Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.

Textbook of Medical Physiology

1966 • 10,259 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

LSODE and LSODI, two new initial value ordinary differential equation solvers

1980 • 908 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Radiolabeled-Antibody Therapy of B-Cell Lymphoma with Autologous Bone Marrow Support

1993 • 665 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1983 • 560 citations

Investigations of avidin and biotin for imaging applications.

1987 • 405 citations

Animal scale-up

1973 • 389 citations

Transport of fluid and macromolecules in tumors

1991 • 362 citations

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics

1990 • 345 citations

Redesigning Nature's Poisons to Create Anti-Tumor Reagents

1987 • 329 citations

Extravascular diffusion in normal and neoplastic tissues.

1984 • 294 citations

Immunotoxins: A New Approach to Cancer Therapy

1983 • 282 citations

Antibody directed enzymes revive anti-cancer prodrugs concept

1987 • 280 citations

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

1994 • 272 citations

Interstitial hypertension in human breast and colorectal tumors.

1992 • 251 citations

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

1992 • 246 citations

Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients.

1991 • 244 citations

Interstitial hypertension in superficial metastatic melanomas in humans.

1991 • 217 citations

Immunotoxins: magic bullets or misguided missiles?

1993 • 209 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins.

1991 • 188 citations

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.

1991 • 178 citations

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.

1990 • 108 citations

Carcinoembryonic antigen production, secretion, and kinetics in BALB/c mice and a nude mouse-human tumor model.

1984 • 79 citations

Immunotoxins: redirecting nature's poisons

1985 • 78 citations

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

1992 • 70 citations

Physiologically based pharmacokinetic models for anticancer drugs

1979 • 64 citations

A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer

1991 • 55 citations

A distributed pharmacokinetic model of two-step imaging and treatment protocols: application to streptavidin-conjugated monoclonal antibodies and radiolabeled biotin.

1993 • 46 citations

Radioimmunodetection of occult carcinoembryonic antigen-producing cancer.

1992 • 30 citations

Estimation of permanence time, exit time, dilution factor, and steady-state volume of distribution.

1992 • 29 citations

Uptake of radiolabeled anti-CEA antibodies in human colorectal primary tumors as a function of tumor mass

1993 • 18 citations

Activation of Prodrugs by Antibody-Enzyme Conjugates

1991 • 14 citations

Localization of biotinylated monoclonal antibodies (B72.3 and F023C5) in patients with colorectal cancer.

1993 • 5 citations