine Mammary Tissue

1985 • 93 citations

Leptin, GH, PRL, Insulin and Metabolic Parameters Throughout the Dry Period and Lactation in Dairy Cows

2005 • 82 citations

Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells

2009 • 81 citations

Role of amino acids in translational mechanisms governing milk protein synthesis in murine and ruminant mammary epithelial cells

2006 • 77 citations

Modelling Mammary Metabolism in the Dairy Cow to Predict Milk Constituent Yield, with Emphasis on Amino Acid Metabolism and Milk Protein Production: Model Evaluation

2002 • 74 citations

Insulin and Prolactin Synergistically Stimulate β-Casein Messenger Ribonucleic Acid Translation by Cytoplasmic Polyadenylation

2004 • 67 citations

Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants

2009 • 65 citations

Translational Regulation of Milk Protein Synthesis at Secretory Activation

2007 • 61 citations

EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation

2006 • 60 citations

IGF-1 stimulates protein synthesis by enhanced signaling through mTORC1 in bovine mammary epithelial cells

2009 • 56 citations

Stat5 in the mammary gland: Controlling normal development and cancer

2006 • 54 citations

Effect of Insulin on Yield and Composition of Milk of Dairy Cows

1966 • 53 citations

Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells

2008 • 49 citations

Secretory proteins compete for production in the mammary gland of transgenic mice

1995 • 49 citations

The activity of transcription factor Stat5 responds to prolactin, growth hormone, and IGF-I in rat and bovine mammary explant culture.

2000 • 48 citations

Initiation and elongation steps of mRNA translation are involved in the increase in milk protein yield caused by growth hormone administration during lactation

2009 • 48 citations

Mammary gland membrane transport systems.

1998 • 45 citations

Stat5 phosphorylation status and DNA-binding activity in the bovine and murine mammary glands

2001 • 45 citations

Changes in messenger RNA abundance of amino acid transporters in rat mammary gland during pregnancy, lactation, and weaning

2009 • 40 citations

Mammalian Target of Rapamycin Regulates the Growth of Mammary Epithelial Cells through the Inhibitor of Deoxyribonucleic Acid Binding Id1 and Their Functional Differentiation through Id2

2006 • 38 citations

High Rates of Mammary Tissue Protein Turnover in Lactating Goats Are Energetically Costly

2009 • 38 citations

Endocrine profiles of cows undergoing extended lactation in relation to the control of lactation persistency

2002 • 35 citations

Casein α s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK

2010 • 35 citations

Physiological levels of Stat5 DNA binding activity and protein in bovine mammary gland.

2000 • 34 citations

Abundance and Phosphorylation State of Translation Initiation Factors in Mammary Glands of Lactating and Nonlactating Dairy Cows

2007 • 28 citations

The poly(A) tail length of casein mRNA in the lactating mammary gland changes depending upon the accumulation and removal of milk

2000 • 27 citations

Limiting Amino Acids for Milk Protein Synthesis By Bovine Mammary Cells in Culture

1978 • 26 citations

Effects of an Enhanced Vitamin A Intake During the Dry Period on Retinoids, Lactoferrin, IGF System, Mammary Gland Epithelial Cell Apoptosis, and Subsequent Lactation in Dairy Cows

2005 • 26 citations

Dual Mechanism of Signal Transducer and Activator of Transcription 5 Activation by the Insulin Receptor

2002 • 21 citations

Milk composition studies in transgenic goats expressing recombinant human butyrylcholinesterase in the mammary gland

2008 • 18 citations

The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking

2008 • 15 citations

Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro

2008 • 15 citations

The poly(A) tail length of casein mRNA in the lactating mammary gland changes depending upon the accumulation and removal of milk

2000 • 12 citations

Cloning of Bovine Eukaryotic Translation Initiation Factor 4E (eIF-4E) and Its Expression in the Bovine Mammary Gland at Different Physiological Stages

2001 • 8 citations

Quantitative aspects of protein fractional synthesis rates in ruminants

1997 • 6 citations

Casein Synthesis by Mouse Polysomes and Their Messenger Ribonucleic Acid Extracts

1982 • 2 citations