Role of Ca²⁺‐stimulated adenylyl cyclases in LTP and memory formation

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

Genetic dissection of consolidated memory in Drosophila

1994 • 901 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Contrasting properties of two forms of long-term potentiation in the hippocampus

1995 • 839 citations

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

1988 • 830 citations

Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons

1990 • 755 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

1997 • 738 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

1994 • 704 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

1994 • 600 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

1996 • 594 citations

Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant

1984 • 589 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists

1986 • 545 citations

The current excitement in long term potentiation

1988 • 538 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

1994 • 501 citations

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

1998 • 495 citations

Memories of NMDA receptors and LTP

1995 • 484 citations

Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

1999 • 482 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses

1996 • 444 citations

Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat

1988 • 426 citations

NMDA application potentiates synaptic transmission in the hippocampus

1988 • 421 citations

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1997 • 414 citations

Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.

1995 • 375 citations

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

1998 • 364 citations

Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.

1994 • 360 citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

1997 • 360 citations

GENE DISCOVERY INDROSOPHILA: New Insights for Learning and Memory

1998 • 344 citations

NMDA-Receptor-Independent Long-Term Potentiation

1992 • 310 citations

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

1996 • 293 citations

N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus.

1991 • 286 citations

Circadian Regulation of cAMP Response Element-mediated Gene Expression in the Suprachiasmatic Nuclei

1999 • 282 citations

A Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation Requiring cAMP in the Medial Perforant Pathway of Rat Hippocampal Slices

1996 • 279 citations

A genetic test of the effects of mutations in PKA on mossy fiber ltp and its relation to spatial and contextual learning

1995 • 275 citations

Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: Expression in areas associated with learning and memory

1991 • 269 citations

Direct Modulation of the Secretory Machinery Underlies PKA-Dependent Synaptic Facilitation in Hippocampal Neurons

1996 • 235 citations

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1997 • 217 citations

NMDA Receptor Activation Increases Cyclic AMP in Area CA1 of the Hippocampus via Calcium/Calmodulin Stimulation of Adenylyl Cyclase

1993 • 214 citations

Multiple and cooperative phosphorylation events regulate the CREM activator function.

1993 • 197 citations

Modulation of Both the Early and the Late Phase of Mossy Fiber LTP by the Activation of β-Adrenergic Receptors

1996 • 197 citations

Hippocampal long-term potentiation: Mechanisms and implications for memory.

1982 • 195 citations

Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation

1998 • 190 citations

Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium-dependent regulatory protein (CDR) by CDR-sepharose affinity chromatography.

1979 • 185 citations

A Million Dollar Question: Does LTP = Memory?

1998 • 183 citations

CRE-Mediated Gene Transcription in Neocortical Neuronal Plasticity during the Developmental Critical Period

1999 • 171 citations

Learning-related synaptic plasticity: LTP and LTD

1991 • 165 citations

Impaired Cerebellar Long-Term Potentiation in Type I Adenylyl Cyclase Mutant Mice

1998 • 161 citations

Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.

1994 • 161 citations

Arousal and the conversion of "short-term" to "long-term" memory.

1968 • 156 citations

Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig.

1995 • 156 citations

Induction of immediate early genes by Ca2+ influx requires cAMP-dependent protein kinase in PC12 cells.

1991 • 155 citations

Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.

1995 • 148 citations

L-type Voltage-sensitive Ca2+ Channel Activation Regulates c-fos Transcription at Multiple Levels

1995 • 146 citations

Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a Hebbian rule

1990 • 145 citations

The effect of high-frequency electrical stimulation and norepinephrine on cyclic AMP levels in normal versus norepinephrine-depleted rat hippocampal slices

1985 • 129 citations

Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.

1966 • 107 citations

Upregulation of cAMP Response Element-Mediated Gene Expression during Experience-Dependent Plasticity in Adult Neocortex

2000 • 95 citations

Genes, synapses, and long-term memory

1997 • 82 citations

Inhibition of protein synthesis blocks long-term enhancement of generator potentials produced by one-trial in vivo conditioning in Hermissenda.

1990 • 61 citations

Developmentally Expressed Ca2+-sensitive Adenylyl Cyclase Activity Is Disrupted in the Brains of Type I Adenylyl Cyclase Mutant Mice

1995 • 60 citations

Memory impairment during prolonged training in mice given inhibitors of cerebral protein synthesis

1973 • 60 citations

Type I adenylyl cyclase functions as a coincidence detector for control of cyclic AMP response element-mediated transcription: synergistic regulation of transcription by Ca2+ and isoproterenol.

1994 • 58 citations

Protein kinases involved in the expression of long-term potentiation

1994 • 53 citations

Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.

1994 • 44 citations

Biochemical correlates of short-term sensitization in Aplysia: temporal analysis of adenylate cyclase stimulation in a perfused-membrane preparation.

1987 • 32 citations

Melatonin instantaneously resets intrinsic circadian rhythmicity in the rat suprachiasmatic nucleus

1996 • 28 citations

Do the calmodulin-stimulated adenylyl cyclases play a role in neuroplasticity?

1995 • 16 citations

Promoter Activity of the Proliferating-Cell Nuclear Antigen Gene Is Associated with Inducible CRE-Binding Proteins in Interleukin 2-Stimulated T Lymphocytes

1994 • 12 citations

Memory

1992 • 12 citations