Precise Registration of Gene Expression Boundaries by a Repressive Morphogen in Drosophila

The chemical basis of morphogenesis

1952 • 11,233 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome

2002 • 619 citations

Dynamic control of positional information in the early Drosophila embryo

2004 • 577 citations

Forging patterns and making waves from biology to geology: a commentary on Turing (1952) ‘The chemical basis of morphogenesis’

2015 • 566 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

Regulation of even-skipped stripe 2 in the Drosophila embryo.

1992 • 522 citations

Stability and Nuclear Dynamics of the Bicoid Morphogen Gradient

2007 • 510 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid

1986 • 386 citations

Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

1987 • 370 citations

Multiplex Detection of RNA Expression in Drosophila Embryos

2004 • 367 citations

Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres

1988 • 366 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Regulation of a Segmentation Stripe by Overlapping Activators and Repressors in the Drosophila Embryo

1991 • 321 citations

The Drosophila posterior-group gene nanos functions by repressing hunchback activity

1989 • 301 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo

1987 • 289 citations

Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins

1998 • 266 citations

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo

1990 • 258 citations

Transcriptional Control in the Segmentation Gene Network of Drosophila

2004 • 254 citations

Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients*

1999 • 243 citations

Regulation of Two Pair-Rule Stripes by a Single Enhancer in theDrosophilaEmbryo

1996 • 243 citations

Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila

1994 • 232 citations

Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos

1989 • 222 citations

Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura.

2004 • 217 citations

A self-organizing system of repressor gradients establishes segmental complexity in Drosophila

2003 • 213 citations

Activation of posterior gap gene expression in the Drosophila blastoderm

1995 • 201 citations

Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene

1989 • 198 citations

A gap gene, hunchback, regulates the spatial expression of Ultrabithorax

1986 • 195 citations

The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila

2005 • 177 citations

Computational Models for Neurogenic Gene Expression in the Drosophila Embryo

2006 • 170 citations

Homotypic Regulatory Clusters in Drosophila

2003 • 168 citations

Mutually repressive interactions between the gap genes giant and Krüppel define middle body regions of the Drosophila embryo

1991 • 159 citations

Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes

1991 • 152 citations

Differential regulation of the two transcripts from the Drosophila gap segmentation gene hunchback.

1988 • 149 citations

Specifying Positional Information in the Embryo: Looking Beyond Morphogens

2007 • 146 citations

Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element

1995 • 138 citations

Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the drosophila embryo

1990 • 137 citations

Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline.

2006 • 136 citations

cis-acting control elements for Krüppel expression in the Drosophila embryo.

1990 • 120 citations

The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes

1992 • 112 citations

Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens bicoid and hunchback.

1991 • 110 citations

Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein.

1992 • 95 citations

Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo

1994 • 87 citations

Permissive and Instructive Anterior Patterning Rely on mRNA Localization in the Wasp Embryo

2007 • 85 citations

Anterior repression of aDrosophilastripe enhancer requires three position-specific mechanisms

2002 • 84 citations

Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant

1998 • 68 citations

Thoracic Patterning by the Drosophila Gap Gene hunchback

2001 • 62 citations

Groucho-dependent repression by Sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo

2004 • 52 citations

Regulatory and coding regions of the segmentation gene hunchback are functionally conserved between Drosophila virilis and Drosophila melanogaster

1994 • 51 citations

Positioning adjacent pair-rule stripes in the posterior Drosophila embryo

1994 • 46 citations

[10] In Vivo analysis of lacZ fusion genes in transgenic Drosophila melanogaster

2000 • 24 citations

Regulation of expression domains and effects of ectopic expression reveal gap gene-like properties of the linked pdm genes of Drosophila

1993 • 23 citations