A Nuclear Antagonistic Mechanism of Inhibitory Smads in Transforming Growth Factor-β Signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Signaling of transforming growth factor‐β family members through Smad proteins

2000 • 530 citations

Signal transduction by bone morphogenetic proteins

1998 • 528 citations

Smads as transcriptional co-modulators

2000 • 522 citations

A role for Smad6 in development and homeostasis of the cardiovascular system

2000 • 488 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Histone deacetylases: silencers for hire

2000 • 429 citations

Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

1999 • 419 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA

2000 • 397 citations

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

1995 • 396 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA

1999 • 318 citations

Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation

2000 • 303 citations

TGF-β signalling through the Smad pathway

1997 • 265 citations

Transcriptional Coregulators in Development

1999 • 242 citations

Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

1998 • 240 citations

Cloning and characterization of a histone deacetylase, HDAC9

2001 • 234 citations

Co‐repressors 2000

2000 • 201 citations

Smad1 Interacts with Homeobox DNA-binding Proteins in Bone Morphogenetic Protein Signaling

1999 • 187 citations

Induction of Smad6 mRNA by Bone Morphogenetic Proteins

1998 • 168 citations

Smad6 as a Transcriptional Corepressor

2000 • 152 citations

Localization of Smads, the TGF-β Family Intracellular Signaling Components During Endochondral Ossification

1999 • 146 citations

Smad7 inhibits the survival nuclear factor κB and potentiates apoptosis in epithelial cells

2001 • 110 citations

Smad1 Domains Interacting with Hoxc-8 Induce Osteoblast Differentiation

2000 • 109 citations

Transcriptional Mechanisms of Bone Morphogenetic Protein-induced Osteoprotegrin Gene Expression

2001 • 106 citations

Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx.

1996 • 106 citations

The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins.

1995 • 104 citations

Evidence for a Role of Smad6 in Chick Cardiac Development

1999 • 81 citations

Smad6 functions as an intracellular antagonist of some TGF‐β family members during Xenopus embryogenesis

1998 • 78 citations

Smad7 and Smad6 Differentially Modulate Transforming Growth Factor β-induced Inhibition of Embryonic Lung Morphogenesis

2000 • 77 citations

Activation of Smad1-mediated transcription by p300/CBP

1999 • 58 citations

Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling

2001 • 51 citations

Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7

2001 • 34 citations

Competition for a Unique Response Element Mediates Retinoic Acid Inhibition of Vitamin D3-stimulated Transcription

1996 • 25 citations

Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis

2000 • 22 citations