Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

1994 • 1,199 citations

Essentials of medical statistics.

1988 • 934 citations

Single base polymorphism in the human Tumour Necrosis Factor alpha (TNFα) gene detectable by Ncol restriction of PCR product

1992 • 903 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF‐a and TNF‐0 by human mononuclear cells: a possible link to insulin‐dependent diabetes mellitus

1993 • 562 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

1995 • 459 citations

A polymorphic variation in a putative regulation box of the TNFA promoter region

1994 • 362 citations

Importance of Reinfection in the Pathogenesis of Trachoma

1985 • 274 citations

Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes.

1988 • 227 citations

EPIDEMIOLOGY OF ECTOPIC PREGNANCY

1987 • 201 citations

The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated

1995 • 197 citations

The Association Between Chlamydia trachomatis and Ectopic Pregnancy

1990 • 190 citations

Tumour necrosis factor-alpha (TNF-α) gene polymorphism and expression in pre-eclampsia

1996 • 158 citations

Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha

1993 • 151 citations

Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD)

1996 • 151 citations

Pathogenesis of trachoma: the stimulus for inflammation.

1987 • 143 citations

Conjunctival Scarring in Trachoma Is Associated with Depressed Cell-Mediated Immune Responses to Chlamydial Antigens

1993 • 139 citations

A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis

1990 • 113 citations

Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor

1988 • 108 citations

Regulation of human lung fibroblast glycosaminoglycan production by recombinant interferons, tumor necrosis factor, and lymphotoxin.

1988 • 97 citations

Subjects recovering from human ocular chlamydial infection have enhanced lymphoproliferative responses to chlamydial antigens compared with those of persistently diseased controls

1995 • 85 citations

HLA Class I and II Polymorphisms and Trachomatous Scarring in a Chlamydia trachomatis-Endemic Population

1996 • 74 citations

Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma

1996 • 65 citations

The Natural History of Endemic Trachoma: a Longitudinal Study

1992 • 61 citations

Polymerase Chain Reaction For The Detection Of Ocular Chlamydial Infection In Trachoma-Endemic Communities

1994 • 61 citations

Reversion of the antichlamydial effect of tumor necrosis factor by tryptophan and antibodies to beta interferon

1989 • 58 citations

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

1989 • 44 citations

Tumor necrosis factor alpha activity in genital tract secretions of guinea pigs infected with chlamydiae

1995 • 37 citations

Modulation of the transcripts for tumor necrosis factor‐α and its receptors in vivo

1994 • 14 citations

Effects of a Tumour Necrosis Factor (TNFα) Promoter Base Transition on Trancriptional Activity

1994 • 2 citations