H+‐coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
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References (206)
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1996 • 208 citations
Expression and membrane localization of MCT isoforms along the length of the human intestine
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Iron Imports. II. Iron uptake at the apical membrane in the intestine
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Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
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Copper Transport Protein (Ctr1) Levels in Mice Are Tissue Specific and Dependent on Copper Status
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Is intestinal peptide transport energized by a proton gradient?
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Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, ßlactam antibiotics and ACE-inhibitors
1994 • 189 citations
Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter.
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Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1)
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Participation of a Proton-Cotransporter, MCT1, in the Intestinal Transport of Monocarboxylic Acids
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Effect of ionic environment on intestinal sugar transport
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Fast Removal of Synaptic Glutamate by Postsynaptic Transporters
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Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1
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Surprising Versatility of Na+-Glucose Cotransporters: SLC5
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Molecular Cloning of the Human Placental Folate Transporter
1995 • 165 citations
PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS
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Sodium-dependent ascorbic acid transporter family SLC23
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Functional Characterization of Two Novel Mammalian Electrogenic Proton-dependent Amino Acid Cotransporters
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SLC19: the folate/thiamine transporter family
2004 • 162 citations
The human tumour suppressor gene SLC5A8 expresses a Na+–monocarboxylate cotransporter
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Structure, function and immunolocalization of a proton‐coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco‐2
2003 • 154 citations
Proton-linked sugar transport systems in bacteria
1990 • 154 citations
Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3
1995 • 153 citations
Cerebral folate deficiency and leukoencephalopathy caused by a mitochondrial DNA deletion
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Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.
1992 • 150 citations
Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate
2004 • 149 citations
Substrate upregulation of the human small intestinal peptide transporter, hPepT1
1998 • 148 citations
Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum
1975 • 147 citations
Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8
2006 • 147 citations
Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis
2001 • 145 citations
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
2005 • 145 citations
Identification of Mammalian Proline Transporter SIT1 (SLC6A20) with Characteristics of Classical System Imino
2005 • 143 citations
Mechanisms maintaining a low-pH microclimate in the intestine
1985 • 138 citations
Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.
1993 • 136 citations
Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles.
1984 • 136 citations
Cation-Sugar Cotransport in the Melibiose Transport System of Escherichia coli
1978 • 135 citations
Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency
2000 • 134 citations
Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery
2003 • 134 citations
The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.
1994 • 132 citations
Human intestinal folate transport: Cloning, expression, and distribution of complementary RNA
1997 • 130 citations
H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat
2004 • 128 citations
Folate transport in isolated brush border membrane vesicles from rat intestine.
1981 • 125 citations
Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)
2005 • 125 citations
cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function
1992 • 124 citations
SLC11 family of H + -coupled metal-ion transporters NRAMP1 and DMT1
2004 • 120 citations
Distribution of the SGLT1 Na+glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine
1991 • 118 citations
Luminal Leptin Enhances CD147/MCT-1-mediated Uptake of Butyrate in the Human Intestinal Cell Line Caco2-BBE
2002 • 116 citations
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells
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Cloning and characterization of a second human NRAMP gene on chromosome 12q13
1995 • 114 citations
H+/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na+/H+ exchanger
2002 • 113 citations
Immunohistochemical and Functional Characterization of pH-dependent Intestinal Absorption of Weak Organic Acids by the Monocarboxylic Acid Transporter MCT1
1999 • 111 citations
cDNA Cloning and Functional Characterization of Rat Intestinal Monocarboxylate Transporter
1995 • 110 citations
The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed—12 06 06
2007 • 110 citations
The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
2004 • 106 citations
The SLC13 gene family of sodium sulphate/carboxylate cotransporters
2004 • 105 citations
Molecular cloning of the mouse IMINO system: an Na+- and Cl−-dependent proline transporter
2005 • 102 citations
The SLC31 (Ctr) copper transporter family
2004 • 98 citations
Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na + /H + exchange activity
2002 • 96 citations
The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles.
1985 • 92 citations
Folate transport by human intestinal brush-border membrane vesicles
1987 • 91 citations
Molecular genetics of intestinal glucose transport.
1991 • 91 citations
Biological functions of SLC5A8, a candidate tumour suppressor
2005 • 88 citations
Short-chain fatty acid (SCFA) uptake into Caco-2 cells by a pH-dependent and carrier mediated transport mechanism
2000 • 87 citations
H+/solute-induced intracellular acidification leads to selective activation of apical Na+/H+ exchange in human intestinal epithelial cells
1999 • 85 citations
Proton-cotransport of pravastatin across intestinal brush-border membrane.
1995 • 84 citations
H+/Di-tripeptide transporter (PepT1) expression in the rabbit intestine
1995 • 81 citations
Protons drive sugar transport through the Na+/glucose cotransporter (SGLT1).
1994 • 80 citations
H+-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics
1993 • 79 citations
Intestinal folate transport: iventification of a cDNA involved in folate transport and the functional expression and distribution of its mRMA
1996 • 79 citations
Gamma‐aminobutyric acid (GABA) transport across human intestinal epithelial (Caco‐2) cell monolayers
2000 • 77 citations
Na(+)-independent, H(+)-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers.
1993 • 73 citations
Characterization of a Folate Transporter in HeLa Cells with a Low pH Optimum and High Affinity for Pemetrexed Distinct from the Reduced Folate Carrier
2004 • 72 citations
Uptake of Serotonin at the Apical and Basolateral Membranes of Human Intestinal Epithelial (Caco-2) Cells Occurs through the Neuronal Serotonin Transporter (SERT)
2003 • 72 citations
The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers
1995 • 70 citations
The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo
1988 • 69 citations
EFFECTS OF CATIONS ON SUGAR ABSORPTION BY ISOLATED SURVIVING GUINEA PIG INTESTINE
1958 • 68 citations
Serotonin, <scp>l</scp>‐tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1
2005 • 68 citations
Comparison of intestinal folate carrier clone expressed in IEC-6 cells and inXenopusoocytes
1998 • 67 citations
Neutralization of a Conserved Amino Acid Residue in the Human Na+/Glucose Transporter (hSGLT1) Generates a Glucose-gated H+ Channel
2001 • 64 citations
Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1
2006 • 63 citations
H+‐coupled (Na+‐independent) proline transport in human intestinal (Caco‐2) epithelial cell monolayers
1993 • 63 citations
Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco‐2): identification of substrates that undergo H+‐coupled absorption
1994 • 62 citations
Localization of acid microclimate along intestinal villi of rat jejunum
1985 • 60 citations
Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport.
1990 • 60 citations
The molecular basis of neutral aminoacidurias
2005 • 58 citations
Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1
2003 • 57 citations
Factors affecting the microclimate pH in rat jejunum.
1987 • 56 citations
The Regionalization of PepT1, NBAT and EAAC1 Transporters in the Small Intestine of Rats Are Unchanged from Birth to Adulthood
2002 • 54 citations
Protein Digestion and Absorption
2012 • 53 citations
The Proton/Amino Acid Cotransporter PAT2 Is Expressed in Neurons with a Different Subcellular Localization than Its Paralog PAT1
2004 • 52 citations
Nicotinic Acid Transport Mediated by pH-dependent Anion Antiporter and Proton Cotransporter in Rabbit Intestinal Brush-border Membrane
1996 • 52 citations
Structure, Function and Evolution of Solute Transporters in Prokaryotes and Eukaryotes
1994 • 52 citations
A micro‐electrode study of oligopeptide absorption by the small intestinal epithelium of Necturus maculosus.
1982 • 52 citations
Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach
2005 • 51 citations
Vigabatrin transport across the human intestinal epithelial (Caco‐2) brush‐border membrane is via the H+‐coupled amino‐acid transporter hPAT1
2005 • 49 citations
The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro
1980 • 48 citations
Direct Assessment of Dipeptide/H+ Symport in Intact Human Intestinal (Caco-2) Epithelium: A Novel Method Utilizing Continuous Intracellular pH Measurement
1993 • 47 citations
Characteristics of glutamic acid transport by rabbit intestinal brush-border membrane vesicles. Effects of Na+-, K+-and H+-gradients
1984 • 47 citations
Carrier affinity as a mechanism for the pH-dependence of folate transport in the small intestine
1990 • 45 citations
A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport
2004 • 45 citations
D‐Cycloserine transport in human intestinal epithelial (Caco‐2) cells: mediation by a H + ‐coupled amino acid transporter
1995 • 44 citations
Different modes of sodium-<scp>d</scp>-glucose cotransporter-mediated<scp>d</scp>-glucose uptake regulation in Caco-2 cells
2004 • 43 citations
L-Alanine absorption in human intestinal Caco-2 cells driven by the proton electrochemical gradient
1994 • 42 citations
A proton gradient, not a sodium gradient, is the driving force for active transport of lactate in rabbit intestinal brush-border membrane vesicles
1988 • 41 citations
Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2
2003 • 41 citations
Transport of Pharmacologically Active Proline Derivatives by the Human Proton-Coupled Amino Acid Transporter hPAT1
2004 • 41 citations
Functional and molecular responses of suckling rat pups and human intestinal Caco-2 cells to copper treatment
2004 • 41 citations
Demonstration and modification of intervillous pH profiles in rat small intestine in vitro
1989 • 39 citations
pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.
1992 • 39 citations
Immunohistochemical localization of Na+-dependent glucose transporter in the rat digestive tract
1995 • 38 citations
Immunohistochemical localization of Na+-dependent glucose transporter in the rat digestive tract
1995 • 37 citations
Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium.
1985 • 37 citations
Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2)
2004 • 36 citations
Na+-dependent elevation of the acidic cell surface pH (microclimate pH) of rat jejunal villus cells induced by cyclic nucleotides and phorbol ester: possible mediators of the regulation of the Na+/H+ antiporter
1988 • 35 citations
Protein Digestion and Absorption
2006 • 33 citations
Substrate specificity and transport mode of the proton‐dependent amino acid transporter mPAT2
2004 • 33 citations
Monocarboxylate Transporter 1 Mediates DL-2-Hydroxy-(4-Methylthio)Butanoic Acid Transport across the Apical Membrane of Caco-2 Cell Monolayers
2007 • 32 citations
Appearance of phloridzin‐sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes
1992 • 32 citations
Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic
1993 • 31 citations
Chemiosmotic concept of the membrane bioenergetics: What is already clear and what is still waiting for elucidation?
1994 • 31 citations
Organization and expression of the SLC36 cluster of amino acid transporter genes
2004 • 30 citations
Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti‐absorptive effect via the VPAC1 receptor in a human enterocyte‐like cell line (Caco‐2)
2003 • 29 citations
Hydrogen ion-coupled transport of d-glucose by phlorizin-sensitive sugar carrier in intestinal brush-border membranes
1986 • 29 citations
H+‐Zwitterionic Amino Acid Symport at the Brush‐Border Membrane of Human Intestinal Epithelial (Caco‐2) Cells
1999 • 29 citations
Indirect regulation of the intestinal H+‐coupled amino acid transporter hPAT1 (SLC36A1)
2005 • 27 citations
H+-coupled α-methylaminoisobutyric acid transport in human intestinal Caco-2 cells
1995 • 25 citations
Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function
2004 • 25 citations
Na+ and pH dependence of proline and β‐alanine absorption in rat small intestine
2006 • 22 citations
Genetic regulation of enterocyte function: a quantitative in situ hybridisation study of lactase-phlorizin hydrolase and Na+-glucose cotransporter mRNAs in rabbit small intestine
1993 • 22 citations
Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2
2004 • 21 citations
Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles
2005 • 19 citations
Transport characteristics of l-glutamate in human jejunal brush-border membrane vesicles
1987 • 16 citations
Effect of Metabolizable Sugars on the Mucosal Surface pH of Rat Intestine
1986 • 16 citations
The H+‐dependent reduced folate carrier 1 of humans and the sodium‐dependent methotrexate carrier‐1 of the rat are orthologs
2004 • 14 citations
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3)
2007 • 14 citations
The effect of heat-stable escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo
1988 • 14 citations
Naming plan for membrane transport systems for amino acids
1984 • 9 citations
Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2
2005 • 9 citations
The effect of heat-stable Escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo
1988 • 8 citations