Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer

Stat3 as an Oncogene

1999 • 2,770 citations

The STATs of cancer — new molecular targets come of age

2004 • 2,232 citations

Prognostic and predictive factors in breast cancer by immunohistochemical analysis.

1998 • 2,121 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Cross-Talk between Estrogen Receptor and Growth Factor Pathways as a Molecular Target for Overcoming Endocrine Resistance

2004 • 453 citations

Crosstalk between Estrogen Receptor and Growth Factor Receptor Pathways as a Cause for Endocrine Therapy Resistance in Breast Cancer

2005 • 444 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Signal Transducer and Activator of Transcription-5 Activation and Breast Cancer Prognosis

2004 • 221 citations

Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.

2003 • 194 citations

Roles and Regulation of Stat Family Transcription Factors in Human Breast Cancer

2004 • 192 citations

Prolactin Signaling in Mammary Gland Development

1997 • 174 citations

Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

2003 • 155 citations

Signal Transducers and Activators of Transcription as Downstream Targets of Nongenomic Estrogen Receptor Actions

2002 • 143 citations

Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers

2003 • 136 citations

Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family

1999 • 120 citations

EGFR dependent expression of STAT3 (but not STAT1) in breast cancer

2001 • 120 citations

Stat transcription factors in mammary gland development and tumorigenesis.

2001 • 90 citations

Cross‐talk between signal transducer and activator of transcription 3 and estrogen receptor signaling

2000 • 88 citations

Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

2003 • 82 citations

Cross-Talk Between ERs and Signal Transducer and Activator of Transcription 5 Is E2 Dependent and Involves Two Functionally Separate Mechanisms

2001 • 80 citations

Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression

2001 • 80 citations

Basal Activation of Transcription Factor Signal Transducer and Activator of Transcription (Stat5) in Nonpregnant Mouse and Human Breast Epithelium

2002 • 75 citations

Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells

2001 • 49 citations

Differential Roles for Signal Transducers and Activators of Transcription 5a and 5b in PRL Stimulation of ERα and ERβ Transcription

2001 • 46 citations

Mutations in the Estrogen Receptor DNA-binding Domain Discriminate between the Classical Mechanism of Action and Cross-talk with Stat5b and Activating Protein 1 (AP-1)

2002 • 45 citations

ERα and STAT5a cross‐talk: interaction through C‐terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA‐binding

2004 • 41 citations

Dominant‐negative Stat5 inhibits growth and induces apoptosis in T47D‐derived tumors in nude mice

2004 • 27 citations

Cross-Talk Between ERs and Signal Transducer and Activator of Transcription 5 Is E2 Dependent and Involves Two Functionally Separate Mechanisms

2001 • 24 citations

The role of stat5 in estrogen receptor-positive breast cancer

2002 • 17 citations

Differential roles for signal transducers and activators of transcription 5a and 5b in PRL stimulation of ERalpha and ERbeta transcription

2001 • 14 citations

Basal Activation of Transcription Factor Signal Transducer and Activator of Transcription (Stat5) in Nonpregnant Mouse and Human Breast Epithelium

2002 • 11 citations