A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Experiments in molecular genetics

1972 • 28,260 citations

Methods in yeast genetics

1979 • 7,824 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

Complete Nucleotide Sequence of the Escherichia coli Plasmid pBR322

1979 • 1,807 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

1982 • 1,539 citations

The SOS regulatory system of Escherichia coli

1982 • 1,491 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

Specific DNA binding of GAL4, a positive regulatory protein of yeast

1985 • 767 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

1984 • 743 citations

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.

1982 • 575 citations

Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.

1981 • 542 citations

Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

1984 • 501 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

Mechanism of action of the lexA gene product.

1981 • 424 citations

Saccharomyces cerevisiae GAL1-GAL10 Divergent Promoter Region: Location and Function of the Upstream Activating Sequence UAS_G

1984 • 395 citations

Repressor structure and the mechanism of positive control

1983 • 324 citations

Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

1984 • 310 citations

Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization.

1984 • 284 citations

Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon.

1982 • 280 citations

Primary Structure of the Saccharomyces cerevisiae GAL4 Gene

1984 • 276 citations

A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene

1984 • 237 citations

Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG.

1984 • 209 citations

Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box".

1984 • 204 citations

Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.

1983 • 180 citations

Isolation and preliminary characterization of the GAL4 gene, a positive regulator of transcription in yeast.

1982 • 176 citations

The lexA gene product represses its own promoter.

1980 • 167 citations

Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae.

1984 • 166 citations

Primary structure of the Saccharomyces cerevisiae GAL4 gene.

1984 • 142 citations

Regulatory Circuits for Gene Expression: The Metabolism of Galactose and Phosphate

1982 • 141 citations

Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence.

1984 • 137 citations

Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast.

1983 • 101 citations

Large-scale purification, oligomerization equilibria, and specific interaction of the LexA repressor of Escherichia coli

1985 • 97 citations

Mutant lambda phage repressor with a specific defect in its positive control function.

1982 • 93 citations

Deletions within a hinge region of a specific DNA-binding protein.

1985 • 73 citations