Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue

1919 • 1,388 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Tumor Angiogenesis

1985 • 1,038 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

1989 • 836 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

1988 • 526 citations

Longitudinal Gradients in Periarteriolar Oxygen Tension

1970 • 460 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

1991 • 349 citations

Oxygen diffusion and the distribution of cellular radiosensitivity in tumours

1972 • 267 citations

Hypoxia in Tumors: A Paradigm for the Approach to Biochemical and Physiologic Heterogeneity

1988 • 246 citations

Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy

1960 • 222 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Analysis of oxygen transport to tumor tissue by microvascular networks

1993 • 199 citations

Radiolabeled fluoromisonidazole as an imaging agent for tumor hypoxia

1989 • 194 citations

Hypoxia in neoplastic tissue

1977 • 176 citations

Drug Resistance in Oncology

1994 • 173 citations

Drug Resistance in Oncology

1997 • 160 citations

Microvessel PO2 measurements by phosphorescence decay method

1993 • 148 citations

The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography

1992 • 134 citations

Effect of hyperventilation on oxygenation of the brain cortex of newborn piglets

1991 • 134 citations

Oxygen supply to tissues: The Krogh model and its assumptions

1982 • 128 citations

Measurement of tumor hypoxia by invasive and non-invasive procedures: a review of recent clinical studies

1991 • 124 citations

Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue

1988 • 119 citations

Measurements of the perivascular PO2 in the vicinity of the pial vessels of the cat

1979 • 113 citations

Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

1992 • 103 citations

Development of the vascular system in the hamster malignant neurilemmoma

1973 • 101 citations

Evaluation of oxygen diffusion distances in human breast cancer xenografts using tumor-specific in vivo data: Role of various mechanisms in the development of tumor hypoxia

1988 • 96 citations

Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging.

1992 • 92 citations

Measurements of pertinent concentrations of oxygen in vivo

1991 • 92 citations

Changes in Microvascular Diameter and Oxygen Tension Induced by Carbon Dioxide

1973 • 57 citations

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.

1993 • 54 citations

Mathematical modelling of oxygen supply and oxygenation in tumor tissues: Prognostic, therapeutic, and experimental implications

1988 • 44 citations

Oxygen Tension in Human Malignant Disease under Hyperbaric Conditions

1965 • 38 citations

Evaluation of a Fluorinated 2-Nitroimidazole Binding to Hypoxic Cells in Tumor-Bearing Rats by 19 F Magnetic Resonance Spectroscopy and Immunohistochemistry

1992 • 27 citations

Effect of convection in capillaries on oxygen removal from arterioles in striated muscle

1990 • 10 citations