Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1993 • 26,634 citations

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

1977 • 19,896 citations

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Quantum and statistical mechanical studies of liquids. 10. Transferable intermolecular potential functions for water, alcohols, and ethers. Application to liquid water

1981 • 1,210 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Molecular dynamics simulations in biology

1990 • 1,033 citations

Application of the multimolecule and multiconformational RESP methodology to biopolymers: Charge derivation for DNA, RNA, and proteins

1995 • 995 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

1999 • 428 citations

Structures of Src-family tyrosine kinases

1997 • 377 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1994 • 247 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

1993 • 208 citations

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

1997 • 201 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

DNA-induced α-helix capping in conserved linker sequences is a determinant of binding affinity in Cys2-His2 zinc fingers

2000 • 148 citations

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src

1997 • 144 citations

Reciprocal Regulation of Hck Activity by Phosphorylation of Tyr527 and Tyr416

2000 • 113 citations

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

2000 • 104 citations

Intramolecular Regulatory Interactions in the Src Family Kinase Hck Probed by Mutagenesis of a Conserved Tryptophan Residue

1998 • 102 citations

Crystal Structures of the Human p56lckSH2 Domain in Complex with Two Short Phosphotyrosyl Peptides at 1.0 Å and 1.8 Å Resolution

1996 • 101 citations

The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases

2001 • 88 citations

Calorimetric Investigation of Proton Linkage by Monitoring both the Enthalpy and Association Constant of Binding: Application to the Interaction of the Src SH2 Domain with a High-Affinity Tyrosyl Phosphopeptide

1998 • 82 citations

Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

2001 • 53 citations

Molecular Determinants for Csk-Catalyzed Tyrosine Phosphorylation of the Src Tail

2001 • 51 citations

Structural differences between repressed and derepressed forms of p60c-src.

1989 • 49 citations

Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3 + 2) construct: the role of protein dynamics in functional regulation

1999 • 42 citations

Methodological advances in molecular dynamics simulations of biological systems

1995 • 41 citations

A method to explore transition paths in macromolecules. Applications to hemoglobin and phosphoglycerate kinase

1995 • 38 citations