Activation of Smad1-mediated transcription by p300/CBP

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1995 • 1,197 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

RNA Helicase A Mediates Association of CBP with RNA Polymerase II

1997 • 532 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

1996 • 453 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Physical and Functional Interaction of SMADs and p300/CBP

1998 • 351 citations

Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein–Taybi syndrome

1997 • 289 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

1996 • 275 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

1997 • 260 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

Differential Use of CREB Binding Protein-Coactivator Complexes

1998 • 218 citations

Characterization of the Transcriptional Regulator YY1

1997 • 202 citations

Mads and Smads in TGFβ signalling

1998 • 194 citations

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells

1998 • 179 citations

Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins

1996 • 162 citations

Role of p300, a transcriptional coactivator, in signalling of TGF‐β

1998 • 162 citations

Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases

1998 • 144 citations

Elk-1 protein domains required for direct and SRF-assisted DNA-binding

1992 • 137 citations

Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP.

1996 • 120 citations

Regulatory squelching

1994 • 65 citations

Transcriptional activity and constitutive nuclear localization of the ETS protein Elf‐1

1997 • 28 citations