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Structural basis of long-term potentiation in single dendritic spines

2004 • 2,331 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

The molecular basis of CaMKII function in synaptic and behavioural memory

2002 • 1,855 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

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Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

1993 • 1,302 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

1998 • 1,263 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1998 • 1,147 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

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The MAPK cascade is required for mammalian associative learning

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Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

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Structure of calmodulin refined at 2.2 Å resolution

1988 • 1,019 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

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Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

Genetic dissection of consolidated memory in Drosophila

1994 • 901 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

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Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

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Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro

1988 • 800 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

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Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory

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Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

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Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

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Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

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Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

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Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

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Interaction with the NMDA receptor locks CaMKII in an active conformation

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Protein Synthesis at Synaptic Sites on Dendrites

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An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

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RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

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Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

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Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase

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CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

1995 • 639 citations

Neuronal Ca²⁺/Calmodulin-Dependent Protein Kinase II: The Role of Structure and Autoregulation in Cellular Function

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Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

1994 • 600 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

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Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

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Expression of Constitutively Active CREB Protein Facilitates the Late Phase of Long-Term Potentiation by Enhancing Synaptic Capture

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Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

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Calcium-induced exposure of a hydrophobic surface on calmodulin

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Disruption of Dendritic Translation of CaMKIIα Impairs Stabilization of Synaptic Plasticity and Memory Consolidation

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A persistent postsynaptic modification mediates long-term potentiation in the hippocampus

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A Model of Synaptic Memory

2001 • 488 citations

Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

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Epac: a new cAMP target and new avenues in cAMP research

2003 • 477 citations

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

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Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

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Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

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Gating of CaMKII by cAMP-Regulated Protein Phosphatase Activity During LTP

1998 • 452 citations

Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism.

1995 • 451 citations

Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses

1996 • 444 citations

Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II

1993 • 437 citations

Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II

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Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.

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A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation

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Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.

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Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.

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PHARMACOLOGICAL REGULATION OF CALMODULIN*

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Phosphorylation of CBP Mediates Transcriptional Activation by Neural Activity and CaM Kinase IV

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The 3′-untranslated region of CaMKIIα is a cis-acting signal for the localization and translation of mRNA in dendrites

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Synaptic Vesicle Mobilization Is Regulated by Distinct Synapsin I Phosphorylation Pathways at Different Frequencies

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The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro

1991 • 311 citations

Action Potential-Dependent Regulation of Gene Expression: Temporal Specificity in Ca²⁺, cAMP-Responsive Element Binding Proteins, and Mitogen-Activated Protein Kinase Signaling

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Tetanic Stimulation Leads to Increased Accumulation of Ca²⁺/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons

1999 • 296 citations

Calcium/calmodulin-dependent protein kinase II and synaptic plasticity

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A Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation Requiring cAMP in the Medial Perforant Pathway of Rat Hippocampal Slices

1996 • 279 citations

A genetic test of the effects of mutations in PKA on mossy fiber ltp and its relation to spatial and contextual learning

1995 • 275 citations

Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain.

1991 • 274 citations

Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: Expression in areas associated with learning and memory

1991 • 269 citations

Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate

1990 • 263 citations

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

1988 • 262 citations

Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP

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Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration

1990 • 226 citations

Purification of a novel calmodulin-binding protein from bovine cerebral cortex membranes

1983 • 225 citations

NMDA Receptor Activation Increases Cyclic AMP in Area CA1 of the Hippocampus via Calcium/Calmodulin Stimulation of Adenylyl Cyclase

1993 • 214 citations

Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

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Long-term potentiation differentially affects two components of synaptic responses in hippocampus.

1988 • 207 citations

RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes

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Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins

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Translational Machinery in Dendrites of Hippocampal Neurons in Culture

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Characterization of protein F1 (47 kDa, 4.5 pI): A kinase C substrate directly related to neural plasticity

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Calmodulin-Regulated Adenylyl Cyclases: Cross-Talk and Plasticity in the Central Nervous System

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Molecular mechanisms of CaMKII activation in neuronal plasticity

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Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum

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Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation

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Spatial and temporal changes in signal transduction pathways during LTP

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Type I Calmodulin‐Sensitive Adenylyl Cyclase Is Neural Specific

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Identification of the protein kinase C phosphorylation site in neuromodulin

1990 • 164 citations

Impaired Cerebellar Long-Term Potentiation in Type I Adenylyl Cyclase Mutant Mice

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Cytoplasmic Polyadenylation Element Binding Protein-Dependent Protein Synthesis Is Regulated by Calcium/Calmodulin-Dependent Protein Kinase II

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Dephosphorylation of Neuromodulin by Calcineurin

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P-57 is a neural specific calmodulin-binding protein.

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Calcium binding to complexes of calmodulin and calmodulin binding proteins

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A brain protein and its effect on the CA2+-and protein modulator-activated cyclic nucleotide phosphodiesterase

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Hippocampal CRE-mediated gene expression is required for contextual memory formation

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The effect of high-frequency electrical stimulation and norepinephrine on cyclic AMP levels in normal versus norepinephrine-depleted rat hippocampal slices

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Distinct Cellular Expression of Calcineurin Aα and Aβ in Rat Brain

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Role of Ca²⁺‐stimulated adenylyl cyclases in LTP and memory formation

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Inhibition of the cAMP Pathway Decreases Early Long-Term Potentiation at CA1 Hippocampal Synapses

2000 • 122 citations

Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates.

1984 • 120 citations

Presynaptic CaMKII Is Necessary for Synaptic Plasticity in Cultured Hippocampal Neurons

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Type 8 Adenylyl Cyclase Is Targeted to Excitatory Synapses and Required for Mossy Fiber Long-Term Potentiation

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Determination of the free-energy coupling for binding of calcium ion and troponin I to calmodulin

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Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.

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A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling

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Removal of Giα1 Constraints on Adenylyl Cyclase in the Hippocampus Enhances LTP and Impairs Memory Formation

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Targeted Disruption of RC3 Reveals a Calmodulin-Based Mechanism for Regulating Metaplasticity in the Hippocampus

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Genetic Approaches to Molecular and Cellular Cognition: A Focus on LTP and Learning and Memory

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Interactions between Neurogranin and Calmodulin in Vivo

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Activity-Dependent Induction of Tonic Calcineurin Activity Mediates a Rapid Developmental Downregulation of NMDA Receptor Currents

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Dephosphorylation of Protein Kinase C Substrates, Neurogranin, Neuromodulin, and MARCKS, by Calcineurin and Protein Phosphatases 1 and 2A

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A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing

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Differential distribution of the mRNA encoding two isoforms of the catalytic subunit of calcineurin in the rat brain

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Inhibition of protein synthesis blocks long-term enhancement of generator potentials produced by one-trial in vivo conditioning in Hermissenda.

1990 • 61 citations

Dual Effect of ATP in the Activation Mechanism of Brain Ca²⁺/Calmodulin-Dependent Protein Kinase II by Ca²⁺/Calmodulin

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Memory impairment during prolonged training in mice given inhibitors of cerebral protein synthesis

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Fluorescence energy transfer analysis of calmodulin.cntdot.peptide complexes

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A point mutant of GAP‐43 induces enhanced short‐term and long‐term hippocampal plasticity

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Long Term Depression in the CA1 Field Is Associated with a Transient Decrease in Pre- and Postsynaptic PKC Substrate Phosphorylation

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Analysis of the Role of Calmodulin Binding and Sequestration in Neuromodulin (GAP-43) Function

1996 • 42 citations

PKC activation rescues LTP from NMDA receptor blockade

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Use of a two-hybrid system to investigate molecular interactions of GAP-43

1996 • 22 citations