Role of amino acids in translational mechanisms governing milk protein synthesis in murine and ruminant mammary epithelial cells

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

Transport of Milk Constituents by the Mammary Gland

2000 • 391 citations

Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.

1984 • 336 citations

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1998 • 331 citations

Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation

2001 • 296 citations

Cloned transgenic cattle produce milk with higher levels of β-casein and κ-casein

2003 • 265 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

REGULATION OF MILK PROTEIN GENE EXPRESSION

1999 • 217 citations

mTOR-mediated regulation of translation factors by amino acids

2003 • 212 citations

Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins

2005 • 209 citations

Implication of eIF2B Rather Than eIF4E in the Regulation of Global Protein Synthesis by Amino Acids in L6 Myoblasts

1998 • 166 citations

Control of protein synthesis by amino acid availability

2002 • 130 citations

Intracellular Sensing of Amino Acids in Xenopus laevis Oocytes Stimulates p70 S6 Kinase in a Target of Rapamycin-dependent Manner

2002 • 124 citations

The Role of Insulin in the Regulation of Milk Protein Synthesis in Dairy Cows

1997 • 123 citations

Regulation of Global and Specific mRNA Translation by Amino Acids

2002 • 120 citations

Prolactin Activates Tyrosyl Phosphorylation of Insulin Receptor Substrate 1 and Phosphatidylinositol-3-OH Kinase

1997 • 103 citations

Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats

2001 • 101 citations

Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin

2003 • 99 citations

Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level.

1988 • 83 citations

Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

2004 • 83 citations

Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase

2004 • 81 citations

Expression of human serum albumin in the milk of transgenic mice

1992 • 77 citations

Transcription factor regulation in mammary epithelial cells

2002 • 74 citations

Insulin and Prolactin Synergistically Stimulate β-Casein Messenger Ribonucleic Acid Translation by Cytoplasmic Polyadenylation

2004 • 67 citations

Mitotic Regulation of Ribosomal S6 Kinase 1 Involves Ser/Thr, Pro Phosphorylation of Consensus and Non-consensus Sites by Cdc2

2003 • 66 citations

Transcription factor activities and gene expression during mouse mammary gland involution.

1999 • 62 citations

Essential Role of Insulin in Transcription of the Rat 25,000 Molecular Weight Casein Gene

1984 • 60 citations

CHARACTERIZATION OF AN EPITHELIAL CELL LINE FROM BOVINE MAMMARY GLAND

2002 • 59 citations

Regulatory signals in messenger RNA: determinants of nutrient-gene interaction and metabolic compartmentation

1998 • 55 citations

High expression of the caprine β‐casein gene in transgenic mice

1992 • 55 citations

Transcriptional and post-transcriptional roles of glucocorticoid in the expression of the rat 25,000 molecular weight casein gene

1986 • 54 citations

Transcription inhibitors stimulate translation of 5′ TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway

2000 • 52 citations

Expression analysis of the individual bovine β-,αs2- and κ-casein genes in transgenic mice

1995 • 51 citations

Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle

2004 • 48 citations

Translation Control of Gene Expression

1991 • 42 citations

Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells

2000 • 37 citations

Transcriptional Control of the Cell Cycle in Mammary Gland Development and Tumorigenesis

2004 • 35 citations

24 Control of the Elongation Phase of Protein Synthesis

2000 • 32 citations

The poly(A) tail length of casein mRNA in the lactating mammary gland changes depending upon the accumulation and removal of milk

2000 • 27 citations

Application of a Mechanistic Model to Study Competitive Inhibition of Amino Acid Uptake by the Lactating Bovine Mammary Gland

1998 • 22 citations

In vivo and in vitro expression of human serum albumin genomic sequences in mammary epithelial cells with ?-lactoglobulin and whey acidic protein promoters

1999 • 21 citations

Model of Milk Protein Synthesis. A Mechanistic Model of Milk Protein Synthesis in the Lactating Bovine Mammary Gland

1997 • 19 citations

Prolactin and insulin synergize to regulate the translation modulator PHAS-I via mitogen-activated protein kinase-independent but wortmannin- and rapamycin-sensitive pathway

1999 • 19 citations

Developmental regulation of the ovine β‐lactoglobulin/human serum albumin transgene is distinct from that of the β‐lactoglobulin and the endogenous β‐casein genes in the mammary gland of transgenic mice

1995 • 12 citations

Insulin and prolactin synergize to induce translation of human serum albumin in the mammary gland of transgenic mice.

1997 • 11 citations

c-myc mRNA is Stabilized by Deprivation of Amino Acids in Primary Cultured Rat Hepatocytes.

1995 • 10 citations

Effects of restriction of amino acid supply to the isolated perfused guinea-pig mammary gland

1979 • 7 citations

Application of a Mechanistic Model of Bovine Milk Protein Synthesis to Examine the Use of Isotope Labeling Methods

1998 • 3 citations