Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

2003 • 1,800 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Perturbations of the AKT signaling pathway in human cancer

2005 • 1,300 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

2001 • 950 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

2001 • 921 citations

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

2001 • 908 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

2003 • 708 citations

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

2003 • 554 citations

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

2005 • 540 citations

ATP citrate lyase is an important component of cell growth and transformation

2005 • 506 citations

Akt-dependent transformation: there is more to growth than just surviving

2005 • 430 citations

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP

2005 • 424 citations

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

2005 • 399 citations

The Citrate Cleavage Enzyme

1959 • 391 citations

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

2003 • 375 citations

Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

2002 • 373 citations

The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes

2002 • 354 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

Isoform-specific Regulation of Insulin-dependent Glucose Uptake by Akt/Protein Kinase B

2003 • 308 citations

Role of stearoyl-coenzyme A desaturase in lipid metabolism

2003 • 287 citations

Lipid metabolism in the lactating mammary gland

1997 • 278 citations

Deviant energetic metabolism of glycolytic cancer cells

1992 • 264 citations

Impaired platelet responses to thrombin and collagen in AKT-1–deficient mice

2004 • 234 citations

REGULATION OF MILK PROTEIN GENE EXPRESSION

1999 • 217 citations

Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.

2002 • 205 citations

A novel doxycycline‐inducible system for the transgenic analysis of mammary gland biology

2002 • 201 citations

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

2000 • 184 citations

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

2004 • 177 citations

Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice

2001 • 165 citations

Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation.

1996 • 163 citations

The mitochondrial tricarboxylate transport protein. cDNA cloning, primary structure, and comparison with other mitochondrial transport proteins

1993 • 159 citations

Creation and phenotypic analysis of alpha-lactalbumin-deficient mice.

1994 • 147 citations

Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation

2003 • 139 citations

Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development

2005 • 134 citations

Functional Microarray Analysis of Mammary Organogenesis Reveals a Developmental Role in Adaptive Thermogenesis

2002 • 123 citations

Role of protein kinase B in insulin-regulated glucose uptake

2005 • 120 citations

Biological characterisation of breast cancer by means of PET

2004 • 99 citations

Imaging performance of a-PET: a small animal PET camera

2005 • 96 citations

High and polarized expression of GLUT1 glucose transporters in epithelial cells from mammary gland: acute down-regulation of GLUT1 carriers by weaning.

1994 • 90 citations

Milk composition and lactation of beta-casein-deficient mice.

1994 • 89 citations

Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation

2005 • 88 citations

Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes: contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate.

1999 • 61 citations

Protein Kinase Expression during Murine Mammary Development

2000 • 56 citations

Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions

2003 • 52 citations

Dietary fat regulates mammary stearoyl CoA desaturase expression and activity in lactating mice

2004 • 48 citations

Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland

2000 • 33 citations

Seeking a Home for a PET, Part 3

2004 • 32 citations

Genomic analysis of early murine mammary gland development using novel probe-level algorithms.

2005 • 18 citations

Mouse mammary gland DNA synthesis during pregnancy

1982 • 18 citations