Interleukin-12 Production Is Required for Chlamydial Antigen-Pulsed Dendritic Cells To Induce Protection against Live Chlamydia trachomatis Infection

Dendritic cells and the control of immunity

1998 • 14,345 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Phagocytosis of antigens by Langerhans cells in vitro.

1993 • 474 citations

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

1997 • 432 citations

Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways.

1997 • 365 citations

New Knowledge of Chlamydiae and the Diseases They Cause

1975 • 364 citations

Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection

1995 • 333 citations

Chlamydial Infections

1978 • 270 citations

CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract

1995 • 263 citations

Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice

1997 • 254 citations

IL-12: a key cytokine in immune regulation

1996 • 236 citations

Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection.

1996 • 212 citations

Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response

1997 • 204 citations

Vaccination against Chlamydial Genital Tract Infection after Immunization with Dendritic Cells Pulsed Ex Vivo with Nonviable Chlamydiae

1998 • 194 citations

Dendritic Cells Efficiently Induce Protective Antiviral Immunity

1998 • 189 citations

Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.

1993 • 166 citations

Dendritic Cells as Carriers for a Cytotoxic T-Lymphocyte Epitope-Based Peptide Vaccine in Protection Against a Human Papillomavirus Type 16-Induced Tumor

1995 • 131 citations

Internalization of Chlamydia by Dendritic Cells and Stimulation of Chlamydia-Specific T Cells

1998 • 113 citations

Protective monoclonal antibodies to Chlamydia trachomatis serovar- and serogroup-specific major outer membrane protein determinants

1989 • 108 citations

DNA Vaccination with the Major Outer‐Membrane Protein Gene Induces Acquired Immunity toChlamydia trachomatis(Mouse Pneumonitis) Infection

1997 • 108 citations

Conformational mimicry of a chlamydial neutralization epitope on filamentous phage.

1994 • 90 citations

Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chlamydia trachomatis.

1993 • 77 citations

Immunogenicity of a chimeric peptide corresponding to T helper and B cell epitopes of the Chlamydia trachomatis major outer membrane protein.

1992 • 67 citations

Th1 cells specific for a secreted protein of Listeria monocytogenes are protective in vivo.

1998 • 60 citations

Role of endogenous gamma interferon in host defense against Chlamydia trachomatis infections

1989 • 58 citations

Th1 Cells Specific for a Secreted Protein ofListeria monocytogenesAre Protective In Vivo

1998 • 51 citations

Mapping antigenic sites on the major outer membrane protein of Chlamydia trachomatis with synthetic peptides

1990 • 49 citations

Recombinant murine gamma interferon inhibits Chlamydia trachomatis serovar L1 in vivo

1988 • 46 citations

Antigen Conformation Dependence ofChlamydia trachomatisInfectivity Neutralization

1997 • 22 citations

Mapping epitopes of neutralizing monoclonal antibodies using phage random peptide libraries

1997 • 8 citations