Uptake and processing of Chlamydia trachomatis by human dendritic cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis

1998 • 1,548 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Interaction of chlamydiae and host cells in vitro

1991 • 734 citations

Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells

1999 • 564 citations

Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane.

1996 • 387 citations

Interaction of chlamydiae and host cells in vitro.

1991 • 327 citations

Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes.

1988 • 323 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells

1998 • 262 citations

Mechanism of C. trachomatis attachment to eukaryotic host cells

1992 • 244 citations

Immunity to MurineChlamydia trachomatisGenital Tract Reinfection Involves B Cells and CD4⁺T Cells but Not CD8⁺T Cells

2000 • 241 citations

Coordinated events during bacteria-induced DC maturation

1999 • 219 citations

Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid

1997 • 198 citations

IL-10 Gene Knockout Mice Show Enhanced Th1-Like Protective Immunity and Absent Granuloma Formation FollowingChlamydia trachomatisLung Infection

1999 • 189 citations

Vesicular interactions of the Chlamydia trachomatis inclusion are determined by chlamydial early protein synthesis rather than route of entry

1996 • 176 citations

The Epidemiology of Chlamydia trachomatis within a Sexually Transmitted Diseases Core Group

1996 • 151 citations

Langerhans cells, macrophages and lymphocyte subsets in the cervix and vagina of rhesus macaques.

1992 • 144 citations

A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis

1990 • 113 citations

Langerhans Cells and T Lymphocyte Subsets in the Murine Vagina and Cervix1

1991 • 106 citations

Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens.

1991 • 102 citations

Interleukin-12 Production Is Required for Chlamydial Antigen-Pulsed Dendritic Cells To Induce Protection against Live Chlamydia trachomatis Infection

1999 • 91 citations

Direct Detection and Magnetic Isolation ofChlamydia trachomatisMajor Outer Membrane Protein-Specific CD8+ CTLs with HLA Class I Tetramers

2000 • 73 citations

Infectivity ofChlamydia trachomatisSerovar LGV but Not E Is Dependent on Host Cell Heparan Sulfate

2001 • 73 citations

Chlamydia trachomatis major outer membrane protein (MOMP) epitopes that activate HLA class II-restricted T cells from infected humans.

1996 • 73 citations

Vesicles containing Chlamydia trachomatis serovar L2 remain above pH 6 within HEC-1B cells

1996 • 70 citations

Identification of Chlamydia trachomatis antigens recognized by human CD4+ T lymphocytes by screening an expression library

2001 • 62 citations

Epidemiology of Ocular Chlamydial Infection in a Trachoma-Hyperendemic Area

1991 • 58 citations

Processing of bacterial antigens for peptide presentation on MHC class I molecules

1999 • 51 citations

Identification and characterization of a DR4-restricted T cell epitope within chlamydia heat shock protein 60

1997 • 48 citations

Update on Chlamydia trachomatis

2000 • 47 citations

Role of annexins in endocytosis of antigens in immature human dendritic cells

1997 • 43 citations

Synthetic peptides based on Chlamydia trachomatis antigens identify cytotoxic T lymphocyte responses in subjects from a trachoma-endemic population

1997 • 34 citations

Epidemiologic, clinical, and therapeutic aspects of reactive arthritis and ankylosing spondylitis

1995 • 25 citations

Chlamydia-associated reactive arthritis.

2000 • 19 citations

Interleukin-12 Production Is Required for Chlamydial Antigen-Pulsed Dendritic Cells To Induce Protection against Live Chlamydia trachomatis Infection

1999 • 12 citations

Isolation and characterisation of T lymphocytes from the urethra of patients with acute urethritis.

1998 • 8 citations

Failure to detect HLA-A*6802-restricted CD8+ T cells specific forChlamydia trachomatisantigens in subjects from trachoma-endemic communities

2001 • 6 citations