Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

1986 • 1,439 citations

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Cloning of GMP-140, a granule membrane protein of platelets and endothelium: Sequence similarity to proteins involved in cell adhesion and inflammation

1989 • 799 citations

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo.

1995 • 597 citations

Recurrent Severe Infections Caused by a Novel Leukocyte Adhesion Deficiency

1992 • 555 citations

Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins

1996 • 534 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites.

1995 • 450 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.

1989 • 413 citations

Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.

1991 • 406 citations

Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.

1996 • 391 citations

Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.

1994 • 391 citations

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins

1994 • 384 citations

Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha.

1992 • 383 citations

Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1.

1991 • 359 citations

Threshold Levels of Fluid Shear Promote Leukocyte Adhesion through Selectins (CD62L,P,E)

1997 • 349 citations

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.

1991 • 347 citations

Distinct Phenotype of E-Selectin–Deficient Mice

1996 • 338 citations

Heterogeneity of Expression of E- and P-Selectins In Vivo

1996 • 312 citations

P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow.

1995 • 223 citations

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.

1996 • 212 citations

Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells.

1993 • 201 citations

In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes.

1993 • 199 citations

Adhesion and signaling in vascular cell--cell interactions.

1996 • 183 citations

Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells.

1994 • 179 citations

Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.

1990 • 160 citations

Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.

1992 • 154 citations

Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice.

1995 • 146 citations

Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.

1996 • 143 citations

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.

1995 • 127 citations

Blood cell dynamics in P-selectin-deficient mice

1995 • 119 citations

The Association between α4-Integrin, P-Selectin, and E-Selectin in an Allergic Model of Inflammation

1997 • 114 citations

Characterization of a human homologue of the murine peripheral lymph node homing receptor.

1989 • 102 citations

E-selectin mediates leukocyte rolling in interleukin-1-treated rabbit mesentery venules

1994 • 98 citations

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes

1995 • 95 citations

TNF-alpha induces selectin-mediated leukocyte rolling in mouse cremaster muscle arterioles

1997 • 75 citations

Activation‐Dependent Isolation and Culture of Murine Pulmonary Microvascular Endothelium

1995 • 67 citations

Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin

1995 • 58 citations

Murine endothelial leukocyte‐adhesion molecule 1 is a close structral and functional homologue of the human protein

1992 • 55 citations

Characterization of Murine E-Selectin Expression in Vitro Using Novel Anti-mouse E-Selectin Monoclonal Antibodies

1993 • 52 citations

Leukocyte rolling: a prominent feature of venules in intact skin of anesthetized hairless mice

1992 • 49 citations

Spontaneous leukocyte rolling in venules in untraumatized skin of conscious and anesthetized animals

1994 • 48 citations

Microcirculatory Models of Ischaemia-Reperf usion in Skin and Striated Muscle

1995 • 41 citations

Novel Roles for E‐Selectin in Endothelial‐Leukocyte Adhesion^a

1997 • 26 citations

The Selectins and Their Ligands

1993 • 22 citations

Nitric Oxide Mediates Vasoactive Effects of Endothelin-3 on Rat Mesenteric Microvascular Beds in Vivo

1993 • 7 citations