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H+‐coupled nutrient, micronutrient and drug transporters in the mammalian small intestine

Data up to Jan 2025

Published2007
Citations181
References206

Total Citations Per Year

Abstract

References (206)

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Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane

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Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past

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cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1

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Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH

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Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function

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Nramp2 Expression Is Associated with pH-dependent Iron Uptake across the Apical Membrane of Human Intestinal Caco-2 Cells

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Lactose transport coupled to proton movements in escherichia coli

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The sodium bile salt cotransport family SLC10

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Stoicheiometry of lactose–proton symport across the plasma membrane of Escherichia coli

1973 • 244 citations

Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder

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A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells.

1994 • 242 citations

Mammalian peptide transporters as targets for drug delivery

2002 • 239 citations

Conservation of amino acid transporters in fungi, plants and animals

2002 • 230 citations

Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline.

1983 • 230 citations

Identification and characterization of a lysosomal transporter for small neutral amino acids

2001 • 229 citations

Proton-coupled ?-galactoside translocation in non-metabolizingEscherichia coli

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Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2

1990 • 224 citations

Potassium Migration and Amino Acid Transport

1958 • 223 citations

CITRUS JUICES INHIBIT THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B

2005 • 220 citations

Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport <scp>l</scp>‐lactate as well as butyrate

1998 • 218 citations

Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells

2003 • 216 citations

The G185R Mutation Disrupts Function of the Iron Transporter Nramp2

1998 • 215 citations

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

2006 • 209 citations

Interaction of L‐cysteine with a human excitatory amino acid transporter.

1996 • 208 citations

Expression and membrane localization of MCT isoforms along the length of the human intestine

2005 • 206 citations

Iron Imports. II. Iron uptake at the apical membrane in the intestine

2005 • 204 citations

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells

2006 • 193 citations

Copper Transport Protein (Ctr1) Levels in Mice Are Tissue Specific and Dependent on Copper Status

2006 • 193 citations

Is intestinal peptide transport energized by a proton gradient?

1985 • 191 citations

Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, ßlactam antibiotics and ACE-inhibitors

1994 • 189 citations

Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter.

2000 • 188 citations

Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1)

2002 • 186 citations

Participation of a Proton-Cotransporter, MCT1, in the Intestinal Transport of Monocarboxylic Acids

1995 • 177 citations

Effect of ionic environment on intestinal sugar transport

1960 • 175 citations

Fast Removal of Synaptic Glutamate by Postsynaptic Transporters

2000 • 173 citations

Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1

2000 • 169 citations

Surprising Versatility of Na+-Glucose Cotransporters: SLC5

2004 • 166 citations

Molecular Cloning of the Human Placental Folate Transporter

1995 • 165 citations

PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS

2006 • 164 citations

Sodium-dependent ascorbic acid transporter family SLC23

2004 • 164 citations

Functional Characterization of Two Novel Mammalian Electrogenic Proton-dependent Amino Acid Cotransporters

2002 • 164 citations

SLC19: the folate/thiamine transporter family

2004 • 162 citations

The human tumour suppressor gene SLC5A8 expresses a Na+–monocarboxylate cotransporter

2004 • 159 citations

Structure, function and immunolocalization of a proton‐coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco‐2

2003 • 154 citations

Proton-linked sugar transport systems in bacteria

1990 • 154 citations

Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

1995 • 153 citations

Cerebral folate deficiency and leukoencephalopathy caused by a mitochondrial DNA deletion

2005 • 151 citations

Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.

1992 • 150 citations

Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate

2004 • 149 citations

Substrate upregulation of the human small intestinal peptide transporter, hPepT1

1998 • 148 citations

Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum

1975 • 147 citations

Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8

2006 • 147 citations

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

2001 • 145 citations

PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids

2005 • 145 citations

Identification of Mammalian Proline Transporter SIT1 (SLC6A20) with Characteristics of Classical System Imino

2005 • 143 citations

Mechanisms maintaining a low-pH microclimate in the intestine

1985 • 138 citations

Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.

1993 • 136 citations

Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles.

1984 • 136 citations

Cation-Sugar Cotransport in the Melibiose Transport System of Escherichia coli

1978 • 135 citations

Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency

2000 • 134 citations

Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

2003 • 134 citations

The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.

1994 • 132 citations

Human intestinal folate transport: Cloning, expression, and distribution of complementary RNA

1997 • 130 citations

H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat

2004 • 128 citations

Folate transport in isolated brush border membrane vesicles from rat intestine.

1981 • 125 citations

Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)

2005 • 125 citations

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function

1992 • 124 citations

SLC11 family of H + -coupled metal-ion transporters NRAMP1 and DMT1

2004 • 120 citations

Distribution of the SGLT1 Na+glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine

1991 • 118 citations

Luminal Leptin Enhances CD147/MCT-1-mediated Uptake of Butyrate in the Human Intestinal Cell Line Caco2-BBE

2002 • 116 citations

Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells

2002 • 116 citations

Cloning and characterization of a second human NRAMP gene on chromosome 12q13

1995 • 114 citations

H+/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na+/H+ exchanger

2002 • 113 citations

Immunohistochemical and Functional Characterization of pH-dependent Intestinal Absorption of Weak Organic Acids by the Monocarboxylic Acid Transporter MCT1

1999 • 111 citations

cDNA Cloning and Functional Characterization of Rat Intestinal Monocarboxylate Transporter

1995 • 110 citations

The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed—12 06 06

2007 • 110 citations

The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis

2004 • 106 citations

The SLC13 gene family of sodium sulphate/carboxylate cotransporters

2004 • 105 citations

Molecular cloning of the mouse IMINO system: an Na+- and Cl−-dependent proline transporter

2005 • 102 citations

The SLC31 (Ctr) copper transporter family

2004 • 98 citations

Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na + /H + exchange activity

2002 • 96 citations

The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles.

1985 • 92 citations

Folate transport by human intestinal brush-border membrane vesicles

1987 • 91 citations

Molecular genetics of intestinal glucose transport.

1991 • 91 citations

Biological functions of SLC5A8, a candidate tumour suppressor

2005 • 88 citations

Short-chain fatty acid (SCFA) uptake into Caco-2 cells by a pH-dependent and carrier mediated transport mechanism

2000 • 87 citations

H+/solute-induced intracellular acidification leads to selective activation of apical Na+/H+ exchange in human intestinal epithelial cells

1999 • 85 citations

Proton-cotransport of pravastatin across intestinal brush-border membrane.

1995 • 84 citations

H+/Di-tripeptide transporter (PepT1) expression in the rabbit intestine

1995 • 81 citations

Protons drive sugar transport through the Na+/glucose cotransporter (SGLT1).

1994 • 80 citations

H+-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics

1993 • 79 citations

Intestinal folate transport: iventification of a cDNA involved in folate transport and the functional expression and distribution of its mRMA

1996 • 79 citations

Gamma‐aminobutyric acid (GABA) transport across human intestinal epithelial (Caco‐2) cell monolayers

2000 • 77 citations

Na(+)-independent, H(+)-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers.

1993 • 73 citations

Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier

2004 • 72 citations

Uptake of Serotonin at the Apical and Basolateral Membranes of Human Intestinal Epithelial (Caco-2) Cells Occurs through the Neuronal Serotonin Transporter (SERT)

2003 • 72 citations

The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers

1995 • 70 citations

The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo

1988 • 69 citations

EFFECTS OF CATIONS ON SUGAR ABSORPTION BY ISOLATED SURVIVING GUINEA PIG INTESTINE

1958 • 68 citations

Serotonin, <scp>l</scp>‐tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1

2005 • 68 citations

Comparison of intestinal folate carrier clone expressed in IEC-6 cells and inXenopusoocytes

1998 • 67 citations

Neutralization of a Conserved Amino Acid Residue in the Human Na+/Glucose Transporter (hSGLT1) Generates a Glucose-gated H+ Channel

2001 • 64 citations

Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1

2006 • 63 citations

H+‐coupled (Na+‐independent) proline transport in human intestinal (Caco‐2) epithelial cell monolayers

1993 • 63 citations

Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco‐2): identification of substrates that undergo H+‐coupled absorption

1994 • 62 citations

Localization of acid microclimate along intestinal villi of rat jejunum

1985 • 60 citations

Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport.

1990 • 60 citations

The molecular basis of neutral aminoacidurias

2005 • 58 citations

Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1

2003 • 57 citations

Factors affecting the microclimate pH in rat jejunum.

1987 • 56 citations

The Regionalization of PepT1, NBAT and EAAC1 Transporters in the Small Intestine of Rats Are Unchanged from Birth to Adulthood

2002 • 54 citations

Protein Digestion and Absorption

2012 • 53 citations

The Proton/Amino Acid Cotransporter PAT2 Is Expressed in Neurons with a Different Subcellular Localization than Its Paralog PAT1

2004 • 52 citations

Nicotinic Acid Transport Mediated by pH-dependent Anion Antiporter and Proton Cotransporter in Rabbit Intestinal Brush-border Membrane

1996 • 52 citations

Structure, Function and Evolution of Solute Transporters in Prokaryotes and Eukaryotes

1994 • 52 citations

A micro‐electrode study of oligopeptide absorption by the small intestinal epithelium of Necturus maculosus.

1982 • 52 citations

Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach

2005 • 51 citations

Vigabatrin transport across the human intestinal epithelial (Caco‐2) brush‐border membrane is via the H+‐coupled amino‐acid transporter hPAT1

2005 • 49 citations

The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro

1980 • 48 citations

Direct Assessment of Dipeptide/H+ Symport in Intact Human Intestinal (Caco-2) Epithelium: A Novel Method Utilizing Continuous Intracellular pH Measurement

1993 • 47 citations

Characteristics of glutamic acid transport by rabbit intestinal brush-border membrane vesicles. Effects of Na+-, K+-and H+-gradients

1984 • 47 citations

Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine

1990 • 45 citations

A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport

2004 • 45 citations

D‐Cycloserine transport in human intestinal epithelial (Caco‐2) cells: mediation by a H + ‐coupled amino acid transporter

1995 • 44 citations

Different modes of sodium-<scp>d</scp>-glucose cotransporter-mediated<scp>d</scp>-glucose uptake regulation in Caco-2 cells

2004 • 43 citations

L-Alanine absorption in human intestinal Caco-2 cells driven by the proton electrochemical gradient

1994 • 42 citations

A proton gradient, not a sodium gradient, is the driving force for active transport of lactate in rabbit intestinal brush-border membrane vesicles

1988 • 41 citations

Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2

2003 • 41 citations

Transport of Pharmacologically Active Proline Derivatives by the Human Proton-Coupled Amino Acid Transporter hPAT1

2004 • 41 citations

Functional and molecular responses of suckling rat pups and human intestinal Caco-2 cells to copper treatment

2004 • 41 citations

Demonstration and modification of intervillous pH profiles in rat small intestine in vitro

1989 • 39 citations

pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.

1992 • 39 citations

Immunohistochemical localization of Na+-dependent glucose transporter in the rat digestive tract

1995 • 38 citations

Immunohistochemical localization of Na+-dependent glucose transporter in the rat digestive tract

1995 • 37 citations

Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium.

1985 • 37 citations

Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2)

2004 • 36 citations

Na+-dependent elevation of the acidic cell surface pH (microclimate pH) of rat jejunal villus cells induced by cyclic nucleotides and phorbol ester: possible mediators of the regulation of the Na+/H+ antiporter

1988 • 35 citations

Protein Digestion and Absorption

2006 • 33 citations

Substrate specificity and transport mode of the proton‐dependent amino acid transporter mPAT2

2004 • 33 citations

Monocarboxylate Transporter 1 Mediates DL-2-Hydroxy-(4-Methylthio)Butanoic Acid Transport across the Apical Membrane of Caco-2 Cell Monolayers

2007 • 32 citations

Appearance of phloridzin‐sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes

1992 • 32 citations

Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic

1993 • 31 citations

Chemiosmotic concept of the membrane bioenergetics: What is already clear and what is still waiting for elucidation?

1994 • 31 citations

Organization and expression of the SLC36 cluster of amino acid transporter genes

2004 • 30 citations

Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti‐absorptive effect via the VPAC1 receptor in a human enterocyte‐like cell line (Caco‐2)

2003 • 29 citations

Hydrogen ion-coupled transport of d-glucose by phlorizin-sensitive sugar carrier in intestinal brush-border membranes

1986 • 29 citations

H+‐Zwitterionic Amino Acid Symport at the Brush‐Border Membrane of Human Intestinal Epithelial (Caco‐2) Cells

1999 • 29 citations

Indirect regulation of the intestinal H+‐coupled amino acid transporter hPAT1 (SLC36A1)

2005 • 27 citations

H+-coupled α-methylaminoisobutyric acid transport in human intestinal Caco-2 cells

1995 • 25 citations

Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function

2004 • 25 citations

Na+ and pH dependence of proline and β‐alanine absorption in rat small intestine

2006 • 22 citations

Genetic regulation of enterocyte function: a quantitative in situ hybridisation study of lactase-phlorizin hydrolase and Na+-glucose cotransporter mRNAs in rabbit small intestine

1993 • 22 citations

Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2

2004 • 21 citations

Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles

2005 • 19 citations

Transport characteristics of l-glutamate in human jejunal brush-border membrane vesicles

1987 • 16 citations

Effect of Metabolizable Sugars on the Mucosal Surface pH of Rat Intestine

1986 • 16 citations

The H+‐dependent reduced folate carrier 1 of humans and the sodium‐dependent methotrexate carrier‐1 of the rat are orthologs

2004 • 14 citations

Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3)

2007 • 14 citations

The effect of heat-stable escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo

1988 • 14 citations

Naming plan for membrane transport systems for amino acids

1984 • 9 citations

Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2

2005 • 9 citations

The effect of heat-stable Escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo

1988 • 8 citations

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