The Genes Induced by Signal Transducer and Activators of Transcription (STAT)3 and STAT5 in Mammary Epithelial Cells Define the Roles of these STATs in Mammary Development

STATs: transcriptional control and biological impact

2002 • 3,050 citations

AP-1: a double-edged sword in tumorigenesis

2003 • 2,077 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

New insights into TGF-β–Smad signalling

2004 • 1,169 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

T<scp>he</scp>R<scp>ole of</scp>S<scp>uppressors of</scp>C<scp>ytokine</scp>S<scp>ignaling</scp>(SOCS) P<scp>roteins in</scp>R<scp>egulation of the</scp>I<scp>mmune</scp>R<scp>esponse</scp>

2004 • 696 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

2004 • 491 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1998 • 442 citations

Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression

2003 • 328 citations

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

1995 • 232 citations

Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.

2003 • 194 citations

A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

2003 • 192 citations

Antiapoptotic activity ofStat5required during terminal stages of myeloid differentiation

2000 • 188 citations

Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice

2001 • 165 citations

Control of myeloid differentiation and survival by Stats

2000 • 136 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

2003 • 122 citations

EGFR dependent expression of STAT3 (but not STAT1) in breast cancer

2001 • 120 citations

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.

2002 • 117 citations

NF-κB Inhibits Apoptosis in Murine Mammary Epithelia

2000 • 112 citations

Loss of Stat5a delays mammary cancer progression in a mouse model

2002 • 110 citations

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

2005 • 109 citations

Differential activation of STATs 3 and 5 during mammary gland development

1996 • 108 citations

Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

1999 • 103 citations

Role for the Adaptor Protein Grb10 in the Activation of Akt

2002 • 98 citations

C/EBPδ is a crucial regulator of pro-apoptotic gene expression during mammary gland involution

2005 • 97 citations

Transcriptional Changes Underlying the Secretory Activation Phase of Mammary Gland Development

2005 • 95 citations

Signal Transducer and Activator of Transcription 3 Activates CCAAT Enhancer-binding Protein δ Gene Transcription in G0Growth-arrested Mouse Mammary Epithelial Cells and in Involuting Mouse Mammary Gland

2000 • 76 citations

Microarray Analysis of the Involution Switch

2003 • 70 citations

Insulin Induction of SOCS-2 and SOCS-3 mRNA Expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*

2001 • 69 citations

NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the α-Helical Region of the STAT5 Transactivation Domain

2003 • 68 citations

Interleukin-9 Regulates NF-κB Activity Through BCL3 Gene Induction

1999 • 66 citations

Differential Interactions of Specific Nuclear Factor I Isoforms with the Glucocorticoid Receptor and STAT5 in the Cooperative Regulation of WAP Gene Transcription

2001 • 64 citations

Transcription factor activities and gene expression during mouse mammary gland involution.

1999 • 62 citations

Tissue-Specific Induction of SOCS Gene Expression by PRL

2001 • 62 citations

A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland

2000 • 46 citations

TEL/ETV6 Is a Signal Transducer and Activator of Transcription 3 (Stat3)-induced Repressor of Stat3 Activity

2004 • 32 citations

Secretion of prosaposin, a multifunctional protein, by breast cancer cells

1999 • 29 citations

An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland of pregnant mice but is dispensable during lactation.

1995 • 27 citations

Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer.

2005 • 26 citations