Jak2/Stat5 Signaling in Mammogenesis, Breast Cancer Initiation and Progression

The Hallmarks of Cancer

2000 • 27,569 citations

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

2005 • 3,482 citations

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

2005 • 3,358 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

A Road Map for Those Who Don't Know JAK-STAT

2002 • 1,292 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Signaling through the JAK/STAT pathway, recent advances and future challenges

2002 • 1,132 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

1997 • 797 citations

An Atlas of Subgross Pathology of the Human Breast With Special Reference to Possible Precancerous Lesions<xref ref-type="fn" rid="fn2">2</xref>

1975 • 761 citations

The Stat family in cytokine signaling

2001 • 723 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

1997 • 647 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Growth Hormone Insensitivity Associated with aSTAT5bMutation

2003 • 506 citations

Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

2004 • 491 citations

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

1997 • 371 citations

Activation of receptor-associated tyrosine kinase JAK2 by prolactin.

1994 • 354 citations

Prolactin Controls Mammary Gland Development via Direct and Indirect Mechanisms

1999 • 333 citations

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

2001 • 268 citations

An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal

2002 • 264 citations

The Signal Transducer and Activator of Transcription STAT5b Gene Is a New Partner of Retinoic Acid Receptor in Acute Promyelocytic-Like Leukaemia

1999 • 263 citations

Impaired Alveologenesis and Maintenance of Secretory Mammary Epithelial Cells in Jak2 Conditional Knockout Mice

2004 • 239 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

2001 • 232 citations

Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation

1999 • 231 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

1996 • 228 citations

Signal Transducer and Activator of Transcription-5 Activation and Breast Cancer Prognosis

2004 • 221 citations

Spontaneous Lesions in Aging FVB/N Mice

1996 • 214 citations

Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G₂/M Phase, and Protection from Apoptosis

2002 • 210 citations

Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells

2004 • 196 citations

Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation

1999 • 192 citations

Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression

2004 • 191 citations

Antiapoptotic activity ofStat5required during terminal stages of myeloid differentiation

2000 • 188 citations

The JAK2 V617F mutation in de novo acute myelogenous leukemias

2005 • 176 citations

Prolactin Signaling in Mammary Gland Development

1997 • 174 citations

IGF-2 Is a Mediator of Prolactin-Induced Morphogenesis in the Breast

2002 • 168 citations

Caveolin-1 inhibits breast cancer growth and metastasis

2004 • 162 citations

PRL Activates the Cyclin D1 Promoter Via the Jak2/Stat Pathway

2002 • 160 citations

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5

2002 • 153 citations

Severe Growth Hormone Insensitivity Resulting from Total Absence of Signal Transducer and Activator of Transcription 5b

2005 • 145 citations

Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors

1994 • 144 citations

Loss of Caveolin-1 Gene Expression Accelerates the Development of Dysplastic Mammary Lesions in Tumor-Prone Transgenic Mice

2003 • 143 citations

Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers

2003 • 136 citations

Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice

2004 • 125 citations

The Genes Induced by Signal Transducer and Activators of Transcription (STAT)3 and STAT5 in Mammary Epithelial Cells Define the Roles of these STATs in Mammary Development

2005 • 125 citations

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.

2002 • 117 citations

Defining the Role of Prolactin as an Invasion Suppressor Hormone in Breast Cancer Cells

2006 • 114 citations

Differential Effects of Prolactin andsrc/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A

1999 • 113 citations

Caveolin-1-deficient Mice Show Accelerated Mammary Gland Development During Pregnancy, Premature Lactation, and Hyperactivation of the Jak-2/STAT5a Signaling Cascade

2002 • 110 citations

Loss of Stat5a delays mammary cancer progression in a mouse model

2002 • 110 citations

Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells

2006 • 108 citations

Prolactin as a Chemoattractant for Human Breast Carcinoma

1999 • 107 citations

Persistent Changes in Gene Expression Induced by Estrogen and Progesterone in the Rat Mammary Gland

2001 • 107 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

1995 • 105 citations

Caveolin-1 Mutations in Human Breast Cancer

2006 • 104 citations

Prolactin as a mitogen in mammary cells.

1997 • 104 citations

Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

1999 • 103 citations

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

2004 • 98 citations

Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer

2006 • 88 citations

Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

2004 • 83 citations

Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

2003 • 82 citations

Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6

2007 • 82 citations

Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions

2006 • 81 citations

Jak2 Is an Essential Tyrosine Kinase Involved in Pregnancy-Mediated Development of Mammary Secretory Epithelium

2002 • 80 citations

Loss of Caveolin-1 Causes the Hyper-Proliferation of Intestinal Crypt Stem Cells, with Increased Sensitivity to Whole Body ?-Radiation

2005 • 78 citations

Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis

2005 • 77 citations

The Janus Kinase 2 Is Required for Expression and Nuclear Accumulation of Cyclin D1 in Proliferating Mammary Epithelial Cells

2007 • 75 citations

Basal Activation of Transcription Factor Signal Transducer and Activator of Transcription (Stat5) in Nonpregnant Mouse and Human Breast Epithelium

2002 • 75 citations

Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b.

1998 • 74 citations

Caveolin-1 Deficiency (−/−) Conveys Premalignant Alterations in Mammary Epithelia, with Abnormal Lumen Formation, Growth Factor Independence, and Cell Invasiveness

2006 • 68 citations

Coactivation of Janus Tyrosine Kinase (Jak)1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Signal Transducer and Activator of Transcription (Stat)3 and Enhancement of Akt and Stat5a/b Pathways

2007 • 66 citations

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice

2006 • 65 citations

Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells

2003 • 64 citations

Promotion by prolactin of the growth of human breast neoplasms cultured in vitro in the soft agar clonogenic assay.

1986 • 58 citations

Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter

2005 • 55 citations

Stat5 in the mammary gland: Controlling normal development and cancer

2006 • 54 citations

Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK

2004 • 54 citations

Pregnancy and Stem Cell Behavior

2005 • 53 citations

Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context

2007 • 49 citations

Involvement of prolactin in breast cancer: redefining the molecular targets11Abbreviations: PRL, prolactin; PRLR, PRL receptor; GH, growth hormone; JAK, Janus kinase; STAT, signal transducer and activator of transcription; MAPK, Mitogen–activated protein kinase; PI 3-K, Phosphoinositide 3-kinase; FAK, focal–adhesion kinase; PKC, protein kinase C; SOCS, suppressor of cytokine signaling; PCD, programmed cell death.

2000 • 48 citations

STAT 5a expression in the breast is maintained in secretory carcinoma, in contrast to other histologic types

2006 • 41 citations

Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modeling.

2003 • 39 citations

In VivoResponse-Based Identification of Direct Hormone Target Cell Populations Using High-Density Tissue Arrays

2006 • 36 citations

Estrogen Negatively Regulates Epidermal Growth Factor (EGF)-Mediated Signal Transducer and Activator of Transcription 5 Signaling in Human EGF Family Receptor-Overexpressing Breast Cancer Cells

2005 • 36 citations

Using Gene Expression Arrays to Elucidate Transcriptional Profiles Underlying Prolactin Function

2003 • 34 citations

Persistent mammary hyperplasia in FVB/N mice.

2003 • 30 citations

Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling

2006 • 27 citations

Dominant‐negative Stat5 inhibits growth and induces apoptosis in T47D‐derived tumors in nude mice

2004 • 27 citations

Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer.

2005 • 26 citations

STAT 5a expression in various lesions of the breast

2005 • 24 citations

Modulation of Signal Transducer and Activator of Transcription 5b Activity in Breast Cancer Cells by Mutation of Tyrosines within the Transactivation Domain

2006 • 24 citations

Tumors caused by overexpression and forced activation of Stat5 in mammary epithelial cells of transgenic mice are parity‐dependent and developed in aged, postestropausal females

2007 • 20 citations

Project acceleration — the case for quantum change

1997 • 20 citations

The role of stat5 in estrogen receptor-positive breast cancer

2002 • 17 citations

Models of breast cancer

2005 • 14 citations