The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Automated MAD and MIR structure solution

1999 • 3,079 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

1997 • 1,592 citations

Dali: a network tool for protein structure comparison

1995 • 1,447 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

1999 • 908 citations

ANTIBODY-ANTIGEN COMPLEXES

1990 • 853 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

RIBBONS 2.0

1991 • 814 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

Protein–protein interactions define specificity in signal transduction

2000 • 757 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Interactions of protein antigens with antibodies.

1996 • 543 citations

Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding

1999 • 500 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1999 • 425 citations

The FHA domain

2001 • 423 citations

The FHA Domain Is a Modular Phosphopeptide Recognition Motif

1999 • 395 citations

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

1998 • 392 citations

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

1998 • 386 citations

Positional cloning of the gene for Nijmegen breakage syndrome

1998 • 336 citations

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

2000 • 291 citations

Cell cycle checkpoints

1994 • 284 citations

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

1998 • 274 citations

[14] Automated refinement for protein crystallography

1997 • 269 citations

Sensing and responding to DNA damage

2000 • 264 citations

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1992 • 255 citations

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

1995 • 253 citations

MEC1-Dependent Phosphorylation of Rad9p in Response to DNA Damage

1998 • 213 citations

RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

1998 • 153 citations

Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain

1999 • 115 citations

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of rad53

1999 • 114 citations

c-Jun is phosphorylated by the DNA-dependent protein kinasein vitro; definition of the minimal kinase recognition motif

1993 • 104 citations

Role of Human Cds1 (Chk2) Kinase in DNA Damage Checkpoint and Its Regulation by p53

1999 • 101 citations

Grabbing phosphoproteins

1999 • 74 citations

The Schizosaccharomyces pombe S-Phase Checkpoint Differentiates Between Different Types of DNA Damage

1998 • 67 citations

DNA repair: The Nijmegen breakage syndrome protein

1998 • 61 citations

FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases

2000 • 36 citations

ATM and Lymphoid Malignancies; Use of Oriented Peptide Libraries to Identify Novel Substrates of ATM Critical in Downstream Signaling Pathways

1999 • 4 citations