Genetic links between diet and lifespan: shared mechanisms from yeast to humans

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

2004 • 1,337 citations

The Plasticity of Aging: Insights from Long-Lived Mutants

2005 • 1,319 citations

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

2005 • 1,272 citations

Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

2004 • 1,229 citations

Hypothalamic mTOR Signaling Regulates Food Intake

2006 • 1,217 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Obesity Wars

2004 • 1,119 citations

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

2005 • 1,075 citations

C. Elegans II

1998 • 1,072 citations

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

2002 • 1,051 citations

Influence of TOR kinase on lifespan in C. elegans

2003 • 1,017 citations

Extension of chronological life span in yeast by decreased TOR pathway signaling

2006 • 939 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Molecular Biology of Aging

1999 • 877 citations

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

2006 • 856 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

2003 • 782 citations

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

2005 • 774 citations

Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span

1977 • 772 citations

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

2003 • 706 citations

Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans

1991 • 691 citations

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

2003 • 688 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Two neurons mediate diet-restriction-induced longevity in C. elegans

2007 • 638 citations

Calorie restriction extends yeast life span by lowering the level of NADH

2004 • 629 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

Sirtuins in Aging and Age-Related Disease

2006 • 613 citations

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

2004 • 610 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1999 • 554 citations

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

2007 • 534 citations

Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion

1999 • 465 citations

Hypothalamic sensing of fatty acids

2005 • 461 citations

How does calorie restriction work?

2003 • 459 citations

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

2003 • 458 citations

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems

2005 • 453 citations

Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

2005 • 452 citations

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

2006 • 436 citations

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

2004 • 434 citations

Central insulin action in energy and glucose homeostasis

2006 • 429 citations

Increase in Activity During Calorie Restriction Requires Sirt1

2005 • 426 citations

Extending the lifespan of long-lived mice

2001 • 425 citations

Control of Larval Development by Chemosensory Neurons in Caenorhabditis elegans

1991 • 400 citations

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

2005 • 399 citations

Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors

2007 • 388 citations

Sir2 Blocks Extreme Life-Span Extension

2005 • 380 citations

Neuronal Glucosensing

2004 • 374 citations

Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span

2006 • 373 citations

Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons

2004 • 372 citations

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

2004 • 370 citations

Dietary restriction in Drosophila

2005 • 350 citations

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express K_ATPChannels

2003 • 341 citations

Lifespan extension in Caenorhabditis elegans by complete removal of food

2006 • 325 citations

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

2006 • 311 citations

Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease

2005 • 306 citations

Dietary Restriction in Long-Lived Dwarf Flies

2002 • 292 citations

Dietary deprivation extends lifespan in Caenorhabditis elegans

2006 • 281 citations

A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2

2007 • 279 citations

ON THE INFLUENCE OF FOOD AND TEMPERATURE UPON THE DURATION OF LIFE

1917 • 268 citations

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO

2005 • 260 citations

Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans

2003 • 243 citations

HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction

2005 • 228 citations

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans

2002 • 201 citations

Aging networks in Caenorhabditis elegans: AMP‐activated protein kinase (aak‐2) links multiple aging and metabolism pathways

2006 • 196 citations

Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y

1999 • 195 citations

Effects of food restriction on aging: separation of food intake and adiposity.

1984 • 191 citations

Sex-Dependent Metabolic, Neuroendocrine, and Cognitive Responses to Dietary Energy Restriction and Excess

2007 • 187 citations

Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast

2005 • 187 citations

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly

2005 • 178 citations

Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae

2000 • 165 citations

No reduction of metabolic rate in food restricted Caenorhabditis elegans

2002 • 129 citations

Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeast

2006 • 111 citations

Metabolic Pathways That Mediate Inhibition of Hypothalamic Neurons by Glucose

2004 • 96 citations

Neuroendocrine and Pharmacological Manipulations to Assess How Caloric Restriction Increases Life Span

2001 • 80 citations

Interpreting interactions between treatments that slow aging

2002 • 76 citations

Dietary Restriction in Aging Nonhuman Primates

2006 • 69 citations

Genome-wide identification of conserved longevity genes in yeast and worms

2006 • 61 citations

The Dihydrolipoamide Acetyltransferase Is a Novel Metabolic Longevity Factor and Is Required for Calorie Restriction-mediated Life Span Extension

2007 • 54 citations

Diet Restriction in Drosophila melanogaster

2006 • 51 citations

SIR2 and aging – the exception that proves the rule

2001 • 50 citations

Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging

2005 • 49 citations

Secrets of the lac Operon

2006 • 34 citations

Can Short-Term Dietary Restriction and Fasting Have a Long-Term Anticarcinogenic Effect?

2006 • 22 citations