Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

1998 • 484 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Estrogen receptors α and β in the rodent mammary gland

2000 • 357 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

1999 • 283 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

1997 • 248 citations

A comparison of transcriptional activation by ERα and ERβ

1999 • 239 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation

1999 • 231 citations

Thrombopoietin-Induced Differentiation of a Human Megakaryoblastic Leukemia Cell Line, CMK, Involves Transcriptional Activation of p21^WAF1/Cip1 by STAT5

1997 • 189 citations

Prolactin Signaling in Mammary Gland Development

1997 • 174 citations

Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580

1996 • 171 citations

Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells

1998 • 143 citations

Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family

1999 • 120 citations

Regulation of mammary gland factor/Stat5a during mammary gland development.

1995 • 119 citations

Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells

2002 • 109 citations

Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor

1998 • 96 citations

Stat transcription factors in mammary gland development and tumorigenesis.

2001 • 90 citations

Prolactin Stimulates Serine/Tyrosine Phosphorylation and Formation of Heterocomplexes of Multiple Stat5 Isoforms in Nb2 Lymphocytes

1997 • 86 citations

Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression

2001 • 80 citations

Cross-Talk Between ERs and Signal Transducer and Activator of Transcription 5 Is E2 Dependent and Involves Two Functionally Separate Mechanisms

2001 • 80 citations

Stat5a Serine Phosphorylation

2000 • 79 citations

Serine Phosphorylation of GH-Activated Signal Transducer and Activator of Transcription 5a (STAT5a) and STAT5b: Impact on STAT5 Transcriptional Activity

2001 • 68 citations

Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line

2000 • 65 citations

Two Discrete Regions of Interleukin-2 (IL2) Receptor β Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase

1997 • 62 citations

Expression Level-Dependent Contribution of Glucocorticoid Receptor Domains for Functional Interaction with STAT5

2001 • 51 citations

Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells

2001 • 49 citations

Differential Roles for Signal Transducers and Activators of Transcription 5a and 5b in PRL Stimulation of ERα and ERβ Transcription

2001 • 46 citations

EGF Modulates Expression of STAT5 in Mammary Epithelial Cells

1998 • 35 citations

Activation of STAT5 during EPO-directed suppression of apoptosis

2000 • 35 citations

Cross-Talk between Signal Transducer and Activator of Transcription (Stat5) and Thyroid Hormone Receptor-β 1 (TRβ1) Signaling Pathways

2000 • 27 citations

Carboxyl-Truncated STAT5β Is Generated by a Nucleus-Associated Serine Protease in Early Hematopoietic Progenitors

1998 • 10 citations