GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo.

Genomic sequencing.

1984 • 8,343 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformaion of Escherichia coli

1987 • 2,493 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Sequences That Regulate the Divergent GAL1-GAL10 Promoter in Saccharomyces cerevisiae

1984 • 955 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Specific DNA binding of GAL4, a positive regulatory protein of yeast

1985 • 767 citations

The Molecular Biology of the Yeast Saccharomyces (Metabolism and Gene Expression)

1985 • 712 citations

A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor

1985 • 686 citations

A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae

1987 • 676 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Activators and targets

1990 • 582 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assembly

1991 • 497 citations

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

1988 • 488 citations

Evidence for translational regulation of the activator of general amino acid control in yeast.

1984 • 472 citations

Nucleosome loss activates yeast downstream promoters in vivo

1988 • 456 citations

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1990 • 450 citations

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae

1988 • 449 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

Saccharomyces cerevisiae GAL1-GAL10 Divergent Promoter Region: Location and Function of the Upstream Activating Sequence UAS_G

1984 • 395 citations

Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II

1987 • 394 citations

Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II

1991 • 379 citations

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

1991 • 378 citations

The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80

1987 • 349 citations

The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro

1986 • 339 citations

Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

1991 • 330 citations

Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit

1987 • 324 citations

Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors

1990 • 312 citations

Mechanism of action of a yeast activator: Direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions

1988 • 286 citations

Changes in histone gene dosage alter transcription in yeast.

1988 • 275 citations

GAL4 derivatives function alone and synergistically with mammalian activators in vitro

1988 • 274 citations

Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast

1988 • 270 citations

Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID

1990 • 254 citations

SELECTED TOPICS IN CHROMATIN STRUCTURE

1985 • 253 citations

Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes

1991 • 242 citations

A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator.

1990 • 229 citations

Interaction of positive and negative regulatory proteins in the galactose regulon of yeast

1987 • 226 citations

Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.

1988 • 226 citations

Effects of histone H4 depletion on the cell cycle and transcription of Saccharomyces cerevisiae.

1988 • 225 citations

Regulated expression of the GAL4 activator gene in yeast provides a sensitive genetic switch for glucose repression.

1991 • 211 citations

Improvement Of Oligonucleotide-Directed Site-Specific Mutagenesis Using Double-Stranded Plasmid DNA

1984 • 189 citations

Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly

1988 • 186 citations

Use of light for footprinting DNA in vivo

1984 • 181 citations

Roles of TFIID in transcriptional initiation by RNA polymerase II

1991 • 180 citations

Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae.

1990 • 178 citations

The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions.

1988 • 176 citations

An upstream transcription factor, USF (MLTF), facilitates the formation of preinitiation complexes during in vitro chromatin assembly.

1990 • 162 citations

Interaction of GAL4 and GAL80 gene regulatory proteins in vitro.

1987 • 161 citations

Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid.

1992 • 157 citations

A functional role for nucleosomes in the repression of a yeast promoter.

1991 • 156 citations

Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae.

1987 • 141 citations

PrlA (SecY) and PrlG (SecE) interact directly and function sequentially during protein translocation in E. coli

1990 • 129 citations

Photofootprinting in vivo detects transcription-dependent changes in yeast TATA boxes

1987 • 117 citations

In vivo DNA-binding properties of a yeast transcription activator protein.

1987 • 112 citations

Poising chromatin for transcription

1987 • 103 citations

Recombinant yeast TFIID, a general transcription factor, mediates activation by the gene-specific factor USF in a chromatin assembly assay.

1990 • 90 citations

An lmproved method for photofootprinting yeast genesin vivousing Taq polymerase

1989 • 89 citations

Organization of theGAL1–GAL10intergeaic control region chromatin

1984 • 80 citations

Photofootprint of nucleosome core DNA in intact chromatin having different structural states

1988 • 78 citations

Upstream Activation Sequence-Dependent Alteration of Chromatin Structure and Transcription Activation of the Yeast GAL1-GAL10 Genes

1989 • 76 citations

Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo.

1991 • 62 citations

Assembly of RNA polymerase II preinitiation complexes before assembly of nucleosomes allows efficient initiation of transcription on nucleosomal templates.

1988 • 59 citations

Analysis of URSG-mediated glucose repression of the GAL1 promoter of Saccharomyces cerevisiae.

1992 • 48 citations

A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.

1990 • 40 citations

In vivo "photofootprint" changes at sequences between the yeast GAL1 upstream activating sequence and "TATA" element require activated GAL4 protein but not a functional TATA element.

1988 • 25 citations